Person

Haramis, Anna-Pavlina

Person ID: ZDB-PERS-980618-11
Email: a.haramis@biology.leidenuniv.nl
URL: http://www.science.leidenuniv.nl/index.php/ibl/haramis
Affiliation: Haramis Lab
Address: Institute of Biology Leiden (IBL), Leiden University Sylvius Laboratory, Room 06.05.16b Sylviusweg 72, 2333 BE, Leiden The Netherlands
Country: Netherlands
Phone: +31 71 527 4782
Fax
ORCID ID

Biography and Research Interest

We are using the zebrafish as an experimental model system to elucidate the developmental roles of tumor suppressors and oncogenes and to dissect molecular mechanisms that when subverted contribute to cancer.We perform gain and loss of function experiments in embryos and characterize the phenotype of zebrafish mutants in these genes.
We are particularly interested in
• Analysis of cell polarity and energy metabolism during normal development and cancer
• Analysis of the developmental roles of the Polycomb group proteins
• Study of deubiquitination enzymes acting on the Wnt signaling pathway in zebrafish

Publications

Non-Zebrafish Publications

Haramis APG, Begthel H, van de Born M, van Es J, Jonkers S, Offerhaus GJA, and Clevers H (2004). De novo crypt formation and Juvenile Polyposis on BMP inhibition in mouse intestine. Science: 303, 1684-1686.
Zuniga A, Michos O, Spitz F, Haramis APG, Panman L, Galli A, Vintersten K, Klasen C, Mansfield W, Kuc S, Duboule D, Dono R, Zeller R (2004). Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18(13), 1553-1564.
van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis APG, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, and Hans Clevers (2002). The ²-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells. Cell: 111, 241-250.
Haramis APG*, Zuniga A*, McMahon AP, and Zeller R (1999). Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature: 401, 598-602.
Zeller R, Haramis AG, Zuniga A, Mc. Guigan C, Dono R, Davidson G, Chabanis S, and Gibson T (1999). Formin defines a novel family of morpho-regulatory genes and functions in establishment of the polarising region. Cell and Tissue Research: 296 (1), 85-93.
Haramis AG, Brown JM and Zeller R (1995). The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' Hox-D genes during limb pattern formation. Development: 121, 4237-4245.