Imai,Y. and Talbot, W.S. (2001) Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations. Genesis (New York, N.Y. : 2000). 30(3):160-163.
Bone morphogenetic proteins (BMPs), members of the TGF-beta superfamily, are essential for dorsoventral patterning in the early embryo. In zebrafish, mutations in the bmp2b/swirl and bmp7/snailhouse genes produce dorsalized embryos in which paraxial mesoderm and the neural plate are expanded at the expense of ventral structures, demonstrating that bmp2b/swirl and bmp7/snailhouse are required for specification of ventral cell fates (Dick et al., 2000; Kishimoto et al., 1997; Mullins et al., 1996; Nguyen et al., 1998; Schmid et al., 2000). Here, we report phenotypes of bmp2b/swirl and bmp7/snailhouse mutations produced by antisense morpholino oligonucleotide injection.