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ZFIN ID: ZDB-PUB-000505-9
Expression of zebrafish fkd6 in neural crest-derived glia
Kelsh, R.N., Dutton, K., Medlin, J., and Eisen, J.S.
Date: 2000
Source: Mechanisms of Development 93(1-2): 161-164 (Journal)
Registered Authors: Dutton, Kirsten, Eisen, Judith S., Kelsh, Robert
Keywords: Danio rerio; zebrafish; neural crest; Schwann cell; satellite glia; winged helix protein; transcription factor; forkhead
MeSH Terms:
  • Animals
  • Base Sequence
  • Cell Differentiation
  • DNA, Complementary
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/physiology
  • Forkhead Transcription Factors
  • Ganglia, Spinal/metabolism
  • Gene Expression
  • Molecular Sequence Data
  • Neural Crest/cytology*
  • Neural Crest/metabolism
  • Neuroglia/metabolism*
  • Schwann Cells
  • Transcription Factors/genetics*
  • Transcription Factors/physiology
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 10781949 Full text @ Mech. Dev.
The zebrafish fkd6 gene is a marker for premigratory neural crest. In this study, we analyze later expression in putative glia of the peripheral nervous system. Prior to neural crest migration, fkd6 expression is downregulated in crest cells. Subsequently, expression appears initially in loose clusters of cells in positions corresponding to cranial ganglia. Double labelling with a neuronal marker shows that fkd6-expressing cells are not differentiated neurones and generally lie peripheral to neurones in ganglia. Later, expression appears associated with the posterior lateral line and other cranial nerves. For the posterior lateral line nerve, we show that fkd6-labeling extends caudally along this nerve in tight correlation with lateral line primordium migration and axon elongation. Expression in colourless mutant embryos is consistent with these cells being satellite glia and Schwann cells.