ZFIN ID: ZDB-PERS-980202-11
Parichy, David M.
Email: dparichy@virginia.edu
URL: http://faculty.washington.edu/dparichy/
Affiliation: Parichy Lab
Address: Pratt-Ivy Foundation Distinguished Professor of Morphogenesis Department of Biology University of Virginia Charlottesville VA 22904
Country: United States

• evolution and development of pigment pattern in zebrafish and other fishes
• biology of post-embryonic stem cells derived from the neural crest
• dwarfism syndromes and bone development
• developmental genetics of metamorphosis
• behavioral and ecological significance of pigment pattern variation

Aman, A.J., Parichy, D.M. (2024) Anatomy, development and regeneration of zebrafish elasmoid scales. Developmental Biology. 510:1-7
Aman, A.J., Saunders, L.M., Carr, A.A., Srivatasan, S., Eberhard, C., Carrington, B., Watkins-Chow, D., Pavan, W.J., Trapnell, C., Parichy, D.M. (2023) Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin. eLIFE. 12:
Lalonde, R.L., Kemmler, C.L., Riemslagh, F.W., Aman, A.J., Kresoja-Rakic, J., Moran, H.R., Nieuwenhuize, S., Parichy, D.M., Burger, A., Mosimann, C. (2022) Heterogeneity and genomic loci of ubiquitous transgenic Cre reporter lines in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(10):1754-1773
McCluskey, B.M., Liang, Y., Lewis, V.M., Patterson, L.B., Parichy, D.M. (2021) Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects. Biology Open. 10(9):
Huang, D., Lewis, V.M., Foster, T.N., Toomey, M.B., Corbo, J.C., Parichy, D.M. (2021) Development and genetics of red coloration in the zebrafish relative Danio albolineatus. eLIFE. 10:
Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M. (2021) Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development. Developmental Biology. 477:205-218
Eom, D.S., Patterson, L.B., Bostic, R.R., Parichy, D.M. (2021) Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Developmental Biology. 476:314-327
McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
Gur, D., Bain, E.J., Johnson, K.R., Aman, A.J., Pasoili, H.A., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Lippincott-Schwartz, J., Parichy, D.M. (2020) In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning. Nature communications. 11:6391
Volkov, L.I., Kim-Han, J.S., Saunders, L.M., Poria, D., Hughes, A.E.O., Kefalov, V.J., Parichy, D.M., Corbo, J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15262-15269
Patterson, L.B., Parichy, D.M. (2019) Zebrafish Pigment Pattern Formation: Insights into the Development and Evolution of Adult Form. Annual review of genetics. 53:505-530
Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
Salis, P., Lorin, T., Lewis, V., Rey, C., Marcionetti, A., Escande, M.L., Roux, N., Besseau, L., Salamin, N., Sémon, M., Parichy, D., Volff, J.N., Laudet, V. (2019) Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish. Pigment cell & melanoma research. 32(3):391-402
Spiewak, J.E., Bain, E.J., Liu, J., Kou, K., Sturiale, S.L., Patterson, L.B., Diba, P., Eisen, J.S., Braasch, I., Ganz, J., Parichy, D.M. (2018) Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLoS Genetics. 14:e1007538
Aman, A.J., Fulbright, A.N., Parichy, D.M. (2018) Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development. eLIFE. 7:
Patterson, L.B., Parichy, D.M. (2018) Melanophores Tune Out the Noise to Make Stripes. Developmental Cell. 45:544-545
Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) MicroCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ System. Zebrafish. 15(1):77-78
Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) microCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system. eLIFE. 6
Eom, D.S., Parichy, D.M. (2017) A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science (New York, N.Y.). 355(6331):1317-1320
McMenamin, S.K., Chandless, M.N., Parichy, D.M. (2016) Working with zebrafish at postembryonic stages. Methods in cell biology. 134:587-607
Eom, D.S., Bain, E.J., Patterson, L.B., Grout, M.E., Parichy, D.M. (2015) Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLIFE. 4
Parichy, D.M. (2015) Advancing biology through a deeper understanding of zebrafish ecology and evolution. eLIFE. 4
McMenamin, S.K., Bain, E.J., McCann, A.E., Patterson, L.B., Eom, D.S., Waller, Z.P., Hamill, J.C., Kuhlman, J.A., Eisen, J.S., Parichy, D.M. (2014) Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science (New York, N.Y.). 345(6202):1358-61
Inoue, S., Kondo, S., Parichy, D.M., Watanabe, M. (2014) Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. Pigment cell & melanoma research. 27:190-200
Hamada, H., Watanabe, M., Lau, H.E., Nishida, T., Hasegawa, T., Parichy, D.M., and Kondo, S. (2014) Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development (Cambridge, England). 141(2):318-324
Patterson, L.B., and Parichy, D.M. (2013) Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLoS Genetics. 9(5):e1003561
McMenamin, S.K., Minchin, J.E., Gordon, T.N., Rawls, J.F., and Parichy, D.M. (2013) Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizzini. Endocrinology. 154(4):1476-87
Eom, D.S., Inoue, S., Patterson, L.B., Gordon, T.N., Slingwine, R., Kondo, S., Watanabe, M., and Parichy, D.M. (2012) Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11. PLoS Genetics. 8(8):e1002899
Roeselers, G., Mittge, E.K., Stephens, W.Z., Parichy, D.M., Cavanaugh, C.M., Guillemin, K., and Rawls, J.F. (2011) Evidence for a core gut microbiota in the zebrafish. The ISME Journal. 5(10):1595-608
Budi, E.H., Patterson, L.B., and Parichy, D.M. (2011) Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genetics. 7(5):e1002044
Elizondo, M.R., Budi, E.H., and Parichy, D.M. (2010) trpm7 Regulation of in Vivo Cation Homeostasis and Kidney Function Involves Stanniocalcin 1 and fgf23. Endocrinology. 151(12):5700-5709
Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M. (2010) Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Developmental Biology. 346(2):296-309
Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W. (2010) Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344(1):107-118
Christiansen, H.E., Lang, M.R., Pace, J.M., and Parichy, D.M. (2009) Critical early roles for col27a1a and col27a1b in zebrafish notochord morphogenesis, vertebral mineralization and post-embryonic axial growth. PLoS One. 4(12):e8481
Parichy, D.M., Elizondo, M.R., Mills, M.G., Gordon, T.N., and Engeszer, R.E. (2009) Normal table of postembryonic zebrafish development: Staging by externally visible anatomy of the living fish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(12):2975-3015
Lang, M.R., Patterson, L.B., Gordon, T.N., Johnson, S.L., and Parichy, D.M. (2009) Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genetics. 5(11):e1000744
Hultman, K.A., Budi, E.H., Teasley, D.C., Gottlieb, A.Y., Parichy, D.M., and Johnson, S.L. (2009) Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genetics. 5(7):e1000544
Ekker, S.C., Parichy, D.M., and Cheng, K.C. (2008) Research implications of pigment biology in zebrafish. Zebrafish. 5(4):233-235
Budi, E.H., Patterson, L.B., and Parichy, D.M. (2008) Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development (Cambridge, England). 135(15):2603-2614
Engeszer, R.E., Wang, G., Ryan, M.J., and Parichy, D.M. (2008) Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proceedings of the National Academy of Sciences of the United States of America. 105(3):929-933
Engeszer, R.E., Barbiano, L.A., Ryan, M.J., and Parichy, D.M. (2007) Timing and plasticity of shoaling behaviour in the zebrafish, Danio rerio. Animal behaviour. 74(5):1269-1275
Parichy, D.M. (2007) Homology and the evolution of novelty during Danio adult pigment pattern development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):578-590
Engeszer, R.E., Patterson, L.B., Rao, A.A., and Parichy, D.M. (2007) Zebrafish in The Wild: A Review of Natural History And New Notes from The Field. Zebrafish. 4(1):21-40
Mills, M.G., Nuckels, R.J., and Parichy, D.M. (2007) Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development (Cambridge, England). 134(6):1081-1090
Parichy, D.M. (2006) Evolution of danio pigment pattern development. Heredity. 97(3):200-210
Elizondo, M.R., Arduini, B.L., Paulsen, J., MacDonald, E.L., Sabel, J.L., Henion, P.D., Cornell, R.A., Parichy, D.M. (2005) Defective Skeletogenesis with Kidney Stone Formation in Dwarf Zebrafish Mutant for trpm7. Current biology : CB. 15(7):667-671
Quigley, I.K., Manuel, J.L., Roberts, R.A., Nuckels, R.J., Herrington, E.R., MacDonald, E.L., and Parichy, D.M. (2005) Evolutionary diversification of pigment pattern in Danio fishes: differential fms dependence and stripe loss in D. albolineatus. Development (Cambridge, England). 132(1):89-104
Quigley, I.K., Turner, J.M., Nuckels, R.J., Manuel, J.L., Budi, E.H., MacDonald, E.L., and Parichy, D.M. (2004) Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development (Cambridge, England). 131(24):6053-6069
Engeszer, R.E., Ryan, M.J., and Parichy, D.M. (2004) Learned social preference in zebrafish. Current biology : CB. 14(10):881-884
Parichy, D.M. (2003) Pigment patterns: fish in stripes and spots. Current biology : CB. 13(24):R947-950
Parichy, D.M. and Turner, J.M. (2003) Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis. Developmental Biology. 256(2):242-257
Parichy, D.M., Turner, J.M., and Parker, N.B. (2003) Essential role for puma in development of postembryonic neural crest-derived cell lineages in zebrafish. Developmental Biology. 256(2):221-241
Parichy, D.M. and Turner, J.M. (2003) Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development. Development (Cambridge, England). 130(5):817-833
Parichy, D.M. and Johnson, S.L. (2001) Zebrafish hybrids suggest genetic mechanisms for pigment pattern diversification in Danio. Development genes and evolution. 211(7):319-328
Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306
Parichy, D.M., Ransom, D.G., Paw, B., Zon, L.I., and Johnson, S.L. (2000) An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development (Cambridge, England). 127(14):3031-3044
Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436

Voss SR, Smith JJ, Gardiner D, Parichy DM. 2001. Conserved vertebrate chromosome segments in the large salamander genome. Genetics 158:735–746.

Parichy DM. 2001. “Pigment patterns of ectothermic vertebrates: heterochronic vs. non-heterochronic models for pigment pattern evolution.” In: Beyond Heterochrony (M. Zelditch, Ed.). Wiley.

Parichy, D. M. 2000. Homology and evolutionary novelty in the deployment of extracellular matrix molecules during pigment pattern formation in the salamanders Taricha torosa and T. rivularis (Salamandridae). J. Exp. Zool (Mol. Dev. Evol.) 288, in press.

Parichy, D. M. and Johnson, S. L. 1999. Evolutionary genetics of Danio pigment pattern development. Dev. Biol. 210:192.

Parichy, D. M., Rawls, J. F., Pratt, S. J., Whitfield, T. T., and Johnson, S. L. 1999. Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not required for hematopoiesis or primordial germ cell development. Development 126:3425-3426.

Parichy, D. M., Stigson, M. and Voss, S. R. 1999. Genetic analysis of Steel and the PG-M/versican-encoding gene AxPG as candidate genes for the white (d) pigmentation mutant in the salamander Ambystoma mexicanum. Development, Genes, and Evolution 209:349–356.

Parichy, D. M. 1998. Experimental analysis of character coupling across a complex life cycle: pigment pattern metamorphosis in the tiger salamander, Ambystoma tigrinum tigrinum. Journal of Morphology 237:53–67.

Reedy, M. V., Parichy, D. M., Erickson, C. A., Mason, K. and Frost-Mason, S. K. 1998. “Regulation of melanoblast migration and differentiation,” Chapter 4, in: The Pigmentary System and its Disorders (Nordland, J. J., Boissy, R. E., Hearing, V. J., King, R. A. and Ortonne, J. P., Eds.). Oxford University Press.

Parichy, D. M. 1996. Pigment patterns of larval salamanders (Ambystomatidae, Salamandridae): the role of the lateral line sensory system and the evolution of pattern-forming mechanisms. Developmental Biology 175:265–282.

Parichy, D. M. 1996. When neural crest and placodes collide: interactions between melanophores and the lateral lines that generate stripes in the salamander Ambystoma tigrinum tigrinum (Ambystomatidae). Developmental Biology 175:283–300.

Parichy, D. M. 1996. Salamander pigment patterns: how can they be used to study developmental mechanisms and their evolutionary transformation? International Journal of Developmental Biology 40:871–884.

Parichy, D. M., and Kaplan, R. H. 1995. Maternal investment and developmental plasticity: functional consequences for locomotor performance of hatchling frog larvae. Functional Ecology 9:606–617.

Parichy, D. M., and Kaplan, R. H. 1992. Maternal effects on offspring growth and development depend on environmental quality in the frog, Bombina orientalis. Oecologia 91:579–586.

Parichy, D. M., and Kaplan, R. H. 1992. Developmental consequences of tail injury on the oriental fire-bellied toad, Bombina orientalis. Copeia 1992:129–137.

Parichy, D. M., Shaffer, H. B. and Mangel, M. 1992. Heterochrony as a unifying theme in evolution and development. Evolution 46:1252–1254. (Book review.)