|ZFIN ID: ZDB-PUB-030106-6|
Partial sequence of a transferrin homolog from Danio rerio (zebrafish)
Moczydlowski, E., Berliner, N., Benz, E.J. Jr., Zon, L., Blakaj, D., Barnes, B., Ruck, B., and Leach, T.M.
|Source:||Bull. Mt. Desert Isl. Biol. Lab. 38: 3-4 (Other)|
|Registered Authors:||Moczydlowski, Edward, Zon, Leonard I.|
|Keywords:||Proteins; Blood; Iron; Disease resistance; Danio rerio, transferrins; Zebra danio|
Moczydlowski, E., Berliner, N., Benz, E.J. Jr., Zon, L., Blakaj, D., Barnes, B., Ruck, B., and Leach, T.M. (1999) Partial sequence of a transferrin homolog from Danio rerio (zebrafish). Bull. Mt. Desert Isl. Biol. Lab.. 38:3-4.
ABSTRACTTransferrin (Tf) is a vertebrate plasma protein that binds two Fe super(3+) ions in a bicarbonate dependent fashion. Tf functions in the transport and delivery of iron to cells via transferrin receptor-mediated endocytosis. As iron is required for the growth of many bacteria and free Fe super(3+)/Fe super(2+) is involved in the generation of chemically damaging hydroxyl free radicals, Tf also functions to limit bacterial infections and protect against iron toxicity. Lactoferrin (Lf) is an Fe super(3+)-binding homolog of Tf present in milk and secretions that bathe mucosal surfaces. Lf is also secreted by neutrophils and is believed to play a role in modulation of immune and inflammatory responses.
- Genes / Markers (1)