ZFIN Person: Kawakami, Atsushi

ZFIN ID: ZDB-PERS-970313-16

ZFIN ID: ZDB-PERS-970313-16

Kawakami, Atsushi

Email:	atkawaka@bio.titech.ac.jp
URL:	http://www.kawakami.bio.titech.ac.jp/index.html
Affiliation:	A. Kawakami Lab
Address:	Department of Biological Information Tokyo Institute of Technology 4259 Nagatsuta, Midori-ku Yokohama, 226-8501 Japan
Country:	Japan
Phone:	+81-45-924-5717
Fax:	+81-45-924-5718
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Liu, Z., Meng, Y., Ishikura, A., Kawakami, A. (2024) Live tracking of basal stem cells of the epidermis during growth, homeostasis and injury response in zebrafish. Development (Cambridge, England). 151(2):

Komiya, H., Sato, Y., Kimura, H., Kawakami, A. (2024) Independent mesenchymal progenitor pools respectively produce and maintain osteogenic and chondrogenic cells in zebrafish. Development, growth & differentiation. 66(2):161-171

Tamaki, T., Yoshida, T., Shibata, E., Nishihara, H., Ochi, H., Kawakami, A. (2023) Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities. Biology Open. 12(2):

Zhou, S., Liu, Z., Kawakami, A. (2022) A PI3Kγ signal regulates macrophage recruitment to injured tissue for regenerative cell survival. Development, growth & differentiation. 64(8):433-445

Hamada, H., Uemoto, T., Tanaka, Y., Honda, Y., Kitajima, K., Umeda, T., Kawakami, A., Shinya, M., Kawakami, K., Tamura, K., Abe, G. (2019) Pattern of fin rays along the antero-posterior axis based on their connection to distal radials. Zoological letters. 5:30

Shibata, E., Liu, Z., Kawasaki, T., Sakai, N., Kawakami, A. (2018) Robust and local positional information within a fin ray directs fin length during zebrafish regeneration. Development, growth & differentiation. 60(6):354-364

Shibata, E., Ando, K., Murase, E., Kawakami, A. (2018) Heterogeneous fates and dynamic rearrangement of regenerative epidermis-derived cells during zebrafish fin regeneration. Development (Cambridge, England). 145(8)

Ando, K., Shibata, E., Hans, S., Brand, M., Kawakami, A. (2017) Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance. Developmental Cell. 43(5):643-650.e3

Hasegawa, T., Hall, C.J., Crosier, P.S., Abe, G., Kawakami, K., Kudo, A., Kawakami, A. (2017) Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold. eLIFE. 6

Shibata, E., Ando, K., Kawakami, A. (2017) Transplantation of Mesenchymal Cells Including the Blastema in Regenerating Zebrafish Fin. Bio-protocol. 7:e2109

Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K., Kawakami, A. (2016) Fgf signalling controls diverse aspects of fin regeneration. Development (Cambridge, England). 143:2920-9

Hasegawa, T., Nakajima, T., Ishida, T., Kudo, A., Kawakami, A. (2015) A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration. Developmental Biology. 399(1):80-90

Yoshinari, N., Ando, K., Kudo, A., Kinoshita, M., and Kawakami, A. (2012) Colored medaka and zebrafish: Transgenics with ubiquitous and strong transgene expression driven by the medaka beta-actin promoter. Development, growth & differentiation. 54(9):818-828

Yoshinari, N., and Kawakami, A. (2011) Mature and juvenile tissue models of regeneration in small fish species. The Biological bulletin. 221(1):62-78

Ishida, T., Nakajima, T., Kudo, A., and Kawakami, A. (2010) Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish. Developmental Biology. 340(2):468-479

Yoshinari, N., Ishida, T., Kudo, A., and Kawakami, A. (2009) Gene expression and functional analysis of zebrafish larval fin fold regeneration. Developmental Biology. 325(1):71-81

Parvin, M.S., Okuyama, N., Inoue, F., Islam, M.E., Kawakami, A., Takeda, H., and Yamasu, K. (2008) Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(5):1373-1388

Sultana, N., Nag, K., Hoshijima, K., Laird, D.W., Kawakami, A., and Hirose, S. (2008) Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proceedings of the National Academy of Sciences of the United States of America. 105(12):4763-4768

Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210

Nishidate, M., Nakatani, Y., Kudo, A., and Kawakami, A. (2007) Identification of novel markers expressed during fin regeneration by microarray analysis in medaka fish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(9):2685-2693

Nakatani, Y., Kawakami, A., and Kudo, A. (2007) Cellular and molecular processes of regeneration, with special emphasis on fish fins. Development, growth & differentiation. 49(2):145-154

Islam, M.E., Kikuta, H., Inoue, F., Kanai, M., Kawakami, A., Parvin, M.S., Takeda, H., and Yamasu, K. (2006) Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development. Mechanisms of Development. 123(12):907-924

Watanabe, M., Iwashita, M., Ishii, M., Kurachi, Y., Kawakami, A., Kondo, S., and Okada, N. (2006) Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene. EMBO reports. 7(9):893-897

Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., and Hiraga, T. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquatic toxicology (Amsterdam, Netherlands). 78(2):103-113

Murayama, E., Herbomel, P., Kawakami, A., Takeda, H., and Nagasawa H. (2005) Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mechanisms of Development. 122(6):791-803

Kawakami, A., Nojima, Y., Toyoda, A., Takahoko, M., Satoh, M., Tanaka, H., Wada, H., Masai, I., Terasaki, H., Sakaki, Y., Takeda, H., and Okamoto, H. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Current biology : CB. 15(5):480-488

Kawakami, A., Fukazawa, T., and Takeda, H. (2004) Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(4):693-699

Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., and Kawakami, A. (2004) The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (Cambridge, England). 131(11):2521-2532

Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Developmental Biology. 269(2):381-392

Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M. (2003) Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development (Cambridge, England). 130(12):2705-2716

Karlstrom, R.O., Tyurina, O.V., Kawakami, A., Nishioka, N., Talbot, W.S., Sasaki, H., and Schier, A.F. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development (Cambridge, England). 130(8):1549-1564

Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H., and Araki, K. (2002) Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nature Genetics. 31(2):195-199

Kawakami, A. (2000) [Zebrafish genetics and genomics].. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 45(Suppl. 17):2853-2863

NON-ZEBRAFISH PUBLICATIONS
1. Nishina, S., Kohsaka, S., Yamaguchi, Y., Handa, H., Kawakami, A., Fujisawa, H. and Azuma, N. (1999)
PAX6 expression in the developing human eye. British J. Ophthalmology 83, 723-727.

2. Nomura, T., Kawakami, A., and Fujisawa, H. (1998) Correlation between tectum formation and
expression of two PAX family genes, PAX6 and PAX7, in avian brains. Dev. Growth Differentiation 40,
485-495.

3. Yamamoto, M., Gotoh, Y., Tamura, K., Tanaka, M., Kawakami, A., Ide, H., and Kuroiwa, A. (1998)
Coordinated expression of Hoxa-11 and Hoxa-13 during limb musclepatterning. Development 125,
1325-1335.

4. Kawakami, A., Kimura-Kawakami, M., Nomura, T. and Fujisawa, H. (1997) Distributions of PAX6 and
PAX7 suggest their involvement in both early and late phases of chick brain development. Mech. Dev. 66,
119-130.

5. Ericson, J., Rashbass, A., Schedl, A., Brenner-Morton, S., Kawakami, A., von Heyningen, V., Jessell, T.
M. and Briscoe, J. (1997) Pax6 controls progenitor cell identity and neuronal fate in the spinal cord and
hindbrain in response to graded Shh signaling. Cell 90, 169-180.

6. Fujisawa, H., Kitsukawa, T., Kawakami, A., Takagi, S., Shimizu, M., and Hirata, T. (1997) Roles of a
neuronal cell-surface molecule, neuropilin, in nerve fiberfasciculation and guidance. Cell Tissue Res
290, 465-470.

7. Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. M. (1996) Two critical periods of
Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.

8. Kameyama, T., Murakami, Y., Sutou, F., Kawakami, A., Takagi, S., Hirata, T, and Fujisawa, H. (1996)
Identification of a neuronal cell surface molecule, Plexin, in mouse. Biochem. Biophys. Res. Comm. 226,
524-529.

9. Kameyama, T., Murakami, Y., Sutou, F., Kawakami, A., Takagi, S., Hirata, T, and Fujisawa, H. (1996)
Identification of Plexin family molecules in mouse. Biochem. Biophys. Res. Comm. 226, 396-402.

10. Sugisaki, N., Hirata, T., Naruse. I., Kawakami, A., Kitsukawa, T. and Fujisawa, H. Positional cues
that are strictly localized in the telencephalon induce preferential growth of mitral cell axons. (1996)
J. Neurobiol. 29, 127-137.

11. Kawakami, A., Kitsukawa, T., Takagi, S. and Fujisawa, H. (1996) Developmentally regulated
expression of a cell surface molecule, neuropilin, in the mouse nervous system. J. Neurobiol. 29, 1-17.

12. Kitsukawa, T., Shimono, A., Kawakami, A., Kondoh, H. and Fujisawa, H. (1995) Overexpression of a
membrane potein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous
system and limb. Development 121, 4309-4318.

13. Ohta, K., Mizutani, A., Kawakami, A., Murakami, Y., Kasuya, Y., Takagi, S., Tanaka, H. and Fujisawa, H.
(1995) Plexin: A novel neuronal cell surface molecule that mediates cell adhesion via a homophilic
binding mechanism in the presence of calcium ions. Neuron 14, 1189-1199.

14. Takagi, S., Kasuya, Y., Shimizu, M., Matsuura, T., Tsuboi, M., Kawakami, A. and Fujisawa, H. (1995)
Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Dev. Biol.
170, 207-222.

15. Noguchi, T., Adachi-Yamada, T., Katagiri, T., Kawakami, A., Iwami, M., Ishibashi, J., Kataoka, H.,
Suzuki, A., Go, M. and Ishizaki, H. (1995) Insect prothoracicotropic hormone: a new member of the
vertebrate growth factor superfamily. FEBS letters 376, 251-256.

16. Ishibashi, J., Kataoka, H., Isogai, A., Kawakami, A., Saegusa, H., Yagi, Y., Mizoguchi, A., Ishizaki, H.
and Suzuki, A. (1994) Assignment of disulfide bond location in prothoracicotropic hormone of the
silkworm, Bombyx mori: a homodimeric peptide. Biochemistry 33, 5912-5919.

17. Kimura-Kawakami, M., Iwami, M., Kawakami, A., Nagasawa, H., Suzuki, A. and Ishizaki, H. (1992)
Structure and expression of bombyxin-related peptide genes of the moth Samia cynthia ricini. Gen Comp
Endocrinol 86, 257-268.

18. Kawakami, A., Kataoka, H., Oka, T., Mizoguchi, A., Kimura-Kawakami, M., Adachi, T., Iwami, M.,
Nagasawa, H., Suzuki, A. and Ishizaki, H. (1990) Molecular cloning of the Bombyx mori
prothoracicotropic hormone. Science 247, 1333-1335.

19. Iwami, M., Adachi, T., Kondoh, H., Kawakami, A., Nagasawa, H., Suzuki, A. and Ishizaki, H. (1990) A
novel family C of the genes that encode bombyxin, an insulin-related brain secretory peptide of the
silkmoth Bombyx mori : Isolation and characterization of gene C-1. Insect Biochem. 20, 295-303.

20. Kawakami, A., Iwami, M., Nagasawa, H., Suzuki, A. and Ishizaki, H. (1989) Structure and
organization of four clustered genes that encode bombyxin, an insulin-related brain secretory peptide
of the silkmoth Bombyx mori. Proc. Natl. Acad. Sci. USA 86, 6843-6847.

21. Iwami, M., Kawakami, A., Ishizaki, H., Takahashi, S. Y., Adachi, T., Suzuki, Y., Nagasawa, H. and
Suzuki, A. (1989) Cloning of a gene encoding bombyxin, an insulin-like secretory peptide of the silkmoth
Bombyx mori with prothoracicotropic activity. Develop. Growth & Differ. 31, 31-37.

22. Adachi, T., Takiya, S., Suzuki, Y., Iwami, M., Kawakami, A., Takahashi, S. Y., Ishizaki, H., Nagasawa,
H. and Suzuki, A. (1989) cDNA structure and expression of bombyxin, an insulin-like brain secretory
peptide of the silkmoth Bombyx mori. J. Biol. Chem. 264, 7681-7685.

23. Hirano, S., Nose, A., Hatta, K., Kawakami, A. and Takeichi, M. (1987) Calcium-dependent cell-cell
adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles. J.
Cell. Biol. 105, 2501-2510