PUBLICATION

Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations

Authors
Imai,Y. and Talbot, W.S.
ID
ZDB-PUB-010917-4
Date
2001
Source
Genesis (New York, N.Y. : 2000)   30(3): 160-163 (Journal)
Registered Authors
Imai, Yoshiyuki, Talbot, William S.
Keywords
bmp; zebrafish; dorsoventral pattern formation; genes
MeSH Terms
  • Animals
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins/genetics*
  • Bone Morphogenetic Proteins/metabolism
  • Gene Expression Regulation, Developmental
  • Oligonucleotides, Antisense/genetics*
  • Phenotype
  • Point Mutation/genetics*
  • Transforming Growth Factor beta*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
(all 13)
PubMed
11477698 Full text @ Genesis
Abstract
Bone morphogenetic proteins (BMPs), members of the TGF-beta superfamily, are essential for dorsoventral patterning in the early embryo. In zebrafish, mutations in the bmp2b/swirl and bmp7/snailhouse genes produce dorsalized embryos in which paraxial mesoderm and the neural plate are expanded at the expense of ventral structures, demonstrating that bmp2b/swirl and bmp7/snailhouse are required for specification of ventral cell fates (Dick et al., 2000; Kishimoto et al., 1997; Mullins et al., 1996; Nguyen et al., 1998; Schmid et al., 2000). Here, we report phenotypes of bmp2b/swirl and bmp7/snailhouse mutations produced by antisense morpholino oligonucleotide injection.
Genes / Markers
Marker Marker Type Name
bmp2bGENEbone morphogenetic protein 2b
bmp7aGENEbone morphogenetic protein 7a
egr2bGENEearly growth response 2b
gata1aGENEGATA binding protein 1a
gata2aGENEGATA binding protein 2a
otx2bGENEorthodenticle homeobox 2b
pax2aGENEpaired box 2a
1 - 7 of 7
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Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
ta72a
    Point Mutation
    ty68a
      Point Mutation
      1 - 2 of 2
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      Fish
      1 - 2 of 2
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      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping