PUBLICATION
The genetic basis of cardiac function: dissection by zebrafish (Danio rerio) screens
- Authors
- Warren, K.S., Wu, J.C., Pinet, F., and Fishman, M.C.
- ID
- ZDB-PUB-000906-3
- Date
- 2000
- Source
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences 355(1399): 939-944 (Journal)
- Registered Authors
- Fishman, Mark C., Warren, Kerri S.
- Keywords
- zebrafish; genetic screen; cardiac development; cardiac function; single-gene mutation; contractility disorder
- MeSH Terms
- none
- PubMed
- none
Citation
Warren, K.S., Wu, J.C., Pinet, F., and Fishman, M.C. (2000) The genetic basis of cardiac function: dissection by zebrafish (Danio rerio) screens. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 355(1399):939-944.
Abstract
The vertebrate heart differs from chordate ancestors both structurally and functionally. Genetic units of form, termed 'modules', are identifiable by mutation, both in zebrafish and mouse, and correspond to features recently acquired in evolution, such as the ventricular chamber or endothelial lining of the vessels and heart. Zebrafish (Danio rerio) genetic screens have provided a reasonably inclusive set of such genes. Normal cardiac function may also be disrupted by single-gene mutations in zebrafish. Individual mutations may perturb contractility or rhythm generation. The zebrafish mutations which principally disturb cardiac contractility fall into two broad phenotypic categories, 'dilated' and 'hypertrophic'. Interestingly, these correspond to the two primary types of heart failure in humans. These disorders of early cardiac function provide candidate genes to be examined in complex human heart diseases, including arrhythmias and heart failure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping