ZFIN ID: ZDB-PUB-001218-1
Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?
Cornell, R.A. and Ohlen, T.V.
Date: 2000
Source: Current opinion in neurobiology   10(1): 63-71 (Review)
Registered Authors: Cornell, Robert
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning*
  • Central Nervous System/cytology
  • Central Nervous System/embryology*
  • Central Nervous System/metabolism
  • Conserved Sequence/genetics*
  • Conserved Sequence/physiology
  • Drosophila Proteins*
  • Drosophila melanogaster
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/physiology*
  • Signal Transduction
  • Transcription Factors
  • Vertebrates
PubMed: 10679430 Full text @ Curr. Opin. Neurobiol.
Expression of vnd in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous gene families in corresponding domains of vertebrate neurectoderm, suggests that elements of dorsoventral neural patterning have been evolutionarily conserved. However, upstream signaling pathways regulating this columnar gene expression pattern appear to have diverged significantly throughout evolution. In addition, while recent loss-of-function studies in flies and mice indicate that these three genes may have a conserved role in regional specification, there is no obvious conservation of the particular cell fates deriving from corresponding domains. The three-column expression pattern may thus represent a developmental mechanism that is more resistant to evolutionary changes than genetic events upstream or downstream of it.