PUBLICATION
frizzled 9 is expressed in neural precursor cells in the developing neural tube
- Authors
- Van Raay, T.J., Wang, Y.K., Stark, M.R., Rasmussen, J.T., Francke, U., Vetter, M.L., and Rao, M.S.
- ID
- ZDB-PUB-011109-8
- Date
- 2001
- Source
- Development genes and evolution 211(8-9): 453-457 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Molecular Sequence Data
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Blotting, Western
- Gene Expression Regulation, Developmental
- Phylogeny
- Organ Specificity
- Conserved Sequence
- Sequence Homology, Amino Acid
- Mice
- In Situ Hybridization
- Central Nervous System/cytology*
- Central Nervous System/embryology*
- Animals
- Humans
- Zebrafish/embryology
- Zebrafish/genetics
- Receptors, Neurotransmitter/genetics*
- Receptors, Neurotransmitter/metabolism*
- Stem Cells/metabolism*
- Zebrafish Proteins
- Chick Embryo
- Cloning, Molecular
- PubMed
- 11685582 Full text @ Dev. Genes Evol.
Citation
Van Raay, T.J., Wang, Y.K., Stark, M.R., Rasmussen, J.T., Francke, U., Vetter, M.L., and Rao, M.S. (2001) frizzled 9 is expressed in neural precursor cells in the developing neural tube. Development genes and evolution. 211(8-9):453-457.
Abstract
The wnt signaling pathway has important functions in nervous system development. To better understand this process we have cloned and analyzed the expression of the wnt receptor, frizzled 9, in the developing nervous system in mouse, chick and zebrafish. The earliest expression of mouse frizzled 9 mRNA expression begins at E8.5 with expression throughout the entire rostral-caudal neuraxis. This early expression pattern within the neural tube appears to be conserved between chick and zebrafish. Expression becomes restricted to a ventral domain in the mouse ventricular zone at E11.5, a region specified to give rise to neurons and glia. Using a polyclonal antibody to MFZ9 further shows expression limited to neural restricted precursors cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping