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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-990607-20
Ober, Elke
Email: elke.ober@sund.ku.dk
URL:
Affiliation: Ober Lab
Address: The Danish Stem Cell Centre (DanStem)
 University of Copenhagen
 Blegdamsvej 3B DK-2200, Copenhagen N
 Denmark
Country: United Kingdom
Phone: +45 23 64 87 82
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Our group is interested in understanding organ formation in vertebrates, with focus on the liver as part of the digestive system. We are using the zebrafish Danio rerio as model organism to study the complex processes underlying the development of the liver, since it is amenable to a wide range of embryonic and genetic techniques. Moreover, in contrast to other vertebrates, the liver is not site of hematopoiesis in fish allowing to investigate hepatic development independently of defects due to anemia.


PUBLICATIONS
Wang, S., Miller, S.R., Ober, E.A., Sadler, K.C. (2017) Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research. Current topics in developmental biology. 124:161-195
Cayuso, J., Dzementsei, A., Fischer, J.C., Karemore, G., Caviglia, S., Bartholdson, J., Wright, G.J., Ober, E.A. (2016) EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell. 39:316-328
Koltowska, K., Lagendijk, A.K., Pichol-Thievend, C., Fischer, J.C., Francois, M., Ober, E.A., Yap, A.S., Hogan, B.M. (2015) Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports. 13:1828-41
van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (Cambridge, England). 141(6):1228-1238
Markmiller, S., Cloonan, N., Lardelli, R.M., Doggett, K., Keightley, M.C., Boglev, Y., Trotter, A.J., Ng, A.Y., Wilkins, S.J., Verkade, H., Ober, E.A., Field, H.A., Grimmond, S.M., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2014) Minor class splicing shapes the zebrafish transcriptome during development. Proceedings of the National Academy of Sciences of the United States of America. 111(8):3062-3067
Dunworth, W.P., Cardona-Costa, J., Cagavi, E., Kim, J.D., Fischer, J.C., Meadows, S., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.W. (2014) Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation research. 114(1):56-66
Koltowska, K., Apitz, H., Stamataki, D., Hirst, E.M., Verkade, H., Salecker, I., and Ober, E.A. (2013) Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development (Cambridge, England). 140(9):1912-8
Boglev, Y., Badrock, A.P., Trotter, A.J., Du, Q., Richardson, E.J., Parslow, A.C., Markmiller, S.J., Hall, N.E., de Jong-Curtain, T.A., Ng, A.Y., Verkade, H., Ober, E.A., Field, H.A., Shin, D., Shin, C.H., Hannan, K.M., Hannan, R.D., Pearson, R.B., Kim, S.H., Ess, K.C., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2013) Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genetics. 9(2):e1002379
Schaub, M., Nussbaum, J., Verkade, H., Ober, E.A., Stainier, D.Y., and Sakaguchi, T.F. (2012) Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network. Developmental Biology. 363(1):128-137
Poulain, M., and Ober, E.A. (2011) Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development (Cambridge, England). 138(16):3557-68
Mas, J.C., Noël, E.S., and Ober, E.A. (2011) Chromatin modification in zebrafish development. Methods in cell biology. 104:401-428
Noël, E.S., Reis, M.D., Arain, Z., and Ober, E.A. (2010) Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation. Gene expression patterns : GEP. 10(6):237-243
Curado, S., Ober, E.A., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C.M., and Stainier, D.Y. (2010) The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Disease models & mechanisms. 3(7-8):486-495
Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S.W., Verkade, H., Holtzman, N.G., Yelon, D., and Stainier, D.Y. (2008) The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Current biology : CB. 18(23):1882-1888
Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y. (2008) Regulation of neurocoel morphogenesis by Pard6gammab. Developmental Biology. 324(1):41-54
Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250
Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y. (2008) Multiple roles for Med12 in vertebrate endoderm development. Developmental Biology. 317(2):467-479
Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42
Shin, D., Shin, C.H., Tucker, J., Ober, E.A., Rentzsch, F., Poss, K.D., Hammerschmidt, M., Mullins, M.C., and Stainier, D.Y. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development (Cambridge, England). 134(11):2041-2050
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Ober, E.A., Verkade, H., Field, H.A., and Stainier, D.Y. (2006) Mesodermal Wnt2b signalling positively regulates liver specification. Nature. 442(7103):688-691
Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
Ober, E.A., Olofsson, B., Makinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., and Stainier, D.Y. (2004) Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO reports. 5(1):78-84
Loosli, F., Staub, W., Finger-Baier, K.C., Ober, E.A., Verkade, H., Wittbrodt, J., and Baier, H. (2003) Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO reports. 4(9):894-899
Field, H.A., Ober, E.A., Roeser, T., and Stainier, D.Y. (2003) Formation of the digestive system in zebrafish. I. Liver morphogenesis. Developmental Biology. 253(2):279-290
Ober, E.A., Field, H.A., and Stainier, D.Y. (2003) From endoderm formation to liver and pancreas development in zebrafish. Mechanisms of Development. 120(1):5-18
Ober, E.A. and Schulte-Merker, S. (1999) Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish. Developmental Biology. 215(2):167-181
Münchberg, S.R., Ober, E.A., and Steinbeisser, H. (1999) Expression of the Ets transcription factors erm and pea3 in early zebrafish development. Mechanisms of Development. 88(2):233-236

NON-ZEBRAFISH PUBLICATIONS