PUBLICATION
Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain
- Authors
- Chiang, E.F., Yan, Y.-L., Guiguen, Y., Postlethwait, J., and Chung, B.-C.
- ID
- ZDB-PUB-010404-5
- Date
- 2001
- Source
- Mol. Biol. Evol. 18(4): 542-550 (Journal)
- Registered Authors
- Chiang, Evelyn, Chung, Bon-chu, Postlethwait, John H., Yan, Yi-Lin
- Keywords
- zebrafish; gene duplication; cyp19; P450 aromatase; phylogeny; steroid
- MeSH Terms
-
- Aromatase/genetics*
- Aromatase/metabolism
- Humans
- Genetic Linkage/genetics*
- Zebrafish/genetics*
- In Situ Hybridization
- Gene Duplication
- Sequence Alignment
- Brain/anatomy & histology
- Brain/enzymology*
- Brain/physiology
- Molecular Sequence Data
- Ovary/cytology
- Ovary/enzymology*
- Ovary/physiology
- Chromosomes/genetics
- Amino Acid Sequence
- Animals
- Female
- PubMed
- 11264405 Full text @ Mol. Biol. Evol.
Citation
Chiang, E.F., Yan, Y.-L., Guiguen, Y., Postlethwait, J., and Chung, B.-C. (2001) Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol. Biol. Evol.. 18(4):542-550.
Abstract
Cytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis of estrogens, thereby controlling various physiological functions of estrogens. We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish. These genes are located in linkage groups 18 and 25, respectively. Detailed gene mapping indicated that zebrafish linkage groups 18 and 25 may have arisen from the same ancestral chromosome by a chromosome duplication event. Cyp19a is expressed mainly in the follicular cells lining the vitellogenic oocytes in the ovary during vitellogenesis. Cyp19b is expressed abundantly in the brain, at the hypothalamus and ventral telencephalon, extending to the olfactory bulbs. The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping