PUBLICATION
Genetic analysis of vertbrate circadian rhythmicity
- Authors
- Cahill, G.
- ID
- ZDB-PUB-010131-4
- Date
- 1998
- Source
- Final Tech. Rept. : 21 p (Other)
- Registered Authors
- Cahill, Greg
- Keywords
- circadian rhythms.; vertebrates.; genetics.; biological rhythms.; image processing.; humans.; mutations.; chromosomes.; deficiencies.; toxic agents.; genes.; molecular properties.; sleep.; jet lag.; biological clocks.; pe61102f.
- MeSH Terms
- none
- PubMed
- none
Citation
Cahill, G. (1998) Genetic analysis of vertbrate circadian rhythmicity. Final Tech. Rept.. :21 p.
Abstract
The goal of this project was to develop technology needed to identify vertebrate circadian clock genes. An understanding of basic molecular mechanisms of biological clocks is important in designing treatments of the performance deficits, sleep disorders and other problems associated with jet lag, shift work, and organic circadian clock disorders in humans. A novel automated image analysis system was developed to measure circadian locomotor rhythms. This system was used to measure behavioral rhythms in zebrafish, a vertebrate organism that is useful for large scale mutagenesis screens. A screen for dominant mutations that alter the period of zebrafish locomotor rhythms was initiated, and 1500 animals with different mutagenized genomes were tested. The progeny of 40 putative mutants are being tested to determine whether they carry authentic clock mutations.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping