PUBLICATION
Flies and fish: birds of a feather
- Authors
- Tamai, T.K., Vardhanabhuti, V., Arthur, S., Foulkes, N.S., and Whitmore, D.
- ID
- ZDB-PUB-030312-14
- Date
- 2003
- Source
- Journal of neuroendocrinology 15(4): 344-349 (Journal)
- Registered Authors
- Foulkes, Nicholas-Simon, Tamai, Takako Katherine, Whitmore, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Biological Clocks/genetics*
- Biological Clocks/radiation effects
- CLOCK Proteins
- Cell Line/physiology
- Cell Line/radiation effects
- Cells, Cultured/physiology
- Cells, Cultured/radiation effects
- Circadian Rhythm/genetics*
- Circadian Rhythm/radiation effects
- Drosophila/physiology*
- Gene Expression Regulation/physiology*
- Gene Expression Regulation/radiation effects
- Light*
- Liver/physiology
- Mammals/physiology
- Mice
- Photoperiod
- Rats
- Species Specificity
- Suprachiasmatic Nucleus/physiology
- Tissue Distribution/genetics
- Trans-Activators/genetics
- Zebrafish/physiology*
- PubMed
- 12622832 Full text @ J. Neuroendocrinol.
Citation
Tamai, T.K., Vardhanabhuti, V., Arthur, S., Foulkes, N.S., and Whitmore, D. (2003) Flies and fish: birds of a feather. Journal of neuroendocrinology. 15(4):344-349.
Abstract
The identification of specific clock-containing structures has been a major endeavour of the circadian field for many years. This has lead to the identification of many key components of the circadian system, including the suprachiasmatic nucleus in mammals, and the eyes and pineal glands in lower vertebrates. However, the idea that these structures represent the only clocks in animals has been challenged by the discovery of peripheral pacemakers in most organs and tissues, and even a number of cell lines. In Drosophila, and vertebrates such as the zebrafish, these peripheral clocks appear to be highly autonomous, being set directly by the environmental light/dark cycle. However, a hierarchy of clocks may still exist in mammals. In this review, we examine some of the current views regarding peripheral clocks, their organization and how they are entrained.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping