PUBLICATION

Embryonic expression of a P2X3 receptor encoding gene in zebrafish

Authors
Norton, W.H., Rohr, K.B., and Burnstock, G.
ID
ZDB-PUB-001127-1
Date
2000
Source
Mechanisms of Development   99(1-2): 149-152 (Journal)
Registered Authors
Norton, Will, Rohr, Klaus
Keywords
ATP gated ion channel; Rohon-Beard cells; trigeminal; HNK-1; posterior lateral line ganglion
MeSH Terms
  • Animals
  • Gene Expression*
  • Immunohistochemistry
  • In Situ Hybridization
  • Neural Crest/embryology*
  • Phylogeny
  • Receptors, Purinergic P2/biosynthesis*
  • Receptors, Purinergic P2X3
  • Time Factors
  • Trigeminal Ganglion/metabolism*
  • Zebrafish/embryology*
PubMed
11091083 Full text @ Mech. Dev.
Abstract
From studies performed primarily in mammals, it is thought that the P2X(3) purinoreceptor is involved in mediating sensory and nociceptive signals in adult tissues. However, little is known concerning the expression or function of P2X family genes during early development. Here we describe the expression of a gene (p2x3) encoding a P2X(3) receptor during zebrafish development. We find that zebrafish p2x3 is expressed in the anlage of the trigeminal ganglion from very early stages of development, most likely in neural crest derived trigeminal cells as opposed to placode derived cells. p2x3 is also expressed in the spinal sensory Rohon-Beard cells and in the putative posterior lateral line ganglion.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping