|ZFIN ID: ZDB-PUB-020227-3|
The evolution of morphological complexity in zebrafish stripes
Mellgren, E.M. and Johnson, S.L.
|Source:||Trends in genetics : TIG 18(3): 128-134 (Review)|
|Registered Authors:||Johnson, Stephen L., Mellgren, Eve M.|
|PubMed:||11858836 Full text @ Trends Genet.|
Mellgren, E.M. and Johnson, S.L. (2002) The evolution of morphological complexity in zebrafish stripes. Trends in genetics : TIG. 18(3):128-134.
ABSTRACTThe zebrafish pigment stripe pattern is a complex tissue containing iridophores, xanthophores and multiple melanocyte types. Mutational analysis reveals that both ancient and recent gene duplications are involved in the generation or maintenance of the pattern complexity. Receptor tyrosine kinases kit and fms, products of an ancient gene duplication, are required in distinct types of melanocytes and xanthophores. Transcription factors mitfa and mitfb, results of a teleost-specific duplication, partition gene expression and function between different sets of melanocytes. Understanding the roles of these duplicated genes in zebrafish allows us to predict roles for their precursors in ancestral vertebrates.