PUBLICATION

Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis

Authors
Tsai, C.W., Tseng, J.J., Lin, S.C., Chang, C.Y., Wu, J.L., Horng, J.F., and Tsay, H.J.
ID
ZDB-PUB-010705-4
Date
2001
Source
DNA and cell biology   20(5): 249-255 (Journal)
Registered Authors
Chang, Chi-Yao, Tsay, Huey-Jen, Wu, Jen-Leih
Keywords
none
MeSH Terms
  • Cloning, Molecular
  • In Situ Hybridization
  • Immunohistochemistry
  • Ganglia, Spinal/chemistry
  • Ganglia, Spinal/cytology
  • Ganglia, Spinal/metabolism
  • Retinal Ganglion Cells/chemistry
  • Retinal Ganglion Cells/metabolism
  • Animals
  • Molecular Sequence Data
  • Touch
  • Sodium Channels/chemistry*
  • Sodium Channels/genetics
  • Sodium Channels/metabolism*
  • Embryo, Nonmammalian/metabolism
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/metabolism*
  • Zebrafish Proteins*
  • Amino Acid Sequence
  • Protein Conformation
  • Phylogeny
  • Brain/metabolism
  • Superior Colliculi/chemistry
  • Superior Colliculi/metabolism
  • Neurons, Afferent/chemistry
  • Neurons, Afferent/metabolism*
(all 28)
PubMed
11410161 Full text @ DNA Cell Biol.
Abstract
A zebrafish sodium channel cDNA encoding a 1949-amino acid polypeptide, Na(v)1.6, was isolated. Two transcripts were detected in zebrafish adult brain but not in cardiac or skeletal muscle. The RNase protection analysis confirmed the neural specificity of zebrafish Na(v)1.6 24 hours postfertilization (hpf) Na(v)1.6 was expressed in the trigeminal ganglion, anterior and posterior lateral line ganglia, rhombomeres, and Rohon-Beard neurons. This preferential localization suggests that Na(v)1.6 plays an important role in tactile sensitivity. The abundance of zebrafish Na(v) 1.6 mRNA in the central and peripheral nervous systems increased markedly between 48 and 72 hpf, during the maturation of the nervous system.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Tsai, C.W., Tseng, J.J., Lin, S.C., Chang, C.Y., Wu, J.L., Horng, J.F., and Tsay, H.J. (2001) Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis. DNA and cell biology. 20(5):249-255.