PUBLICATION
Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1
- Authors
- Mhanni, A.A., Yoder, J.A., Dubesky, C., and McGowan, R.A.
- ID
- ZDB-PUB-010822-4
- Date
- 2001
- Source
- Genesis (New York, N.Y. : 2000) 30: 213-219 (Journal)
- Registered Authors
- McGowan, Ross, Yoder, Jeffrey A.
- Keywords
- DNA cytosine-5-methyltransferase; DNA mtase; Dnmt1; zebrafish; methylation; development
- MeSH Terms
-
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA (Cytosine-5-)-Methyltransferases/chemistry
- DNA (Cytosine-5-)-Methyltransferases/genetics*
- DNA, Complementary/genetics
- Molecular Sequence Data
- Open Reading Frames/genetics
- Polymerase Chain Reaction
- Sequence Homology
- Zebrafish/genetics*
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics*
- PubMed
- 11536427 Full text @ Genesis
Citation
Mhanni, A.A., Yoder, J.A., Dubesky, C., and McGowan, R.A. (2001) Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1. Genesis (New York, N.Y. : 2000). 30:213-219.
Abstract
The zebrafish has become a well-established animal model for the analysis of development and of several disease phenotypes. Several of the favorable traits that make it a popular model organism would also be beneficial for the study of normal and abnormal vertebrate development in which DNA methylation may play a role. We report the determination of the full-length cDNA sequence corresponding to the zebrafish DNA (cytosine-5-) methyltransferase gene, Dnmt1. It is 4,907 bases long and has an open reading frame predicted to encode a 1,499 amino acid protein that is similar in size and sequence to a number of other methyltransferases identified in other organisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping