PUBLICATION
The zebrafish as a model system for human disease
- Authors
- Ward, A.C. and Lieschke, G.J.
- ID
- ZDB-PUB-020402-3
- Date
- 2002
- Source
- Frontiers in bioscience : a journal and virtual library 7: 7-833 (Review)
- Registered Authors
- Ward, Alister
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Environmental Exposure
- Genetic Diseases, Inborn/genetics
- Heart Diseases/etiology
- Hematologic Diseases/etiology
- Humans
- Kidney Diseases/etiology
- Mutation
- Zebrafish/genetics*
- PubMed
- 11897571 Full text @ Front. Biosci.
Citation
Ward, A.C. and Lieschke, G.J. (2002) The zebrafish as a model system for human disease. Frontiers in bioscience : a journal and virtual library. 7:7-833.
Abstract
The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. This review aims to describe several representative examples of how the zebrafish can be successfully used to identify novel genes and assign gene function, providing invaluable clues to human pathophysiology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping