PUBLICATION
The zebrafish Nodal signal Squint functions as a morphogen
- Authors
- Chen, Y. and Schier, A.F.
- ID
- ZDB-PUB-010601-1
- Date
- 2001
- Source
- Nature 411(6837): 607-610 (Journal)
- Registered Authors
- Chen, Yu, Schier, Alexander
- Keywords
- none
- MeSH Terms
-
- Fetal Proteins
- Signal Transduction*
- Cell Communication
- Embryo, Nonmammalian
- Nodal Signaling Ligands
- Zebrafish Proteins*
- Transforming Growth Factor beta/physiology*
- Mesoderm/physiology
- T-Box Domain Proteins/genetics
- Animals
- Nodal Protein
- Intracellular Signaling Peptides and Proteins
- Morphogenesis
- Gene Expression Regulation, Developmental
- Recombinant Fusion Proteins
- Body Patterning/physiology*
- Zebrafish
- PubMed
- 11385578 Full text @ Nature
Citation
Chen, Y. and Schier, A.F. (2001) The zebrafish Nodal signal Squint functions as a morphogen. Nature. 411(6837):607-610.
Abstract
Secreted morphogens induce distinct cellular responses in a concentration-dependent manner and act directly at a distance. The existence of morphogens during mesoderm induction and patterning in vertebrates has been highly controversial, and it remains unknown whether endogenous mesoderm inducers act directly as morphogens, function locally or act through relay mechanisms. Here we test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth factor-beta signals required for mesoderm formation and patterning in zebrafish. Whereas different levels of both Squint and Cyclops can induce different downstream genes, we find that only Squint can function directly at a distance. These results indicate that Squint acts as a secreted morphogen that does not require a relay mechanism.
Errata / Notes
Erratum in: Nature 2001 Aug 2;412(6846):566.In Fig. 1 of this Letter, panels h, m and p were incorrectly labelled.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping