PUBLICATION
The establishment of Spemann's organizer and patterning of the vertebrate embryo
- Authors
- De Robertis, E.M., Larrain, J., Oelgeschlager, M., and Wessely, O.
- ID
- ZDB-PUB-010404-12
- Date
- 2000
- Source
- Nature reviews. Genetics 1(3): 171-181 (Review)
- Registered Authors
- De Robertis, Eddy
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Body Patterning*
- Glycoproteins/chemistry
- Glycoproteins/genetics
- Intercellular Signaling Peptides and Proteins*
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Vertebrates/embryology*
- PubMed
- 11252746 Full text @ Nat. Rev. Genet.
Citation
De Robertis, E.M., Larrain, J., Oelgeschlager, M., and Wessely, O. (2000) The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nature reviews. Genetics. 1(3):171-181.
Abstract
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping