ZFIN ID: ZDB-PUB-010919-1
Zebrafish myelopoiesis and blood cell development
Hsu, K., Kanki, J.P., and Look, A.T.
Date: 2001
Source: Current opinion in hematology   8(4): 245-251 (Review)
Registered Authors: Hsu, Karl, Kanki, John, Look, A. Thomas
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Antisense Elements (Genetics)
  • Gene Expression Regulation, Developmental
  • Hematologic Diseases/etiology
  • Hematopoiesis*
  • Mutagenesis, Insertional
  • Mutation
  • Myeloid Progenitor Cells/physiology*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed: 11561163 Full text @ Curr. Opin. Hematol.
The zebrafish (Danio rerio) animal model offers a unique opportunity to discover novel genes required for the control of normal vertebrate myeloid cell development. It is well suited for both developmental and genetic analyses: eg, genome-wide chemical mutagenesis screens have led to the identification of specific new genes affecting vertebrate erythropoiesis. Mutants defective in one or more hematopoietic functions will be useful as models of human disease and will assist in the elucidation of lineage-specific developmental programs. By using a combination of forward genetic mutagenesis screens and emerging strategies based on transgenic and antisense knockdown approaches, it should be possible to dissect the genetic programs that lead to myeloproliferative/myelodysplastic syndromes and to acute myeloid leukemia.