PUBLICATION

Cell proliferation curves of different human tumor lines after in vitro treatment with zebrafish embryonic extracts

Authors
Biava, P.M., Bonsignorio, D., and Hoxha, M.
ID
ZDB-PUB-021017-40
Date
2001
Source
J. Tumor Mark. Oncol.   16(3): 195-202 (Journal)
Registered Authors
Bonsignorio, Daniele
Keywords
none
MeSH Terms
none
PubMed
none
Abstract
Five tumor cell lines of different origin (glioblastoma, melanoma, kidney adenocarcinoma, breast carcinoma and lymphoblastic leukemia) were treated in vitro with the extracts from zebrafish embryos collected at four different developmental stages. All cell lines responded with a significant slowing of the proliferation when treated with the extracts taken during the stages of cell differentiation, while no slowing effect was observed when they were treated with the extract taken from a merely multiplicative stage. These results suggest that a complex network of molecular factors during embryo differentiation may help abnormally proliferating cells to normalize their cycle, and that the administration of embryonic cell differentiation factors may be a useful tool in cancer therapy. On the other hand, it is known that the stem cells can be differentiated into different types of cells in relationship to different kinds of embryonic microenvironment. Since this network of cell differentiation factors may normalize the altered expression of genes, we suggest it as a sort of physiological gene therapy.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping