ZFIN Person: Parichy, David M.

ZFIN ID: ZDB-PERS-980202-11

ZFIN ID: ZDB-PERS-980202-11

Parichy, David M.

Email:	dparichy@virginia.edu
URL:	http://faculty.washington.edu/dparichy/
Affiliation:	Parichy Lab
Address:	Pratt-Ivy Foundation Distinguished Professor of Morphogenesis Department of Biology University of Virginia Charlottesville VA 22904
Country:	United States
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

• evolution and development of pigment pattern in zebrafish and other fishes
• biology of post-embryonic stem cells derived from the neural crest
• dwarfism syndromes and bone development
• developmental genetics of metamorphosis
• behavioral and ecological significance of pigment pattern variation

PUBLICATIONS

Gur, D., Bain, E.J., Johnson, K.R., Aman, A.J., Pasoili, H.A., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Lippincott-Schwartz, J., Parichy, D.M. (2020) In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning. Nature communications. 11:6391

Volkov, L.I., Kim-Han, J.S., Saunders, L.M., Poria, D., Hughes, A.E.O., Kefalov, V.J., Parichy, D.M., Corbo, J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15262-15269

Patterson, L.B., Parichy, D.M. (2019) Zebrafish Pigment Pattern Formation: Insights into the Development and Evolution of Adult Form. Annual review of genetics. 53:505-530

Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:

Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811

Salis, P., Lorin, T., Lewis, V., Rey, C., Marcionetti, A., Escande, M.L., Roux, N., Besseau, L., Salamin, N., Sémon, M., Parichy, D., Volff, J.N., Laudet, V. (2019) Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish. Pigment cell & melanoma research. 32(3):391-402

Spiewak, J.E., Bain, E.J., Liu, J., Kou, K., Sturiale, S.L., Patterson, L.B., Diba, P., Eisen, J.S., Braasch, I., Ganz, J., Parichy, D.M. (2018) Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLoS Genetics. 14:e1007538

Aman, A.J., Fulbright, A.N., Parichy, D.M. (2018) Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development. eLIFE. 7:

Patterson, L.B., Parichy, D.M. (2018) Melanophores Tune Out the Noise to Make Stripes. Developmental Cell. 45:544-545

Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) MicroCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ System. Zebrafish. 15(1):77-78

Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) microCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system. eLIFE. 6

Eom, D.S., Parichy, D.M. (2017) A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science (New York, N.Y.). 355(6331):1317-1320

McMenamin, S.K., Chandless, M.N., Parichy, D.M. (2016) Working with zebrafish at postembryonic stages. Methods in cell biology. 134:587-607

Eom, D.S., Bain, E.J., Patterson, L.B., Grout, M.E., Parichy, D.M. (2015) Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLIFE. 4

Parichy, D.M. (2015) Advancing biology through a deeper understanding of zebrafish ecology and evolution. eLIFE. 4

McMenamin, S.K., Bain, E.J., McCann, A.E., Patterson, L.B., Eom, D.S., Waller, Z.P., Hamill, J.C., Kuhlman, J.A., Eisen, J.S., Parichy, D.M. (2014) Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science (New York, N.Y.). 345(6202):1358-61

Inoue, S., Kondo, S., Parichy, D.M., Watanabe, M. (2014) Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. Pigment cell & melanoma research. 27:190-200

Hamada, H., Watanabe, M., Lau, H.E., Nishida, T., Hasegawa, T., Parichy, D.M., and Kondo, S. (2014) Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development (Cambridge, England). 141(2):318-324

Patterson, L.B., and Parichy, D.M. (2013) Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLoS Genetics. 9(5):e1003561

McMenamin, S.K., Minchin, J.E., Gordon, T.N., Rawls, J.F., and Parichy, D.M. (2013) Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizzini. Endocrinology. 154(4):1476-87

Eom, D.S., Inoue, S., Patterson, L.B., Gordon, T.N., Slingwine, R., Kondo, S., Watanabe, M., and Parichy, D.M. (2012) Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11. PLoS Genetics. 8(8):e1002899

Roeselers, G., Mittge, E.K., Stephens, W.Z., Parichy, D.M., Cavanaugh, C.M., Guillemin, K., and Rawls, J.F. (2011) Evidence for a core gut microbiota in the zebrafish. The ISME Journal. 5(10):1595-608

Budi, E.H., Patterson, L.B., and Parichy, D.M. (2011) Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genetics. 7(5):e1002044

Elizondo, M.R., Budi, E.H., and Parichy, D.M. (2010) trpm7 Regulation of in Vivo Cation Homeostasis and Kidney Function Involves Stanniocalcin 1 and fgf23. Endocrinology. 151(12):5700-5709

Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M. (2010) Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Developmental Biology. 346(2):296-309

Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W. (2010) Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344(1):107-118

Christiansen, H.E., Lang, M.R., Pace, J.M., and Parichy, D.M. (2009) Critical early roles for col27a1a and col27a1b in zebrafish notochord morphogenesis, vertebral mineralization and post-embryonic axial growth. PLoS One. 4(12):e8481

Parichy, D.M., Elizondo, M.R., Mills, M.G., Gordon, T.N., and Engeszer, R.E. (2009) Normal table of postembryonic zebrafish development: Staging by externally visible anatomy of the living fish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(12):2975-3015

Lang, M.R., Patterson, L.B., Gordon, T.N., Johnson, S.L., and Parichy, D.M. (2009) Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genetics. 5(11):e1000744

Hultman, K.A., Budi, E.H., Teasley, D.C., Gottlieb, A.Y., Parichy, D.M., and Johnson, S.L. (2009) Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genetics. 5(7):e1000544

Ekker, S.C., Parichy, D.M., and Cheng, K.C. (2008) Research implications of pigment biology in zebrafish. Zebrafish. 5(4):233-235

Budi, E.H., Patterson, L.B., and Parichy, D.M. (2008) Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development (Cambridge, England). 135(15):2603-2614

Engeszer, R.E., Wang, G., Ryan, M.J., and Parichy, D.M. (2008) Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proceedings of the National Academy of Sciences of the United States of America. 105(3):929-933

Engeszer, R.E., Barbiano, L.A., Ryan, M.J., and Parichy, D.M. (2007) Timing and plasticity of shoaling behaviour in the zebrafish, Danio rerio. Animal behaviour. 74(5):1269-1275

Parichy, D.M. (2007) Homology and the evolution of novelty during Danio adult pigment pattern development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):578-590

Mills, M.G., Nuckels, R.J., and Parichy, D.M. (2007) Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development (Cambridge, England). 134(6):1081-1090

Engeszer, R.E., Patterson, L.B., Rao, A.A., and Parichy, D.M. (2007) Zebrafish in The Wild: A Review of Natural History And New Notes from The Field. Zebrafish. 4(1):21-40

Parichy, D.M. (2006) Evolution of danio pigment pattern development. Heredity. 97(3):200-210

Elizondo, M.R., Arduini, B.L., Paulsen, J., MacDonald, E.L., Sabel, J.L., Henion, P.D., Cornell, R.A., Parichy, D.M. (2005) Defective Skeletogenesis with Kidney Stone Formation in Dwarf Zebrafish Mutant for trpm7. Current biology : CB. 15(7):667-671

Quigley, I.K., Manuel, J.L., Roberts, R.A., Nuckels, R.J., Herrington, E.R., MacDonald, E.L., and Parichy, D.M. (2005) Evolutionary diversification of pigment pattern in Danio fishes: differential fms dependence and stripe loss in D. albolineatus. Development (Cambridge, England). 132(1):89-104

Quigley, I.K., Turner, J.M., Nuckels, R.J., Manuel, J.L., Budi, E.H., MacDonald, E.L., and Parichy, D.M. (2004) Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development (Cambridge, England). 131(24):6053-6069

Engeszer, R.E., Ryan, M.J., and Parichy, D.M. (2004) Learned social preference in zebrafish. Current biology : CB. 14(10):881-884

Parichy, D.M. (2003) Pigment patterns: fish in stripes and spots. Current biology : CB. 13(24):R947-950

Parichy, D.M. and Turner, J.M. (2003) Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis. Developmental Biology. 256(2):242-257

Parichy, D.M., Turner, J.M., and Parker, N.B. (2003) Essential role for puma in development of postembryonic neural crest-derived cell lineages in zebrafish. Developmental Biology. 256(2):221-241

Parichy, D.M. and Turner, J.M. (2003) Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development. Development (Cambridge, England). 130(5):817-833

Parichy, D.M. and Johnson, S.L. (2001) Zebrafish hybrids suggest genetic mechanisms for pigment pattern diversification in Danio. Development genes and evolution. 211(7):319-328

Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306

Parichy, D.M., Ransom, D.G., Paw, B., Zon, L.I., and Johnson, S.L. (2000) An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development (Cambridge, England). 127(14):3031-3044

Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436

NON-ZEBRAFISH PUBLICATIONS
Voss SR, Smith JJ, Gardiner D, Parichy DM. 2001. Conserved vertebrate chromosome segments in the large salamander genome. Genetics 158:735–746.

Parichy DM. 2001. “Pigment patterns of ectothermic vertebrates: heterochronic vs. non-heterochronic models for pigment pattern evolution.” In: Beyond Heterochrony (M. Zelditch, Ed.). Wiley.

Parichy, D. M. 2000. Homology and evolutionary novelty in the deployment of extracellular matrix molecules during pigment pattern formation in the salamanders Taricha torosa and T. rivularis (Salamandridae). J. Exp. Zool (Mol. Dev. Evol.) 288, in press.

Parichy, D. M. and Johnson, S. L. 1999. Evolutionary genetics of Danio pigment pattern development. Dev. Biol. 210:192.

Parichy, D. M., Rawls, J. F., Pratt, S. J., Whitfield, T. T., and Johnson, S. L. 1999. Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not required for hematopoiesis or primordial germ cell development. Development 126:3425-3426.

Parichy, D. M., Stigson, M. and Voss, S. R. 1999. Genetic analysis of Steel and the PG-M/versican-encoding gene AxPG as candidate genes for the white (d) pigmentation mutant in the salamander Ambystoma mexicanum. Development, Genes, and Evolution 209:349–356.

Parichy, D. M. 1998. Experimental analysis of character coupling across a complex life cycle: pigment pattern metamorphosis in the tiger salamander, Ambystoma tigrinum tigrinum. Journal of Morphology 237:53–67.

Reedy, M. V., Parichy, D. M., Erickson, C. A., Mason, K. and Frost-Mason, S. K. 1998. “Regulation of melanoblast migration and differentiation,” Chapter 4, in: The Pigmentary System and its Disorders (Nordland, J. J., Boissy, R. E., Hearing, V. J., King, R. A. and Ortonne, J. P., Eds.). Oxford University Press.

Parichy, D. M. 1996. Pigment patterns of larval salamanders (Ambystomatidae, Salamandridae): the role of the lateral line sensory system and the evolution of pattern-forming mechanisms. Developmental Biology 175:265–282.

Parichy, D. M. 1996. When neural crest and placodes collide: interactions between melanophores and the lateral lines that generate stripes in the salamander Ambystoma tigrinum tigrinum (Ambystomatidae). Developmental Biology 175:283–300.

Parichy, D. M. 1996. Salamander pigment patterns: how can they be used to study developmental mechanisms and their evolutionary transformation? International Journal of Developmental Biology 40:871–884.

Parichy, D. M., and Kaplan, R. H. 1995. Maternal investment and developmental plasticity: functional consequences for locomotor performance of hatchling frog larvae. Functional Ecology 9:606–617.

Parichy, D. M., and Kaplan, R. H. 1992. Maternal effects on offspring growth and development depend on environmental quality in the frog, Bombina orientalis. Oecologia 91:579–586.

Parichy, D. M., and Kaplan, R. H. 1992. Developmental consequences of tail injury on the oriental fire-bellied toad, Bombina orientalis. Copeia 1992:129–137.

Parichy, D. M., Shaffer, H. B. and Mangel, M. 1992. Heterochrony as a unifying theme in evolution and development. Evolution 46:1252–1254. (Book review.)