|ZFIN ID: ZDB-PUB-000505-19|
Zebrafish developmental genetics and central nervous system development
Blader, P. and Strähle, U.
|Source:||Human molecular genetics 9(6): 945-951 (Journal)|
|Registered Authors:||Blader, Patrick, Strähle, Uwe|
|PubMed:||10767318 Full text @ Hum. Mol. Genet.|
Blader, P. and Strähle, U. (2000) Zebrafish developmental genetics and central nervous system development. Human molecular genetics. 9(6):945-951.
ABSTRACTThe central nervous system (CNS) is the most complex tissue of vertebrates. Recently, the zebrafish has emerged as a powerful genetic system for studying early development, and large-scale mutagenic screens for embryonic patterning defects have been accomplished. Mutants isolated in these screens are proving helpful in unravelling the mole-cular hierarchies involved in the development of the CNS. We review here recent studies in zebrafish which shed light on the genetic pathways involved in induction and regionalization of the CNS.
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