PUBLICATION
Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis
- Authors
- Tsai, C.W., Tseng, J.J., Lin, S.C., Chang, C.Y., Wu, J.L., Horng, J.F., and Tsay, H.J.
- ID
- ZDB-PUB-010705-4
- Date
- 2001
- Source
- DNA and cell biology 20(5): 249-255 (Journal)
- Registered Authors
- Chang, Chi-Yao, Tsay, Huey-Jen, Wu, Jen-Leih
- Keywords
- none
- MeSH Terms
-
- Retinal Ganglion Cells/chemistry
- Retinal Ganglion Cells/metabolism
- Zebrafish Proteins*
- Embryo, Nonmammalian/metabolism
- Phylogeny
- Superior Colliculi/chemistry
- Superior Colliculi/metabolism
- Touch
- Animals
- Ganglia, Spinal/chemistry
- Ganglia, Spinal/cytology
- Ganglia, Spinal/metabolism
- Brain/metabolism
- Protein Conformation
- Neurons, Afferent/chemistry
- Neurons, Afferent/metabolism*
- Cloning, Molecular
- Immunohistochemistry
- Molecular Sequence Data
- In Situ Hybridization
- Amino Acid Sequence
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/metabolism*
- Sodium Channels/chemistry*
- Sodium Channels/genetics
- Sodium Channels/metabolism*
- PubMed
- 11410161 Full text @ DNA Cell Biol.
Citation
Tsai, C.W., Tseng, J.J., Lin, S.C., Chang, C.Y., Wu, J.L., Horng, J.F., and Tsay, H.J. (2001) Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis. DNA and cell biology. 20(5):249-255.
Abstract
A zebrafish sodium channel cDNA encoding a 1949-amino acid polypeptide, Na(v)1.6, was isolated. Two transcripts were detected in zebrafish adult brain but not in cardiac or skeletal muscle. The RNase protection analysis confirmed the neural specificity of zebrafish Na(v)1.6 24 hours postfertilization (hpf) Na(v)1.6 was expressed in the trigeminal ganglion, anterior and posterior lateral line ganglia, rhombomeres, and Rohon-Beard neurons. This preferential localization suggests that Na(v)1.6 plays an important role in tactile sensitivity. The abundance of zebrafish Na(v) 1.6 mRNA in the central and peripheral nervous systems increased markedly between 48 and 72 hpf, during the maturation of the nervous system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping