Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino
- Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L.
- Genes & Development 14(24): 3087-3092 (Journal)
- Registered Authors
- Burns (Erter), Caroline, Carmany-Rampey, Amanda, Fekany-Lee, Kimberly, Gonzalez, Encina, Solnica-Krezel, Lilianna, Topczewski, Jacek, Wright, Christopher V.E.
- BMP signaling; zebrafish; borozok; chordino
- MeSH Terms
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/metabolism*
- Embryo, Nonmammalian
- Eye Proteins
- Gene Expression Regulation, Developmental
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism*
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Signal Transduction
- Zebrafish Proteins*
- 11124801 Full text @ Genes & Dev.
Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L. (2000) Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. Genes & Development. 14(24):3087-3092.
Spatial variations in the levels of bone morphogenetic protein (BMP) signaling are a critical determinant of dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas BMP overexpression abolishes both head and trunk development, known single and double loss-of-function mutations in BMP inhibitors have less dramatic effects. We report that combining mutations in the zebrafish genes bozozok and chordino causes a synergistic loss of head and trunk, whereas most cells express ventro-posterior markers and develop into a tail. Genetic inactivation of BMP signaling fully suppresses these defects. Thus, a remarkably simple genetic mechanism, involving a coinhibition of BMP function by the partially overlapping bozozok and chordino pathways is used to specify vertebrate head and trunk.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes