ZFIN ID: ZDB-PUB-010117-1
Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino
Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L.
Date: 2000
Source: Genes & Development   14(24): 3087-3092 (Journal)
Registered Authors: Burns (Erter), Caroline, Carmany-Rampey, Amanda, Fekany-Lee, Kimberly, Gonzalez, Encina, Solnica-Krezel, Lilianna, Topczewski, Jacek, Wright, Christopher V.E.
Keywords: BMP signaling; zebrafish; borozok; chordino
MeSH Terms:
  • Animals
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Proteins/genetics
  • Bone Morphogenetic Proteins/metabolism*
  • Embryo, Nonmammalian
  • Eye Proteins
  • Female
  • Gene Expression Regulation, Developmental
  • Head/abnormalities
  • Head/embryology*
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism*
  • Mesoderm/pathology
  • Mutation
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism
  • Signal Transduction
  • Tail/embryology
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins*
PubMed: 11124801 Full text @ Genes & Dev.
Spatial variations in the levels of bone morphogenetic protein (BMP) signaling are a critical determinant of dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas BMP overexpression abolishes both head and trunk development, known single and double loss-of-function mutations in BMP inhibitors have less dramatic effects. We report that combining mutations in the zebrafish genes bozozok and chordino causes a synergistic loss of head and trunk, whereas most cells express ventro-posterior markers and develop into a tail. Genetic inactivation of BMP signaling fully suppresses these defects. Thus, a remarkably simple genetic mechanism, involving a coinhibition of BMP function by the partially overlapping bozozok and chordino pathways is used to specify vertebrate head and trunk.