|ZFIN ID: ZDB-PUB-030211-11|
Membrane properties related to the firing behavior of zebrafish motoneurons
Buss, R.R., Bourque, C.W., and Drapeau, P.
|Source:||Journal of neurophysiology 89(2): 657-664 (Journal)|
|Registered Authors:||Buss, Robert, Drapeau, Pierre|
|PubMed:||12574443 Full text @ J. Neurophysiol.|
Buss, R.R., Bourque, C.W., and Drapeau, P. (2003) Membrane properties related to the firing behavior of zebrafish motoneurons. Journal of neurophysiology. 89(2):657-664.
ABSTRACTThe physiological and pharmacological properties of the motoneuron membrane and action potential were investigated in larval zebrafish using whole cell patch current-clamp recording techniques. Action potentials were eliminated in tetrodotoxin, repolarized by tetraethylammonium (TEA) and 3,4-diaminopyridine (3,4-AP)-sensitive potassium conductances, and had a cobalt-sensitive, high-threshold calcium component. Depolarizing current injection evoked a brief (approximately 10-30 ms) burst of action potentials that was terminated by strong, outwardly rectifying voltage-activated potassium and calcium-dependent conductances. In the presence of intracellular cesium ions, a prolonged plateau potential often followed brief depolarizations. During larval development (hatching to free-swimming), the resting membrane conductance increased in a population of motoneurons, which tended to reduce the apparent outward rectification of the membrane. The conductances contributing to action potential burst termination are hypothesized to play a role in patterning the synaptically driven motoneuron output in these rapidly swimming fish.
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