PUBLICATION
The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII
- Authors
- de Caestecker, M.P., Bottomley, M., Bhattacharyya, S., Payne, T.L., Roberts, A.B., and Yelick, P.C.
- ID
- ZDB-PUB-020618-9
- Date
- 2002
- Source
- Biochemical and Biophysical Research Communications 293(5): 1556-1565 (Journal)
- Registered Authors
- Payne-Ferreira, Tracie
- Keywords
- none
- MeSH Terms
-
- Activin Receptors, Type I*
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Blotting, Western
- Bone Morphogenetic Proteins/metabolism
- Cell Line
- Cross-Linking Reagents/pharmacology
- Humans
- In Situ Hybridization
- Ligands
- Luciferases/metabolism
- Mice
- Molecular Sequence Data
- Mutation
- Precipitin Tests
- Protein Binding
- Protein Serine-Threonine Kinases*
- Protein Structure, Tertiary
- Receptors, Transforming Growth Factor beta/chemistry*
- Receptors, Transforming Growth Factor beta/metabolism*
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Tissue Distribution
- Transforming Growth Factor beta/metabolism*
- Zebrafish
- Zebrafish Proteins/chemistry*
- Zebrafish Proteins/metabolism*
- PubMed
- 12054694 Full text @ Biochem. Biophys. Res. Commun.
Citation
de Caestecker, M.P., Bottomley, M., Bhattacharyya, S., Payne, T.L., Roberts, A.B., and Yelick, P.C. (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochemical and Biophysical Research Communications. 293(5):1556-1565.
Abstract
The TGF-beta superfamily consists of an array of ligands including BMP, TGF-beta, activin, and nodal subfamilies. The extensive range of biological effects elicited by TGF-beta family signaling is due in part to the large numbers and promiscuity of types I and II TGF-beta family member receptors. Alk8 is a novel type I TGF-beta family member receptor first identified in zebrafish [Dev. Dyn. 211 (4) (1998) 352], which participates in BMP signaling pathways [Development 128 (6) (2001) 849; Development 128 (6) (2001) 859; Mech. Dev. 100 (2) (2001) 275; J. Dent. Res. 80 (11) (2001) 1968]. Here we report that Alk8 also forms active signaling complexes with TGF-beta in the presence of TGF-betaRII. These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping