PUBLICATION
Embryonic expression of a P2X3 receptor encoding gene in zebrafish
- Authors
- Norton, W.H., Rohr, K.B., and Burnstock, G.
- ID
- ZDB-PUB-001127-1
- Date
- 2000
- Source
- Mechanisms of Development 99(1-2): 149-152 (Journal)
- Registered Authors
- Norton, Will, Rohr, Klaus
- Keywords
- ATP gated ion channel; Rohon-Beard cells; trigeminal; HNK-1; posterior lateral line ganglion
- MeSH Terms
-
- Animals
- Gene Expression*
- Immunohistochemistry
- In Situ Hybridization
- Neural Crest/embryology*
- Phylogeny
- Receptors, Purinergic P2/biosynthesis*
- Receptors, Purinergic P2X3
- Time Factors
- Trigeminal Ganglion/metabolism*
- Zebrafish/embryology*
- PubMed
- 11091083 Full text @ Mech. Dev.
Citation
Norton, W.H., Rohr, K.B., and Burnstock, G. (2000) Embryonic expression of a P2X3 receptor encoding gene in zebrafish. Mechanisms of Development. 99(1-2):149-152.
Abstract
From studies performed primarily in mammals, it is thought that the P2X(3) purinoreceptor is involved in mediating sensory and nociceptive signals in adult tissues. However, little is known concerning the expression or function of P2X family genes during early development. Here we describe the expression of a gene (p2x3) encoding a P2X(3) receptor during zebrafish development. We find that zebrafish p2x3 is expressed in the anlage of the trigeminal ganglion from very early stages of development, most likely in neural crest derived trigeminal cells as opposed to placode derived cells. p2x3 is also expressed in the spinal sensory Rohon-Beard cells and in the putative posterior lateral line ganglion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping