ZFIN Person: Downes, Gerald

ZFIN ID: ZDB-PERS-980603-1

Downes, Gerald

Email:	gbdownes@bio.umass.edu
URL:	http://www.bio.umass.edu/biology/downes/index.htm
Affiliation:	Downes lab
Address:	University of Massachusetts - Amherst 427 Morrill Building 2 (611 North Pleasant Street) Amherst, MA 01003 USA
Country:	United States
Phone:	(215) 898-8386
Fax:	(215) 898-9871
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Kulick, D., Moon, E., Riffe, R.M., Teicher, G., Van Deursen, S., Berson, A., He, W., Aaron, G., Downes, G.B., Devoto, S., O'Neil, A. (2022) Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABA_A-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Component of Sporadic Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience. 13(24):3567-3577

Barnaby, W., Dorman Barclay, H.E., Nagarkar, A., Perkins, M., Teicher, G., Trapani, J.G., Downes, G.B. (2022) GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. 220(4):

Sant, K.E., Annunziato, K., Conlin, S., Teicher, G., Chen, P., Venezia, O., Downes, G.B., Park, Y., Timme-Laragy, A.R. (2021) Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 275:116644

Yildiz, O., Downes, G.B., Sagerström, C.G. (2019) Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain. Neural Development. 14:5

Monesson-Olson, B., McClain, J.J., Case, A.E., Dorman, H.E., Turkewitz, D.R., Steiner, A.B., Downes, G.B. (2018) Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. PLoS One. 13:e0196083

Mott, M., Luna, V.M., Park, J.Y., Downes, G.B., Epley, K., Ono, F. (2017) Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue. Scientific Reports. 7:1674

Johnson, K., Barragan, J., Bashiruddin, S., Smith, C.J., Tyrrell, C., Parsons, M.J., Doris, R., Kucenas, S., Downes, G.B., Velez, C.M., Schneider, C., Sakai, C., Pathak, N., Anderson, K., Stein, R., Devoto, S.H., Mumm, J.S., Barresi, M.J. (2016) Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia. 64(7):1170-89

Zannino, D.A., Downes, G.B., Sagerström, C.G. (2014) prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Developmental Biology. 390:247-60

de Soysa, T.Y., Ulrich, A., Friedrich, T., Pite, D., Compton, S.L., Ok, D., Bernardos, R.L., Downes, G.B., Hsieh, S., Stein, R., Lagdameo, M.C., Halvorsen, K., Kesich, L.R., and Barresi, M.J. (2012) Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. BMC Biology. 10(1):40

Friedrich, T., Lambert, A.M., Masino, M.A., and Downes, G.B. (2012) Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease. Disease models & mechanisms. 5(2):248-258

Khan, T.M., Benaich, N., Malone, C.F., Bernardos, R.L., Russell, A.R., Downes, G.B., Barresi, M.J., and Hutson, L.D. (2012) Vincristine and bortezomib cause axon outgrowth and behavioral defects in larval zebrafish. Journal of the peripheral nervous system : JPNS. 17(1):76-89

McKeown, K.A., Moreno, R., Hall, V.L., Ribera, A.B., and Downes, G.B. (2012) Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish. Developmental Biology. 362(2):162-171

Olson, B.D., Sgourdou, P., and Downes, G.B. (2010) Analysis of a zebrafish behavioral mutant reveals a dominant mutation in atp2a1/SERCA1. Genesis (New York, N.Y. : 2000). 48(6):354-361

McKeown, K.A., Downes, G.B., and Hutson, L.D. (2009) Modular laboratory exercises to analyze the development of zebrafish motor behavior. Zebrafish. 6(2):179-185

Downes, G.B., and Granato, M. (2006) Supraspinal input is dispensable to generate glycine-mediated locomotive behaviors in the zebrafish embryo. Journal of neurobiology. 66(5):437-451

Hirata, H., Saint-Amant, L., Downes, G.B., Cui, W.W., Zhou, W., Granato, M., and Kuwada, J.Y. (2005) Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor β-subunit. Proceedings of the National Academy of Sciences of the United States of America. 102(23):8345-8350

Downes, G.B., and Granato, M. (2004) Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental Biology. 270(1):232-245

Downes, G.B., Waterbury, J.A., and Granato, M. (2002) Rapid in vivo labeling of identified zebrafish neurons. Genesis (New York, N.Y. : 2000). 34(3):196-202

NON-ZEBRAFISH PUBLICATIONS