ZFIN ID: ZDB-PUB-011217-7
Expression of zTlxA, a Hox11-like gene, in early differentiating embryonic neurons and cranial sensory ganglia of the zebrafish embryo
Andermann, P. and Weinberg, E.S.
Date: 2001
Source: Developmental dynamics : an official publication of the American Association of Anatomists   222(4): 595-610 (Journal)
Registered Authors: Andermann, Peter, Weinberg, Eric
Keywords: Tlx-1, Tlx-3, Hox11, homeodomain, trigeminal, statoacoustic, vagal, lateral line, Rohon-Beard cells, semicircular canals, messenger RNA expression, T cell oncogene, homeobox gene, motor neurons, developmental expression, Brachydanio rerio, chick embryo, hindbrain, homolog, protein
MeSH Terms:
  • Amino Acid Sequence/genetics
  • Animals
  • Cell Differentiation
  • Central Nervous System/cytology
  • Central Nervous System/embryology
  • Embryo, Nonmammalian/physiology
  • Ganglia, Sensory/embryology*
  • Gene Expression*
  • Homeodomain Proteins/genetics*
  • Homeodomain Proteins/isolation & purification
  • Molecular Sequence Data
  • Neurons/cytology
  • Neurons/physiology*
  • Oncogene Proteins/genetics
  • Time Factors
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/isolation & purification
PubMed: 11748829 Full text @ Dev. Dyn.
We have isolated a cDNA encoding a member of the Tlx/Hox11 family of homeodomain factors from the zebrafish, most closely related to the vertebrate Tlx-1/Hox11 and Tlx-3/Hox11L2 proteins. The gene is expressed in a set of early differentiating neurons that project to a common tract, the lateral longitudinal fascicle. We show that the gene is specifically expressed in spinal cord Rohon Beard neurons, in nucleus of the posterior commissure neurons of the midbrain, in a set of hindbrain neurons that include RoL3 reticulospinal interneurons, and in the trigeminal, statoacoustic, anterior lateral line, glossopharyngeal, and vagal cranial sensory ganglia. Timing of expression of the gene in these neurons correlates with the phase of axonal outgrowth and target innervation. Expression of the gene is also observed in several non-neural tissues, including the pharyngeal arches, budding gill filaments, outgrowing semicircular protrusions in the otic vesicle, and in the pectoral fin buds.