ZFIN ID: ZDB-PERS-970217-3
Webb, Sarah E.
Email: barnie@ust.hk
URL: http://home.ust.hk/~aequorin/calcium.htm
Affiliation: Laboratory of Dr. Andrew L. Miller
Address: HKUST Calcium-Aequorin Imaging Laboratory Department of Biology The Hong Kong University of Science and Technology Clear Water Bay Kowloon, Hong Kong
Country:
Phone: 852-2358-7324
Fax: 852-2358-1559
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Ma, O.L., Webb, S.E., and Miller, A.L. Imaging Patterns of Ca2+ Transients During the Blastula Period in Zebrafish Embryos. The Biological bulletin. 207(2):165
Miller, A.L., Leclerc, C., Moreau, M., Webb, S.E. Role of Ca2+ Signaling During Early Pronephric Development in Zebrafish and Xenopus Embryos. The Biological bulletin. 207(2):165
Xu, S., Webb, S.E., Lau, T.C.K., Cheng, S.H. (2018) Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration. Scientific Reports. 8:7199
Kelu, J.J., Webb, S.E., Galione, A., Miller, A.L. (2018) TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons.. Developmental Biology. 438(1):57-68
Kelu, J.J., Webb, S.E., Parrington, J., Galione, A., Miller, A.L. (2017) Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.. Developmental Biology. 425(2):109-129
Webb, S.E., Miller, A.L. (2017) Ca2+ Signalling and Membrane Dynamics During Cytokinesis in Animal Cells.. Advances in experimental medicine and biology. 981:389-412
Chan, C.M., Aw, J.T., Webb, S.E., Miller, A.L. (2016) SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos. Zygote (Cambridge, England). 24(6):880-889
Webb, S. (2016) LARGER, SHARPER & DEEPER. Biotechniques. 61:285-291
Kelu, J.J., Chan, H.L., Webb, S.E., Cheng, A.H., Ruas, M., Parrington, J., Galione, A., Miller, A.L. (2015) Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca2+ signaling during myogenesis in intact zebrafish. The International journal of developmental biology. 59:313-325
Webb, S.E., Goulet, C., Chan, C.M., Yuen, M.Y., and Miller, A.L. (2014) Biphasic assembly of the contractile apparatus during the first two cell division cycles in zebrafish embryos. Zygote (Cambridge, England). 22:218-228
Yuen, M.Y., Webb, S.E., Chan, C.M., Thisse, B., Thisse, C., and Miller, A.L. (2013) Characterization of Ca(2+) signaling in the external yolk syncytial layer during the late blastula and early gastrula periods of zebrafish development. Biochimica et biophysica acta. Molecular cell research. 1833(7):1641-56
Webb, S.E., and Miller, A.L. (2013) Microinjecting holo-aequorin into dechorionated and intact zebrafish embryos. Cold Spring Harbor protocols. 2013(5):pdb.prot072967
Webb, S.E., Chan, C.M., and Miller, A.L. (2013) Introduction of Aequorin into Zebrafish Embryos for Recording Ca(2+) Signaling during the First 48 h of Development. Cold Spring Harbor protocols. 2013(5):383-6
Chan, C.M., Miller, A.L., and Webb, S.E. (2013) Reconstitution of holo-aequorin with apoaequorin mRNA and coelenterazine in zebrafish embryos. Cold Spring Harbor protocols. 2013(5):pdb.prot072975
Webb, S.E., and Miller, A.L. (2013) Ca(2+) signaling during activation and fertilization in the eggs of teleost fish. Cell Calcium. 53(1):24-31
Webb, S.E., Cheung, C.C., Chan, C.M., Love, D.R., and Miller, A.L. (2012) The application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca2+-signalling during the in vivo differentiation of slow muscle cells in zebrafish embryos under normal and dystrophic conditions. Clinical and experimental pharmacology & physiology. 39(1):78-86
Webb, S.E., Fluck, R.A., and Miller, A.L. (2011) Calcium signaling during the early development of medaka and zebrafish. Biochimie. 93(12):2112-25
Zhang, J., Webb, S.E., Ma, L.H., Chan, C.M., and Miller, A.L. (2011) Necessary role for intracellular Ca2+ transients in initiating the apical-basolateral thinning of enveloping layer cells during the early blastula period of zebrafish development. Development, growth & differentiation. 53(5):679-696
Webb, S.E., and Miller, A.L. (2011) Visualization of Ca2+ Signaling During Embryonic Skeletal Muscle Formation in Vertebrates. Cold Spring Harbor protocols. 3(2):a004325
Cheung, C.Y., Webb, S.E., Love, D.R., and Miller, A.L. (2011) Visualization, characterization and modulation of calcium signaling during the development of slow muscle cells in intact zebrafish embryos. The International journal of developmental biology. 55(2):153-74
Leung, C.F., Miller, A.L., Korzh, V., Chong, S.W., Sleptsova-Freidrich, I., and Webb, S.E. (2009) Visualization of stochastic Ca2+ signals in the formed somites during the early segmentation period in intact, normally developing zebrafish embryos. Development, growth & differentiation. 51(7):617-637
Lam, P.Y., Webb, S.E., Leclerc, C., Moreau, M., and Miller, A.L. (2009) Inhibition of stored Ca release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. Development, growth & differentiation. 51(4):429-442
Ma, L.H., Webb, S.E., Chan, C.M., Zhang, J., and Miller, A.L. (2009) Establishment of a transitory dorsal-biased window of localized Ca(2+) signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Developmental Biology. 327(1):143-157
Li, W.M., Webb, S.E., Chan, C.M., and Miller, A.L. (2008) Multiple roles of the furrow deepening Ca2+ transient during cytokinesis in zebrafish embryos. Developmental Biology. 316(2):228-248
Webb, S.E., Li, W.M., and Miller, A.L. (2008) Calcium signalling during the cleavage period of zebrafish development. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 363(1495):1363-1369
Webb, S.E., and Miller, A.L. (2007) Ca(2+) Signalling and early embryonic patterning during zebrafish development. Clinical and experimental pharmacology & physiology. 34(9):897-904
Webb, S.E., and Miller, A.L. (2006) Ca(2+) signaling and early embryonic patterning during the Blastula and Gastrula Periods of Zebrafish and Xenopus development. Biochimica et biophysica acta. Molecular cell research. 1763(11):1192-1208
Montaville, P., Dai, Y., Cheung, C.Y., Giller, K., Becker, S., Michalak, M., Webb, S.E., Miller, A.L., and Krebs, J. (2006) Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. Biochimica et biophysica acta. Molecular cell research. 1763(11):1335-1343
Li, W.M., Webb, S.E., Lee, K.W., and Miller, A.L. (2006) Recruitment and SNARE-mediated fusion of vesicles in furrow membrane remodeling during cytokinesis in zebrafish embryos. Experimental cell research. 312(17):3260-3275
Lee, K.W., Webb, S.E., and Miller, A.L. (2006) Requirement for a localized, IP 3 R-generated Ca 2+ transient during the furrow positioning process in zebrafish zygotes. Zygote (Cambridge, England). 14(2):143-155
Cheung, C.Y., Webb, S.E., Meng, A., and Miller, A.L. (2006) Transient expression of apoaequorin in zebrafish embryos: extending the ability to image calcium transients during later stages of development. The International journal of developmental biology. 50(6):561-569
Cheng, J.C., Miller, A.L., and Webb, S.E. (2004) Organization and function of microfilaments during late epiboly in zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 231(2):313-323
Miller, A.L., Leclerc, C., Moreau, M., Webb, S.E. (2004) Role of Ca2+ Signaling During Early Pronephric Development in Zebrafish and Xenopus Embryos.. The Biological bulletin. 207:165
Ma, O.L., Webb, S.E., Miller, A.L. (2004) Imaging Patterns of Ca2+ Transients During the Blastula Period in Zebrafish Embryos.. The Biological bulletin. 207:165
Lee, K.W., Ho, S.M., Wong, C.H., Webb, S.E., and Miller, A.L. (2004) Characterization of mid-spindle microtubules during furrow positioning in early cleavage period zebrafish embryos. Zygote (Cambridge, England). 12(3):221-230
Lee, K.W., Webb, S.E., and Miller, A.L. (2003) Ca2+ released via IP3 receptors is required for furrow deepening during cytokinesis in zebrafish embryos. The International journal of developmental biology. 47(6):411-421
Webb, S.E. and Miller, A.L. (2003) Calcium signalling during embryonic development. Nature reviews. Molecular cell biology. 4(7):539-551
Webb, S.E. and Miller, A.L. (2003) Imaging intercellular calcium waves during late epiboly in intact zebrafish embryos. Zygote (Cambridge, England). 11(2):175-182
Lee, K.W., Webb, S.E., Ho, S.M., Wong, C.H., and Miller, A.L. (2002) A microtubule array precedes the formation of the cleavage furrow during the first two-cell division cycles in zebrafish embryos. Developmental Biology. 247(2):465-466
Cheng, J.C., Miller, A.L., and Webb, S.E. (2002) Actin-based endocytosis contributes to zebrafish epiboly. The Journal of general physiology. 120(1):46
Cheng, J.C., Miller, A.L., and Webb, S.E. (2001) The role of microfilaments in zebrafish epiboly. The Journal of general physiology. 118(1):40
Webb, S.E. and Miller, A.L. (2000) Calcium signalling during zebrafish embryonic development. BioEssays : news and reviews in molecular, cellular and developmental biology. 22(2):113-123
Leung, C.F., Webb, S.E., and Miller, A.L. (2000) On the mechanism of ooplasmic segregation in single-cell zebrafish embryos. Development, growth & differentiation. 42(1):29-40
Lee, K.W., Webb, S.E., and Miller, A.L. (1999) A wave of free cytosolic calcium traverses zebrafish eggs on activation. Developmental Biology. 214(1):168-180
Pullium, J.K., Dillehay, D.L., and Webb, S. (1999) High mortality in zebrafish (Danio rerio). Contemp. Top. Lab. Anim. Sci.. 38(3):80-83
Gilland, E., Miller, A.L., Karplus, E., Baker, R., Webb, S.E. (1999) Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation. Proc. Natl. Acad. Sci. USA. 96:157-161
Leung, C.F., S.E. Webb, and A.L. Miller (1998) Calcium transients accompany ooplasmic segregation in zebrafish embryos. Development, growth & differentiation. 40:313-326
Webb, S.E., K.W. Lee, E. Karplus, and A.L. Miller (1997) Localized calcium transients accompany furrow positioning, propagation, and deepening during the early cleavage period of zebrafish embryos. Developmental Biology. 192:78-92

NON-ZEBRAFISH PUBLICATIONS
Webb SE. Moreau M. Leclerc C. Miller AL. (2001) Calcium in development: from ion transients to gene expression. Bioessays 23(4):372-374.

Leclerc, C., Webb, S.E., Daguzan, C., Moreau, M., and Miller, A.L. (2000). Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos. J. of Cell Sci. 113: 3519-3529.

Lee KK. Wong CC. Webb SE. Tang MK. Leung AK. Kwok PF. Cai DQ. Chan KM. (1999) Hepatocyte growth factor stimulates chemotactic response in mouse embryonic limb myogenic cells in vitro. Journal of Experimental Zoology. 283(2):170-80.

Yew DT. Li WP. Webb SE. Lai HW. Zhang L. (1999) Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison. Experimental Gerontology. 34(1):117-33

Webb SE. Appleford N. Gaskin P. Lenton JR. (1998) Gibberallins in internodes and ears of wheat containing different dwarfing alleles. Phytochem 47(5):671-677.

Bejon, P.A., Bannister, L.H., Fowler, R.E., Fookes, R.E. Webb, S.E., Wright, A, and Mitchell, G.H. (1997). A role for microtubules in Plasmodium falciparum merozoite invasion. Parasitology 114: 1-6.

Webb SE. Lee KK. Tang MK. Ede DA. (1997) Fibroblast growth factors 2 and 4 stimulate migration of mouse embryonic limb myogenic cells. Developmental Dynamics. 209(2):206-16.

Webb SE. Lee KK. (1997) Effect of platelet-derived growth factor isoforms on the migration of mouse embryo limb myogenic cells. International Journal of Developmental Biology. 41(4):597-605.

Webb, S.E., Lee, K.K.H. and Ede, D.A. (1997). Effect of FGF-2 and -4 on mouse embryonic limb myoblast migration. Dev. Dyn. 209: 206-216.

Webb, S.E., Fowler, R.E., O'Shaughnessy, C., Pinder, J.C., Dluzewski, A.R., Grazter, W.B., Bannister, L.H. and Mitchell, G.H. (1996). Contractile protein system in the asexual stages of the malaria parasite Plasmodium falciparum. Parasitology 112: 451-457.

Webb, S.E., Pollard, J.P. and Jones, G.E. (1996). Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J. Cell Sci. 109(4): 793-803.

Yew, D.T., Webb, S.E., and Lam, E.T.K. (1996). Neurotransmitters and neuropeptides in the developing human facial nucleus. Neurosci. Lett. 206: 65-68.

Yew DT. Webb SE. Wong CK. Hui KS. (1996) Differential expression of the soluble 170 kDa brain protein in the fetal and adult human brain. International Journal of Developmental Neuroscience. 14(5):551-7.

Lee, K.K.H., Webb, S.E., Cai, D.Q., Sze, L.Y., Lam, K.H., Li, Z. and Paulin, D. (1995). Desmin transgene expression in mouse somites requires the presence of the neural tube. Int. J. Dev. Biol. 39: 469-475.

Sze, L.-Y., Lee, K.K.H., Webb, S.E., Li, Z. and Paulin, D. (1995). The migration of myogenic cells from the somites to the fore-limb buds of developing mouse embryos.Dev. Dyn. 203: 324-336.

Davies, J.S., Enjalbal, C., Wise, C.J., Webb, S.E. and Jones, G.E. (1994). Synthesis and cell-adhesion properties of cyclo {-Arg-Gly-Asp-Ser-Lys-}, a constrained analogue of the active domain of fibronectin. J. Chem. Soc. Perkin Trans. 1: 2011-2015.