PUBLICATION
Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations
- Authors
- Imai,Y. and Talbot, W.S.
- ID
- ZDB-PUB-010917-4
- Date
- 2001
- Source
- Genesis (New York, N.Y. : 2000) 30(3): 160-163 (Journal)
- Registered Authors
- Imai, Yoshiyuki, Talbot, William S.
- Keywords
- bmp; zebrafish; dorsoventral pattern formation; genes
- MeSH Terms
-
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins/genetics*
- Bone Morphogenetic Proteins/metabolism
- Gene Expression Regulation, Developmental
- Oligonucleotides, Antisense/genetics*
- Phenotype
- Point Mutation/genetics*
- Transforming Growth Factor beta*
- Zebrafish/embryology*
- Zebrafish/genetics*
- Zebrafish Proteins/genetics
- PubMed
- 11477698 Full text @ Genesis
Citation
Imai,Y. and Talbot, W.S. (2001) Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Genesis (New York, N.Y. : 2000). 30(3):160-163.
Abstract
Bone morphogenetic proteins (BMPs), members of the TGF-beta superfamily, are essential for dorsoventral patterning in the early embryo. In zebrafish, mutations in the bmp2b/swirl and bmp7/snailhouse genes produce dorsalized embryos in which paraxial mesoderm and the neural plate are expanded at the expense of ventral structures, demonstrating that bmp2b/swirl and bmp7/snailhouse are required for specification of ventral cell fates (Dick et al., 2000; Kishimoto et al., 1997; Mullins et al., 1996; Nguyen et al., 1998; Schmid et al., 2000). Here, we report phenotypes of bmp2b/swirl and bmp7/snailhouse mutations produced by antisense morpholino oligonucleotide injection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping