Ishimaru, Y., Yoshioka, H., Tao, H., Thisse, B., Thisse, C., Wright, C.V.E., Hamada, H. Ohuchi, H., and Noji, S. (2000) Asymmetric expression of antivin/lefty1 in the early chick embryo. Mechanisms of Development. 90(1):115-118.
Mammalian lefty and zebrafish antivin, highly related to lefty, are shown to be expressed asymmetrically and involved in the specification of the left body side of early embryos. We isolated a chick homologue of the antivin/lefty1 cDNA and studied its expression pattern during early chick development. We found that antivin/lefty1 is expressed asymmetrically on the left side of the prospective floorplate, notochord and lateral plate mesoderm of the chick embryo.