ZFIN ID: ZDB-PERS-971001-6
Trudeau, V.L.
Email: vance.trudeau@uottawa.ca
URL: https://www.teamendo.ca/
Address: University Research Chair in Neuroendocrinology Dept. of Biology University of Ottawa Ottawa, Ontario
Country: Canada
Phone: 1-613-562-5800 x6165
Fax: 1-613-562-5486
ORCID ID: 0000-0002-0845-9444

Vance L. Trudeau was born and raised in Dartmouth, Nova Scotia, Kjipuktuk, Mi’kma’ki, the unceded territory of the Mi’kmaq People.

Trudeau received his BSc and MSc from McGill University and PhD at the University of Alberta under the supervision of Richard E. Peter. After post-doctoral training in Canada with Leo Renaud and in France with Dominique Poulain and Dionysia Theodosis, he took up his first academic position at the University of Aberdeen (Scotland). He later joined the Department of Biology, University of Ottawa in 1998.

Trudeau holds the University of Ottawa Research Chair in Neuroendocrinology (2011-2026) and leads a team of dynamic trainees with wide interests and talents. Worldwide collaborations are also fundamental to the advancement of our research and are deeply appreciated. His group's research is directed towards understanding how the vertebrate brain regulates anterior pituitary hormones that control sexual development and reproduction using fish and frog models. Applications of this basic research include spawning induction methods for endangered amphibians, among others. The team also studies the effects of sex steroids and pollutants (pharmaceuticals, pesticides, petroleum products) on development and reproduction in fish and frogs. This concept is called endocrine disruption. Research conducted by TEAMENDO.CA has implications for environmental and human health because many of these hormonal systems are conserved across species. This means that what is discovered in one species, has major implications in other vertebrate, including humans.

Trudeau was founding Vice-President of the North American Society for Comparative Endocrinology (http://nasce-snaec.com/) and is the current President of the International Society for Fish Endocrinology (https://www.isfendo.com/)

Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
Lu, C., Peng, D., Erandani, W.C.K.U., Mitchell, K., Martyniuk, C.J., Trudeau, V.L. (2023) Simultaneous extraction and detection of peptides, steroids, and proteins in small tissue samples. Frontiers in endocrinology. 14:12669851266985
Shaw, K., Therrien, M., Lu, C., Liu, X., Trudeau, V.L. (2023) Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish. Frontiers in endocrinology. 14:12251991225199
Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
Nozari, A., Gagné, R., Lu, C., Yauk, C., Trudeau, V.L. (2022) Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish. Frontiers in endocrinology. 13:847322
Nozari, A., Do, S., Trudeau, V.L. (2021) Applications of the SR4G Transgenic Zebrafish Line for Biomonitoring of Stress-Disrupting Compounds: A Proof-of-Concept Study. Frontiers in endocrinology. 12:727777
Mitchell, K., Mikwar, M., Da Fonte, D., Lu, C., Tao, B., Peng, D., Udeesha Erandani, W.K.C., Hu, W., Trudeau, V.L. (2020) Secretoneurin is a secretogranin-2 derived hormonal peptide in vertebrate neuroendocrine systems. General and comparative endocrinology. 299:113588
Somoza, G.M., Mechaly, A.S., Trudeau, V.L. (2020) Kisspeptin and GnRH interactions in the reproductive brain of teleosts. General and comparative endocrinology. 298:113568
Mitchell, K., Zhang, W.S., Lu, C., Tao, B., Chen, L., Hu, W., Trudeau, V.L. (2020) Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(23):12772-12783
Feng, K., Cui, X., Song, Y., Tao, B., Chen, J., Wang, J., Liu, S., Sun, Y., Zhu, Z., Trudeau, V.L., Hu, W. (2019) Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish. Endocrinology. 161(1):
Vera-Chang, M.N., St-Jacques, A.D., Lu, C., Moon, T.W., Trudeau, V.L. (2019) Fluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult Zebrafish Danio rerio. Frontiers in neuroscience. 13:1015
Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Cortisol disruption and transgenerational alterations in the expression of stress-related genes in zebrafish larvae following fluoxetine exposure. Toxicology and applied pharmacology. 382:114742
Vera-Chang, M.N., Moon, T.W., Trudeau, V.L. (2019) Ancestral fluoxetine exposure sensitizes zebrafish to venlafaxine-induced reductions in cortisol and spawning. Endocrinology. 160(9):2137-2142
Martinez, R., Vera-Chang, M.N., Haddad, M., Zon, J., Navarro-Martin, L., Trudeau, V.L., Mennigen, J.A. (2019) Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission. PLoS One. 14:e0212577
Vera-Chang, M.N., St-Jacques, A.D., Gagné, R., Martyniuk, C.J., Yauk, C.L., Moon, T.W., Trudeau, V.L. (2018) Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio. Proceedings of the National Academy of Sciences of the United States of America. 115(52):E12435-E12442
Tao, B., Hu, H., Mitchell, K., Chen, J., Jia, H., Zhu, Z., Trudeau, V.L., Hu, W. (2018) Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of molecular cell biology. 10(5):388-401
Trudeau, V.L. (2018) Facing the Challenges of Neuropeptide Gene Knockouts: Why Do They Not Inhibit Reproduction in Adult Teleost Fish?. Frontiers in neuroscience. 12:302
Xia, H., Zhong, C., Wu, X., Chen, J., Tao, B., Xia, X., Shi, M., Zhu, Z., Trudeau, V.L., Hu, W. (2017) Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.. Genetics. 208(2):729-743
Song, Y., Tao, B., Chen, J., Jia, S., Zhu, Z., Trudeau, V.L., Hu, W. (2017) GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish. Endocrinology. 158(4):874-886
Cameron, B.E., Craig, P.M., Trudeau, V.L. (2016) Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals. Environmental toxicology and chemistry. 35:788-93
Trudeau, V.L. (2015) Kiss and tell: Deletion of kisspeptins and receptors reveal surprising results see article in Endocrinology February 2015;156: 589-599. Endocrinology. 156:769-71
Craig, P.M., Trudeau, V.L., Moon, T.W. (2014) Profiling Hepatic microRNAs in Zebrafish: Fluoxetine Exposure Mimics a Fasting Response That Targets AMP-Activated Protein Kinase (AMPK). PLoS One. 9:e95351
Massarsky, A., Strek, L., Craig, P.M., Eisa-Beygi, S., Trudeau, V.L., and Moon, T.W. (2014) Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults. The Science of the total environment. 478:133-140
McMillan, S.C., Xu, Z.T., Zhang, J., Teh, C., Korzh, V., Trudeau, V.L., and Akimenko, M.A. (2013) Regeneration of breeding tubercles on zebrafish pectoral fins requires androgens and two waves of revascularization. Development (Cambridge, England). 140(21):4323-4334
Massarsky, A., Dupuis, L., Taylor, J., Eisa-Beygi, S., Strek, L., Trudeau, V.L., and Moon, T.W. (2013) Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Chemosphere. 92(1):59-66
Zhang, D., Xi, Y., Coccimiglio, M.L., Mennigen, J.A., Jonz, M., Ekker, M., and Trudeau, V.L. (2012) Functional prediction and physiological characterization of a novel short trans-membrane protein 1 (Stmp1) as a subunit of mitochondrial respiratory complexes. Physiological Genomics. 44(23):1133-1140
Martyniuk, C.J., Gerrie, E.R., Popesku, J.T., Ekker, M., and Trudeau, V.L. (2007) Microarray analysis in the zebrafish (Danio rerio) liver and telencephalon after exposure to low concentration of 17alpha-ethinylestradiol. Aquatic toxicology (Amsterdam, Netherlands). 84(1):38-49
Martyniuk, C.J., Awad, R., Hurley, R., Finger, T.E., and Trudeau, V.L. (2007) Glutamic acid decarboxylase 65, 67, and GABA-transaminase mRNA expression and total enzyme activity in the goldfish (Carassius auratus) brain. Brain research. 1147(1):154-166
Coverdale, L.E., Martyniuk, C.J., Trudeau, V.L., and Martin, C.C. (2004) Differential expression of the methyl-cytosine binding protein 2 gene in embryonic and adult brain of zebrafish. Brain research. Developmental brain research. 153(2):281-287
Bosma, P.T., Blazquez, M., Collins, M.A., Bishop, J.D., Drouin, G., Priede, I.G., Docherty, K., and Trudeau, V.L. (1999) Multiplicity of glutamic acid decarboxylases (GAD) in vertebrates: molecular phylogeny and evidence for a new GAD paralog. Mol. Biol. Evol.. 16(3):397-404
Zou, J.J., Trudeau, V.L., Cui, Z., Brechin, J., Mackenzie, K., Zhu, Z., Houlihan, D.F., and Peter, R.E. (1997) Estradiol stimulates growth hormone production in female goldfish. General and comparative endocrinology. 106(1):102-112

Scaia, M. F., Trudeau, V. L., Somoza, G. M., & Pandolfi, M. (2023). Fighting cichlids: An integrated multimodal analysis to understand female and male aggression in Cichlasoma dimerus. Hormones and behavior, 148, 105301. https://doi.org/10.1016/j.yhbeh.2022.105301

Carriquiriborde, P., Fernandino, J. I., López, C. G., Benito, E. S., Gutierrez-Villagomez, J. M., Cristos, D., Trudeau, V. L., & Somoza, G. M. (2023). Atrazine alters early sexual development of the South American silverside, Odontesthes bonariensis. Aquatic toxicology (Amsterdam, Netherlands), 254, 106366. https://doi.org/10.1016/j.aquatox.2022.106366

Mennigen, J. A., Ramachandran, D., Shaw, K., Chaube, R., Joy, K. P., & Trudeau, V. L. (2022). Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes. Frontiers in endocrinology, 13, 1005863. https://doi.org/10.3389/fendo.2022.1005863

Zhang, W. S., Farmer, E. J., Muhanzi, D., & Trudeau, V. L. (2022). Petroleum-derived naphthenic acids disrupt hormone-dependent sexual behaviours in male Western clawed frogs. Conservation physiology, 10(1), coac030. https://doi.org/10.1093/conphys/coac030

Zohar, Y., Zmora, N., Trudeau, V. L., Muñoz-Cueto, J. A., & Golan, M. (2022). A half century of fish gonadotropin-releasing hormones: Breaking paradigms. Journal of neuroendocrinology, 34(5), e13069. https://doi.org/10.1111/jne.13069

Trudeau V. L. (2022). Neuroendocrine Control of Reproduction in Teleost Fish: Concepts and Controversies. Annual review of animal biosciences, 10, 107–130. https://doi.org/10.1146/annurev-animal-020420-042015

Robaire, B., Delbes, G., Head, J. A., Marlatt, V. L., Martyniuk, C. J., Reynaud, S., Trudeau, V. L., & Mennigen, J. A. (2022). A cross-species comparative approach to assessing multi- and transgenerational effects of endocrine disrupting chemicals. Environmental research, 204(Pt B), 112063. https://doi.org/10.1016/j.envres.2021.112063