PUBLICATION
fgfr3 and regionalization of anterior neural tube in zebrafish
- Authors
- Sleptsova-Friedrich, I., Li, Y., Emelyanov, A., Ekker, M., Korzh, V., and Ge, R.
- ID
- ZDB-PUB-010410-7
- Date
- 2001
- Source
- Mechanisms of Development 102(1-2): 213-217 (Journal)
- Registered Authors
- Ekker, Marc, Korzh, Vladimir, Li, Yang, Sleptsova-Freidrich, Inna
- Keywords
- forebrain; ventral diencephalon; rhombomere 1; tegmentum; midbrain-hindbrain boundary; mutants; no isthmus; Acerebellar
- MeSH Terms
-
- Chromosome Mapping
- Brain/embryology
- Brain/metabolism
- Models, Genetic
- Transcription Factors/biosynthesis
- Fibroblast Growth Factor 8
- Receptors, Fibroblast Growth Factor/biosynthesis*
- Receptors, Fibroblast Growth Factor/genetics*
- Receptor, Fibroblast Growth Factor, Type 3
- Cerebellum/embryology
- Cerebellum/metabolism
- Zebrafish
- Protein Structure, Tertiary
- Spinal Cord/embryology
- Spinal Cord/metabolism
- Amino Acid Sequence
- Fibroblast Growth Factors/biosynthesis
- Molecular Sequence Data
- Zebrafish Proteins
- DNA-Binding Proteins/biosynthesis
- Tissue Distribution
- Neural Crest/embryology*
- Neural Crest/metabolism*
- Animals
- Mutation
- In Situ Hybridization
- Protein-Tyrosine Kinases*
- Superior Colliculi/metabolism
- PAX2 Transcription Factor
- PubMed
- 11287195 Full text @ Mech. Dev.
Citation
Sleptsova-Friedrich, I., Li, Y., Emelyanov, A., Ekker, M., Korzh, V., and Ge, R. (2001) fgfr3 and regionalization of anterior neural tube in zebrafish. Mechanisms of Development. 102(1-2):213-217.
Abstract
Here we describe the isolation of the zebrafish fgfr3 gene, its structure and chromosomal location. Expression in wild type embryos occurs in the axial mesoderm, the diencephalon, the anterior hindbrain and the anterior spinal cord. In the hindbrain, a differential expression of fgfr3 was detected at several levels of intensity, with the highest expression in the posterior rhombomere 1 that is morphologically distinct from the anterior part, which develops into the cerebellum. Further, analysis of fgfr3 expression in mutants deficient in the formation of the midbrain-hindbrain boundary (MHB), noi(-/-) and ace(-/-), demonstrated that in the absence of Pax2.1 and FGF8 activity, the expression domains of FGFR3 expand into the MHB, tegmentum, cerebellum and optic tectum, which are the affected structures in these mutants.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping