header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-981015-2
Hukriede, Neil
Email: hukriede@pitt.edu
URL: http://www.mgb.pitt.edu/personnel/Hukriede_Neil.htm
Affiliation: Hukriede Lab
Address: Department of Molecular Genetics and Biochemistry University of Pittsburgh School of Medicine W1256 Biomedical Sciences Tower Pittsburgh, PA 15261 USA
Country: United States
Phone: (412) 648-9918
Fax: (412) 624-1401
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Nau, G.J., Horzempa, J., O'Dee, D., Brown, M.J., Russo, B.C., Hernandez, A., Dillon, S.T., Cheng, J., Kane, L.P., Sanker, S., Hukriede, N.A. (2019) A predicted Francisella tularensis DXD-motif glycosyltransferase blocks immune activation. Virulence. 10:643-656
Espiritu, E.B., Jiang, H., Moreau-Marquis, S., Sullivan, M., Yan, K., Beer Stolz, D., Sampson, M.G., Hukriede, N.A., Swiatecka-Urban, A. (2019) The human nephrin Y1139RSL motif is essential for podocyte foot process organization and slit diaphragm formation during glomerular development. The Journal of biological chemistry. 294(28):10773-10788
Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
Skvarca, L.B., Han, H.I., Espiritu, E.B., Missinato, M.A., Rochon, E.R., McDaniels, M.D., Bais, A.S., Roman, B.L., Waxman, J.S., Watkins, S.C., Davidson, A.J., Tsang, M., Hukriede, N.A. (2019) Enhancing acute kidney injury regeneration by promoting cellular dedifferentiation in zebrafish. Disease models & mechanisms. 12(4):
Wen, X., Cui, L., Morrisroe, S., Maberry, D., Emlet, D.R., Watkins, S.C., Hukriede, N.A., Kellum, J.A. (2018) A zebrafish model of infection-associated acute kidney injury. American journal of physiology. Renal physiology. 315(2):F291-F299
Han, H.I., Skvarca, L.B., Espiritu, E.B., Davidson, A.J., Hukriede, N.A. (2018) The role of macrophages during acute kidney injury: destruction and repair. Pediatric nephrology (Berlin, Germany). 34(4):561-569
Shun, T., Gough, A.H., Sanker, S., Hukriede, N.A., Vogt, A. (2017) Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos. Assay and drug development technologies. 15(6):257-266
Hukriede, N., Vogt, A., de Caestecker, M. (2017) Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury. Nephron. 137(4):268-272
Naylor, R.W., Han, H.I., Hukriede, N.A., Davidson, A.J. (2017) Wnt8a expands the pool of embryonic kidney progenitors in zebrafish. Developmental Biology. 425(2):130-141
Naylor, R.W., Skvarca, L.B., Thisse, C., Thisse, B., Hukriede, N.A., Davidson, A.J. (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nature communications. 7:12197
Skrypnyk, N.I., Sanker, S., Brilli-Skvarca, L., Novitskaya, T., Woods, C., Chiba, T., Patel, K., Goldberg, N.D., McDermott, L., Vinson, P.N., Calcutt, M.W., Huryn, D.M., Vernetti, L.A., Vogt, A., Hukriede, N., de Caestecker, M.P. (2016) Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury. American journal of physiology. Renal physiology. 310(8):F705-F71
Chiba, T., Skrypnyk, N.I., Skvarca, L.B., Penchev, R., Zhang, K.X., Rochon, E.R., Fall, J.L., Paueksakon, P., Yang, H., Alford, C.E., Roman, B.L., Zhang, M.Z., Harris, R., Hukriede, N.A., de Caestecker, M.P. (2016) Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI. Journal of the American Society of Nephrology : JASN. 27(2):495-508
Takata, K.I., Tomida, J., Reh, S., Swanhart, L.M., Takata, M., Hukriede, N.A., Wood, R.D. (2015) Conserved overlapping gene arrangement, restricted expression and biochemical activities of DNA polymerase ν; (POLN). The Journal of biological chemistry. 290(40):24278-93
Cirio, M.C., de Caestecker, M.P., Hukriede, N.A. (2015) Zebrafish Models of Kidney Damage and Repair. Current pathobiology reports. 3(2):163-170
Sanker, S., Cirio, M.C., Vollmer, L.L., Goldberg, N.D., McDermott, L.A., Hukriede, N.A., and Vogt, A. (2013) Development of High-Content Assays for Kidney Progenitor Cell Expansion in Transgenic Zebrafish. Journal of Biomolecular Screening. 18(10):1193-202
Cianciolo Cosentino, C., Skrypnyk, N.I., Brilli, L.L., Chiba, T., Novitskaya, T., Woods, C., West, J., Korotchenko, V.N., McDermott, L., Day, B.W., Davidson, A.J., Harris, R.C., de Caestecker, M.P., and Hukriede, N.A. (2013) Histone Deacetylase Inhibitor Enhances Recovery after AKI. Journal of the American Society of Nephrology : JASN. 24(6):943-53
Mo, D., Ihrke, G., Costa, S.A., Brilli, L., Labilloy, A., Halfter, W., Cosentino, C.C., Hukriede, N.A., and Weisz, O.A. (2012) Apical Targeting and Endocytosis of the Sialomucin Endolyn are Essential for Establishment of Zebrafish Pronephric Kidney Function. Journal of Cell Science. 125(22):5546-5554
Rbaibi, Y., Cui, S., Mo, D., Carattino, M., Rohatgi, R., Satlin, L.M., Szalinski, C.M., Swanhart, L.M., Fölsch, H., Hukriede, N.A., and Weisz, O.A. (2012) OCRL1 modulates cilia length in renal epithelial cells. Traffic (Copenhagen, Denmark). 13(9):1295-1305
Mitra, S., Lukianov, S., Ruiz, W.G., Cianciolo Cosentino, C., Sanker, S., Traub, L.M., Hukriede, N.A., and Apodaca, G. (2012) Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS One. 7(7):e41816
Vollmer, L.L., Jimenez, M., Camarco, D.P., Zhu, W., Daghestani, H.N., Balachandran, R., Reese, C.E., Lazo, J.S., Hukriede, N.A., Curran, D.P., Day, B.W., and Vogt, A. (2011) A simplified synthesis of novel dictyostatin analogs with in vitro activity against epothilone B resistant cells and antiangiogenic activity in zebrafish embryos. Molecular cancer therapeutics. 10(6):994-1006
Swanhart, L.M., Cosentino, C.C., Diep, C.Q., Davidson, A.J., de Caestecker, M., and Hukriede, N.A. (2011) Zebrafish kidney development: Basic science to translational research. Birth defects research. Part C, Embryo today : reviews. 93(2):141-156
Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Cowan, C.A., Hukriede, N.A., Handin, R.I., and Davidson, A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470(7332):95-100
Cianciolo Cosentino, C., Roman, B.L., Drummond, I.A., and Hukriede, N.A. (2010) Intravenous microinjections of zebrafish larvae to study acute kidney injury. Journal of visualized experiments : JoVE. (42)
Vogt, A., Codore, H., Day, B.W., Hukriede, N.A., and Tsang, M. (2010) Development of automated imaging and analysis for zebrafish chemical screens. Journal of visualized experiments : JoVE. (40)
de Groh, E.D., Swanhart, L.M., Cosentino, C.C., Jackson, R.L., Dai, W., Kitchens, C.A., Day, B.W., Smithgall, T.E., and Hukriede, N.A. (2010) Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population. Journal of the American Society of Nephrology : JASN. 21(5):794-802
Swanhart, L.M., Takahashi, N., Jackson, R.L., Gibson, G.A., Watkins, S.C., Dawid, I.B., and Hukriede, N.A. (2010) Characterization of an lhx1a transgenic reporter in zebrafish. The International journal of developmental biology. 54(4):731-736
Vogt, A., Cholewinski, A., Shen, X., Nelson, S.G., Lazo, J.S., Tsang, M., and Hukriede, N.A. (2009) Automated image-based phenotypic analysis in zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 238(3):656-663
Koide, K., Song, F., de Groh, E.D., Garner, A.L., Mitchell, V.D., Davidson, L.A., and Hukriede, N.A. (2008) Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos. Chembiochem : a European journal of chemical biology. 9(2):214-218
Bai, Q., Garver, J.A., Hukriede, N.A., and Burton, E.A. (2007) Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic acids research. 35(19):6501-6516
Pugacheva, E.M., Kwon, Y.W., Hukriede, N.A., Pack, S., Flanagan, P.T., Ahn, J.C., Park, J.A., Choi, K.S., Kim, K.W., Loukinov, D., Dawid, I.B., and Lobanenkov, V.V. (2006) Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization. Gene. 375:26-36
Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18473-18478
Kozlowski, D.J., Whitfield, T.T., Hukriede, N.A., Lam, W.K., and Weinberg, E.S. (2005) The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Developmental Biology. 277(1):27-41
Hukriede, N., Fisher, D., Epstein, J., Joly, L., Tellis, P., Zhou, Y., Barbazuk, B., Cox, K., Fenton-Noriega, L., Hersey, C., Miles, J., Sheng, X., Song, A., Waterman, R., Johnson, S.L., Dawid, I.B., Chevrette, M., Zon, L.I., McPherson, J., and Ekker, M. (2001) The LN54 radiation hybrid map of zebrafish expressed sequences. Genome research. 11(12):2127-2132
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. Genome research. 11(12):1979-1987
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. ZFIN Direct Data Submission.
Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proceedings of the National Academy of Sciences of the United States of America. 96(17):9745-9750

NON-ZEBRAFISH PUBLICATIONS
Gu, Y., Hukriede, N.A. and R.J. Fleming (1995) Induced in vivo expression of Serrate can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121, 855-865.

Hukriede, N.A. and R.J. Fleming (1997) Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. Genetics 145, 359-374.

Fleming, R.J., Gu, Y. and N.A. Hukriede (1997) Serrate mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124, 2973-2981.

Hukriede, N.A., Gu, Y. and R.J. Fleming (1997) A dominant-negative form of Serrate acts as a general antagonist of Notch Activation. Development 124, 3427-3437.

Kodjabachian, L., Karavanov, A.A., Hikasa, H., Hukriede, N.A., Aoki, T., Taira, M. and I.B. Dawid. (2001) A Study of Xlim1 function in Spemann’s organizer. Int. J. Dev. Biol.45, 209-218.

Chen, L., Segal, D., Hukriede, N.A., Podtelejnikov, A., Bayarsaihan, D., Kennison, J., Ogryzko, V., Dawid, I.B., Westphal H. (2002) Ssdp proteins interact with the LIM-domain binding protein Ldb1 to regulate development. Proc Natl Acad Sci U S A. 99(22):14320-5.

Hukriede, N.A., Tsang, T.E., Habas, R., Khoo, PL., Steiner, K., Weeks, D.L., Tam P.P.L. and I.B. Dawid (2003) Conserved Requirement of Lim1 Function for Cell Movements during Gastrulation. Developmental Cell 4, 83-94.