ZFIN ID: ZDB-PERS-991129-1
Gong, Hong-Yi
Email: hygong@mail.ntou.edu.tw
Affiliation: Hong-Yi Gong Lab
Address: Division of Life Science Department of Aquaculture, College of Life Sciences National Taiwan Ocean University Keelung, 20224 Taiwan
Country: Taiwan
Phone: 886-2-24622192 ext. 5224

2008~ Assistant Professor, Division of Life Science, Department of Aquaculture, National Taiwan Ocean University, Taiwan
2004~2008 Post-doctoral Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
2004 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center, Taiwan

My current research activities focus on the following areas:
(1) Functional genomics approach to study regulatory mechanism of growth factors and transcription factors involved in the growth of teleosts; (2) Establishment of functional genes as molecular markers of breeding to improve broodstock of the grouper and tilapia for growth promotion and disease-resistance; (3) Development of muscle-specific promoter/enhancer applied in transgenic fish to study functional genes in fish muscle growth and regeneration and to use fish muscle as bioreactor to produce interested proteins; (4) Zebrafish as an animal model to investigate molecular mechanisms of liver development and human liver diseases from steatosis to liver cancers.

Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
Wu, S.H., Chou, H.Y., Liu, P.C., Wu, J.L., Gong, H.Y. (2019) Granulin peptide GRN-41 of Mozambique tilapia is a novel antimicrobial peptide against Vibrio species. Biochemical and Biophysical Research Communications. 515(4):706-711
Wu, S.H., Lin, H.J., Lin, W.F., Wu, J.L., Gong, H.Y. (2018) A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & shellfish immunology. 75:74-90
Huang, S.J., Cheng, C.L., Chen, J.R., Gong, H.Y., Liu, W., Wu, J.L. (2017) Inducible liver-specific overexpression of gankyrin in zebrafish results in spontaneous intrahepatic cholangiocarcinoma and hepatocellular carcinoma formation. Biochemical and Biophysical Research Communications. 490(3):1052-1058
Pan, C.Y., Liu, Y.H., Gong, H.Y., Chen, J.Y. (2017) Transcriptome analysis of the effect of polyunsaturated fatty acids against Vibrio vulnificus infection in Oreochromis niloticus. Fish & shellfish immunology. 62:153-163
Cheng, C.L., Huang, S.J., Wu, C.L., Gong, H.Y., Ken, C.F., Hu, S.Y., Wu, J.L. (2015) Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection. Journal of Biomedical Science. 22:103
Huang, S.H., Huang, K.S., Yu, C.H., and Gong, H.Y. (2013) Metabolic profile analysis of a single developing zebrafish embryo via monitoring of oxygen consumption rates within a microfluidic device. Biomicrofluidics. 7(6):64107
Li, Y.H., Chen, H.Y., Li, Y.W., Wu, S.Y., Wangta, L., Lin, G.H., Hu, S.Y., Chang, Z.K., Gong, H.Y., Liao, C.H., Chiang, K.Y., Huang, C.W., and Wu, J.L. (2013) Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells. Scientific Reports. 3:1176
Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21
Wang, W.L., Hong, J.R., Lin, G.H., Liu, W., Gong, H.Y., Lu, M.W., Lin, C.C., and Wu, J.L. (2011) Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells. PLoS One. 6(2):e16740
Hu, S.Y., Liao, C.H., Lin, Y.P., Li, Y.H., Gong, H.Y., Lin, G.H., Kawakami, K., Yang, T.H., and Wu, J.L. (2011) Zebrafish eggs used as bioreactors for the production of bioactive tilapia insulin-like growth factors. Transgenic Research. 20(1):73-83
Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009
Hu, S.Y., Lin, P.Y., Liao, C.H., Gong, H.Y., Lin, G.H., Kawakami, K., and Wu, J.L. (2010) Nitroreductase-mediated Gonadal Dysgenesis for Infertility Control of Genetically Modified Zebrafish. Marine biotechnology (New York, N.Y.). 12(5):569-578
Lee, C.Y., Hu, S.Y., Gong, H.Y., Chen, M.H., Lu, J.K., and Wu, J.L. (2009) Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish. Biochemical and Biophysical Research Communications. 387(4):766-771
Hu, S.Y., Chen, M.H., Lin, Y.C., Lin, G.H., Gong, H.Y., and Wu, J.L. (2008) Cloning and functional analysis of the proximal promoter region of the three GnRH genes from the silver sea bream (Sparus sarba). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 151(4):373-380
Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Rekha, R.D., Lu, J.K., Chen, T.T., and Wu, J.L. (2008) Overexpression of Myostatin2 in zebrafish reduces the expression of dystrophin associated protein complex (DAPC) which leads to muscle dystrophy. Journal of Biomedical Science. 15(5):595-604
Wu, H.C., Chiu, C.S., Wu, J.L., Gong, H.Y., Chen, M.C., Lu, M.W., and Hong, J.R. (2008) Zebrafish anti-apoptotic protein zfBcl-x(L) can block betanodavirus protein alpha-induced mitochondria-mediated secondary necrosis cell death. Fish & shellfish immunology. 24(4):436-449
Rekha, R.D., Amali, A.A., Her, G.M., Yeh, Y.H., Gong, H.Y., Hu, S.Y., Lin, G.H., and Wu, J.L. (2008) Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio. Toxicology. 243(1-2):11-22
Hu, M.C., Gong, H.Y., Lin, G.H., Hu, S.Y., Chen, M.H., Huang, S.J., Liao, C.F., and Wu, J.L. (2007) XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Biochemical and Biophysical Research Communications. 359(3):778-783
Chou, M.J., Chen, J.C., Chen, J.Y., Gong, H.Y., Li, L.T., Huang, T.C., Wu, J.L., and Kuo, C.M. (2006) Isolation and characterization of the zebrafish Danio rerio insulin-like growth factor binding protein-3 promoter region. Fisheries science : FS. 74:153-166
Amali, A.A., Rekha, R.D., Lin, C.J., Wang, W.L., Gong, H.Y., Her, G.M., and Wu, J.L. (2006) Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. Journal of Biomedical Science. 13(2):225-232
Chen, J.Y., Chou, M.J., Gong, H.Y., Huang, T.C., Wu, J.L., and Kuo, C.M. (2005) Cloning and Biological Analysis of the Zebrafish (Danio rerio) Insulin-Like Growth Factor Binding Protein-2 Proximal Promoter Region. DNA and cell biology. 24(3):199-208
Gong, H.Y., Lin, C.J., Chen, M.H., Hu, M.C., Lin, G.H., Zhou, Y., Zon, L.I., and Wu, J.L. (2004) Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene. 338(1):35-46
Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Lee, C.Y., Ko, Y.L., Lu, J.K., Her, G.M., Chen, T.T., and Wu, J.L. (2004) Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Developmental dynamics : an official publication of the American Association of Anatomists. 229(4):847-856
Huang, W.T., Gong, H.Y., Lin, C.J., Weng, C.F., Chen, M.H., and Wu, J.L. (2001) Hepatocyte nuclear factors-1alpha, -1beta, and -3beta expressed in the gonad of tilapia (Oreochromis mossambicus). Biochemical and Biophysical Research Communications. 288(4):833-840
Chen, M., Gong, H., Cheng, C., Wang, J., Hong, J., and Wu, J. (2001) Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. BBA Gene Structure and Expression. 1519(1-2):127-133
Chen, M.H., Lin, G., Gong, H., Weng, C., Chang, C., and Wu, J. (2001) The characterization of prepro-Insulin-like growth factor-1 Ea-2 expression and Insulin-like growth factor-1 genes (devoid 81 bp) in the zebrafish (Danio rerio). Gene. 268(1-2):67-75
Chen, M.C., Gong, H.Y., Cheng, C.Y., Wang, J.P., Hong, J.R., and Wu, J.L. (2000) Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochemical and Biophysical Research Communications. 279(2):725-731

Hu, S. Y., Chen, M. H. C., Lin, Y. C., Lin, G. H., Gong, H. Y., Wu, J. L. (2008). Cloning and functional analysis of the proximal promoter region of the three GnRH genes from silver sea bream (Sparus sarba). Comparative Biochemistry and Physiology B Biochem. Mol. Biol. 151: 373-380.

Lin, C. J. F., Gong, H. Y., Tseng, H. C., Wang, W. L., Wu, J. L. (2008). miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem. Bioph. Res. Co. 375: 315-320.

Huang, W. T., Yu, H. C., Hsu, C. C., Liao, C. F., Gong, H. Y., Lin, C. J. F., Wu, J. L., and Weng, C. F. (2007). Steroid hormones (17beta-estradiol and hydrocortisone) upregulate hepatocyte nuclear factor (HNF)-3beta and insulin-like growth factor I and II expression in the gonads of tilapia (Oreochromis mossambicus) in vitro. Theriogenology 68: 988-1002.

Chen, M. H. C., Li, Y. H., Chang, Y., Hu, S. Y., Gong, H. Y. , Lin, G. H., Chen, T. T. and Wu, J. L. (2007). Co-induction of hepatic IGF-1 and progranulin mRNA by growth hormone in tilapia (Oreochromis mossambicus). General Comparative Endocrinology 150: 212-218.

Hu, S. Y., Huang, J. H., Huang, W. T., Yeh, Y. H., Chen, M. H. C., Gong, H. Y. , Chiou T. T., Yang, T. H., Chen, T. T., Lu, J. K. and Wu, J. L. (2006). Structure and function of antimicrobial peptide penaeidin-5 from the black tiger shrimp Penaeus monodon. Aquaculture 260: 61-68.

Gong, H. Y., Wu, J. L., Huang, W. T., Lin, C. J. F., and Weng, C. F. (2004). Response to acute changes in salinity of two different muscle type creatine kinase isoforms, from euryhaline teleost (Oreochromis mossambicus) gills. Bioch. Biophy. Acta 1675: 184-191.

Lin, L.Y., Chiang, C.C., Gong, H.Y., Cheng, C.Y., Hwang, P.P. and Weng, C.F. (2003). Cellular Distributions of Creatine Kinase in Branchia of Euryhaline Tilapia (Oreochromis mossambicus). Am J Physiol Cell Physiol 284: C233¡VC241.

Hong, J.R., Gong, H.Y. and Wu, J.L. (2002). IPNV VP5, a novel anti-apoptosis of Bcl-2 family, regulates Mcl-1 and viral protein expression. Virology 295: 217-229.

Weng, C.F., Chiang, C.C., Gong, H.Y., Chen, M.H.C., Lin, C.J.F., Hwang, P.P. and Wu, J.L. (2002). Acute branchial response to salinity changes in euryhaline teleost (Oreochromis mossambicus). Physiol. and Biochem. Zool. 75: 29-36.

Weng, C.F., Chiang, C.C., Gong, H.Y., Chen, M.H.C., Huang, W.T., Cheng, C.Y. and Wu, J.L. (2002).Bioenergetics of adaptation to a salinity transition in euryhaline teleost (Oreochromis mossambicus) brain. Exp. Biol. Med. 227: 45-50.

Huang, W.T., Gong, H.Y., Lin, C.J., Weng, C.F., Chen, M.H., and Wu, J.L. (2001) Hepatocyte nuclear factors-1alpha, -1beta, and -3beta expressed in the gonad of tilapia (Oreochromis mossambicus). Biochem. Biophys. Res. Commun.. 288(4):833-840

Weng, C.F., Gong, H.Y., Wu, J.L., Hew, C.L. and Hwang, P.P. (2000). Antagonizing effects of type I antifreeze protein on Ca++ uptake in fish TO2 cells. Zool. Stud. 39:144-150.

Chen, M. H.C., Lin, G.H., Gong, H.Y., Lee, C.Y., Chang, C.Y., Chen, T.T. and Wu, J.L. (1998). Cloning and characterization of insulin-like growth factor I cDNA from black seabream (Acanthopagrus schlegeli). Zool. Stud. 37: 213-221.