ZFIN Person: Obara, Tomoko

ZFIN ID: ZDB-PERS-991029-1

Obara, Tomoko

Email:	tomoko.obara@gmail.com
URL:	http://www.oumedicine.com/body.cfm?id=4843
Affiliation:	Obara Lab
Address:	Dept. of Cell Biology University of Oklahoma Science Center 975 NE 10th St. BRC Room 256 Oklahoma City, OK 73104 USA
Country:	United States
Phone:	(405) 271-8001, ext. 47035
Fax:	(405) 271-3548
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Powell, R., Bubenshchikova, E., Fukuyo, Y., Hsu, C., Lakiza, O., Nomura, H., Renfrew, E., Garrity, D., Obara, T. (2016) Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish. Molecular Medicine Reports. 14(3):2665-78

Walter, R.B., Obara, T. (2015) Workshop Report: The Medaka Model for Comparative Assessment of Human Disease Mechanisms. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 178:156-62

Fukuyo, Y., Nakamura, T., Bubenshchikova, E., Powell, R., Tsuji, T., Janknecht, R., and Obara, T. (2014) Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Molecular Medicine Reports. 9(2):457-465

Ichimura, K., Powell, R., Nakamura, T., Kurihara, H., Sakai, T., and Obara, T. (2013) Podocalyxin regulates pronephric glomerular development in zebrafish. Physiological Reports. 1(3):e00074

Ichimura, K., Fukuyo, Y., Nakamura, T., Powell, R., Sakai, T., Janknecht, R., and Obara, T. (2013) Developmental Localization of Nephrin in Zebrafish and Medaka Pronephric Glomerulus. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 61(4):313-324

Ichimura, K., Fukuyo, Y., Nakamura, T., Powell, R., Sakai, T., and Obara, T. (2012) Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant. Developmental dynamics : an official publication of the American Association of Anatomists. 241(12):1922-1932

Bubenshchikova, E., Ichimura, K., Fukuyo, Y., Powell, R., Hsu, C., Morrical, S.O., Sedor, J.R., Sakai, T., and Obara, T. (2012) Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biology Open. 1(6):588-596

Ichimura, K., Bubenshchikova, E., Powell, R., Fukuyo, Y., Nakamura, T., Tran, U., Oda, S., Tanaka, M., Wessely, O., Kurihara, H., Sakai, T., and Obara, T. (2012) A comparative analysis of glomerulus development in the pronephros of medaka and zebrafish. PLoS One. 7(9):e45286

Kim, S., Zaghloul, N.A., Bubenshchikova, E., Oh, E.C., Rankin, S., Katsanis, N., Obara, T., and Tsiokas, L. (2011) Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nature cell biology. 13(4):351-60

Giamarchi, A., Feng, S., Rodat-Despoix, L., Xu, Y., Bubenshchikova, E., Newby, L.J., Hao, J., Gaudioso, C., Crest, M., Lupas, A.N., Honoré, E., Williamson, M.P., Obara, T., Ong, A.C., and Delmas, P. (2010) A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. The EMBO journal. 29(7):1176-1191

Feng, S., Okenka, G.M., Bai, C.X., Streets, A.J., Newby, L.J., Dechant, B.T., Tsiokas, L., Obara, T., and Ong, A.C. (2008) Identification and functional characterisation of an N-terminal oligomerisation domain for polycystin-2. The Journal of biological chemistry. 283(42):28471-28479

Pathak, N., Obara, T., Mangos, S., Liu, Y., and Drummond, I.A. (2007) The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation. Molecular biology of the cell. 18(11):4353-4364

Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., and Drummond, I.A. (2006) Polycystin-2 Immunolocalization and Function in Zebrafish. Journal of the American Society of Nephrology : JASN. 17(10):2706-2718

Streets, A.J., Moon, D.J., Kane, M.E., Obara, T., and Ong, A.C. (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro. Human molecular genetics. 15(9):1465-1473

Low, S.H., Vasanth, S., Larson, C.H., Mukherjee, S., Sharma, N., Kinter, M.T., Kane, M.E., Obara, T., and Weimbs, T. (2006) Polycystin-1, STAT6, and P100 Function in a Pathway that Transduces Ciliary Mechanosensation and Is Activated in Polycystic Kidney Disease. Developmental Cell. 10(1):57-69

Bedell, V.M., Yeo, S.Y., Park, K.W., Chung, J., Seth, P., Shivalingappa, V., Zhao, J., Obara, T., Sukhatme, V.P., Drummond, I.A., Li, D.Y., and Ramchandran, R. (2005) roundabout4 is essential for angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102(18):6373-6378

Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Kronig, C., Schermer, B., Benzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., and Walz, G. (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nature Genetics. 37(5):537-543

Otto, E.A., Schermer, B., Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Ruf, R.G., Hoefele, J., Beekmann, F., Landau, D., Foreman, J.W., Goodship, J.A., Strachan, T., Kispert, A., Wolf, M.T., Gagnadoux, M.F., Nivet, H., Antignac, C., Walz, G., Drummond, I.A., Benzing, T., and Hildebrandt, F. (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics. 34(4):413-420

Liu, S., Lu, W., Obara, T., Kuida, S., Lehoczky, J., Dewar, K., Drummond, I.A., and Beier, D.R. (2002) A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (Cambridge, England). 129(24):5839-5846

Liu, S., Obara-Ishihara, T., Drummond, I.A., and Beier, D.R. (2002) Characterization of Nek8, the gene mutated in the jck mouse model of polycystic kidney disease. Journal of the American Society of Nephrology : JASN. 13:116A

NON-ZEBRAFISH PUBLICATIONS