ZFIN Person: Rinkwitz, Silke

ZFIN ID: ZDB-PERS-990427-1

ZFIN ID: ZDB-PERS-990427-1

Rinkwitz, Silke

Email:	silke.rinkwitz@sydney.edu.au
URL:
Affiliation:	Becker Lab
Address:	Senior Research Fellow Developmental Neurobiology and Genomics Brain and Mind Research Institute Building K, Level 3 100 Mallet Street Camperdown, NSW 2050 Australia
Country:	Australia
Phone:	+61293510866
Fax:	+61-293510731
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Watchon, M., Yuan, K.C., Mackovski, N., Svahn, A.J., Cole, N.J., Goldsbury, C., Rinkwitz, S., Becker, T.S., Nicholson, G.A., Laird, A.S. (2017) Calpain inhibition is protective in Machado-Joseph disease zebrafish due to induction of autophagy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(32):7782-7794

Mechaly, A.S., Richardson, E., Rinkwitz, S. (2017) Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. General and comparative endocrinology. 246:233-240

Giacomotto, J., Carroll, A.P., Rinkwitz, S., Mowry, B., Cairns, M.J., Becker, T.S. (2016) Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish. Translational psychiatry. 6:e818

Svahn, A.J., Giacomotto, J., Graeber, M.B., Rinkwitz, S., Becker, T.S. (2016) miR-124 contributes to the functional maturity of microglia. Developmental Neurobiology. 76(5):507-18

Laird, A.S., Mackovski, N., Rinkwitz, S., Becker, T.S., Giacomotto, J. (2016) Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages. Human molecular genetics. 25(9):1728-38

Abu-Siniyeh, A., Owen, D.M., Benzing, C., Rinkwitz, S., Becker, T.S., Majumdar, A., Gaus, K. (2016) The aPKC/Par3/Par6 polarity complex and membrane order are functionally inter-dependent in epithelia during vertebrate organogenesis. Traffic (Copenhagen, Denmark). 17(1):66-79

Ishibashi, M., Manning, E., Shoubridge, C., Krecsmarik, M., Hawkins, T.A., Giacomotto, J., Zhao, T., Mueller, T., Bader, P.I., Cheung, S.W., Stankiewicz, P., Bain, N.L., Hackett, A., Reddy, C.C., Mechaly, A.S., Peers, B., Wilson, S.W., Lenhard, B., Bally-Cuif, L., Gecz, J., Becker, T.S., Rinkwitz, S. (2015) Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene. Human genetics. 134(11-12):1163-82

Greenlees, R., Mihelec, M., Yousoof, S., Speidel, D., Wu, S.K., Rinkwitz, S., Prokudin, I., Perveen, R., Cheng, A., Ma, A., Nash, B., Gillespie, R., Loebel, D.A., Clayton-Smith, J., Lloyd, I.C., Grigg, J.R., Tam, P.P., Yap, A.S., Becker, T.S., Black, G.C., Semina, E., Jamieson, R.V. (2015) Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Human molecular genetics. 24(20):5789-804

Rinkwitz, S., Geng, F., Manning, E., Suster, M., Kawakami, K., Becker, T.S. (2015) BAC transgenic zebrafish reveal hypothalamic enhancer activity around obesity associated SNP rs9939609 within the human FTO gene. Genesis (New York, N.Y. : 2000). 53(10):640-51

Giacomotto, J., Rinkwitz, S., Becker, T.S. (2015) Effective heritable gene knockdown in zebrafish using synthetic microRNAs. Nature communications. 6:7378

Punnamoottil, B., Rinkwitz, S., Giacomotto, J., Svahn, A.J., Becker, T.S. (2015) Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of SLIT2/3 genes. Genesis (New York, N.Y. : 2000). 53(5):321-8

Naville, M., Ishibashi, M., Ferg, M., Bengani, H., Rinkwitz, S., Krecsmarik, M., Hawkins, T.A., Wilson, S.W., Manning, E., Chilamakuri, C.S., Wilson, D.I., Louis, A., Lucy Raymond, F., Rastegar, S., Strähle, U., Lenhard, B., Bally-Cuif, L., van Heyningen, V., FitzPatrick, D.R., Becker, T.S., Roest Crollius, H. (2015) Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. Nature communications. 6:6904

Chang, G.H., Lay, A.J., Ting, K.K., Zhao, Y., Coleman, P.R., Powter, E.E., Formaz-Preston, A., Jolly, C.J., Bower, N.I., Hogan, B.M., Rinkwitz, S., Becker, T.S., Vadas, M.A., Gamble, J.R. (2014) ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases. 5(3):1-15

Maley, D., Laird, A.S., Rinkwitz, S., and Becker, T.S. (2013) A Simple and Efficient Protocol for the Treatment of Zebrafish Colonies Infected with Parasitic Nematodes. Zebrafish. 10(3):447-50

Ishibashi, M., Mechaly, A.S., Becker, T.S., and Rinkwitz, S. (2013) Using zebrafish transgenesis to test human genomic sequences for specific enhancer activity. Methods (San Diego, Calif.). 62(3):216-25

Svahn, A.J., Graeber, M.B., Ellett, F., Lieschke, G.J., Rinkwitz, S., Bennett, M.R., and Becker, T.S. (2013) Development of ramified microglia from early macrophages in the zebrafish optic tectum. Developmental Neurobiology. 73(1):60-71

Djiotsa, J., Verbruggen, V., Giacomotto, J., Ishibashi, M., Manning, E., Rinkwitz, S., Manfroid, I., Lvoz, M., and Peers, B. (2012) Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Developmental Biology. 12(1):37

Becker, T.S., and Rinkwitz, S. (2012) Zebrafish as a genomics model for human neurological and polygenic disorders. Developmental Neurobiology. 72(3):415-428

Sundström, E., Komisarczuk, A.Z., Jiang, L., Golovko, A., Navratilova, P., Rinkwitz, S., Becker, T.S., and Andersson, L. (2012) Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment cell & melanoma research. 25(1):28-36

Rinkwitz, S., Mourrain, P., and Becker, T.S. (2011) Zebrafish: an integrative System for Neurogenomics and Neurosciences. Prog. Neurobiol.. 93(2):231-243

Punnamoottil, B., Herrmann, C., Pascual Anaya, J., D'Aniello, S., Garcia-Fernàndez, J., Akalin, A., Becker, T.S., and Rinkwitz, S. (2010) Cis-regulatory characterization of sequence conservation surrounding the Hox4 genes. Developmental Biology. 340(2):269-282

Ma, L.H., Punnamoottil, B., Rinkwitz, S., and Baker, R. (2009) Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain. PLoS One. 4(6):e5944

Punnamoottil, B., Kikuta, H., Pezeron, G., Erceg, J., Becker, T.S., and Rinkwitz, S. (2008) Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(8):2195-2208

Rinkwitz, S., Laplante, M., Kikuta, H., and Becker, T.S. (2007) A large-scale zebrafish enhancer screen. ZFIN Direct Data Submission.

Kikuta, H., Fredman, D., Rinkwitz, S., Lenhard, B., and Becker, T.S. (2007) Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes. Genome biology. 8(1):S4

Hadrys, T., Punnamoottil, B., Pieper, M., Kikuta, H., Pezeron, G., Becker, T.S., Prince, V., Baker, R., and Rinkwitz, S. (2006) Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Developmental Biology. 297(1):26-43

Hadrys, T., Prince, V., Hunter, M., Baker, R., and Rinkwitz, S. (2004) Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. The Journal of experimental zoology. 302(2):147-164

NON-ZEBRAFISH PUBLICATIONS
Bober, E., Rinkwitz, S. & Herbrand, H. (2003). Molecular basis of otic commitment and morphogenesis: a role for homeodomain-containing transcription factors and signaling molecules. Curr. Top. Dev. Biol. 57, 151-175.

Merlo, G. R., Paleari, S., Mantero, S., Zerega, B., Adamska, M., Rinkwitz, S., Bober, E., and Levi, G. (2002). The Dlx5 Homeobox gene is essential for vestibular morphogenesis in the mouse embryo through BMP4-mediated pathway. Dev Biol. 248 (1), 157-69

Rinkwitz, S., Bober, E. & Baker, R. (2001). Development of the Inner Ear. Ann N Y Acad Sci. 942, 1-14.

Rinkwitz-Brandt, S. (1999). Molecular processes during inner ear development. B.I.F. Futura 14, 150-153.

Hadrys, T., Braun, T., Rinkwitz-Brandt, S., Arnold, H.H. and Bober, E. (1998). Nkx5-1 controls semicircular canal formation in the mouse inner ear. Development 125, 33-39.

Herbrand, H., Guthrie, S., Hadrys, T., Hoffmann, S., Arnold, H.H., Rinkwitz-Brandt, S. and Bober, E. (1998). Two regulatory genes, cNkx5.1 homeobox gene and Pax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo. Development 125, 645-654.

Rinkwitz-Brandt, S., Arnold, H. H. and Bober, E. (1996). Regionalized expression of Nkx-5.1, Nkx-5.2, Pax-2 and sek genes during inner ear development. Hearing Research 99, 129-138.

Rinkwitz-Brandt, S., Justus, M., Oldenettel, I., Arnold, H. H., Bober, E. (1995). Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Mech. Dev. 52, 371-381.

Freter, S., Muta, Y., Mak, S. S., Rinkwitz, S., Ladher, R. K. (2008). Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential. Dev.,135, 3415-3424.