ZFIN ID: ZDB-PERS-961101-8
Kobayashi, Makoto
Email: makobayash@md.tsukuba.ac.jp
Affiliation: Kobayashi Lab
Address: Molecular and Developmental Biology Faculty of Medicine University of Tsukuba 1-1-1 Tennodai Tsukuba, Ibaraki, 305-8575 Japan
Country: Japan
Phone: 81-29-853-8457
Fax: 81-29-853-5977
Orcid ID:


Fuse, Y., Endo, Y., Araoi, S., Daitoku, H., Suzuki, H., Kato, M., Kobayashi, M. (2017) The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: the demonstration of Nrf2-dependent anti-oxidative action using a zebrafish model. Free radical biology & medicine. 115:405-411
Fuse, Y., Kobayashi, M. (2017) Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time. Molecules. 22(3)
Osborne, O.J., Mukaigasa, K., Nakajima, H., Stolpe, B., Romer, I., Philips, U., Lynch, I., Mourabit, S., Hirose, S., Lead, J.R., Kobayashi, M., Kudoh, T., Tyler, C.R. (2016) Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology. 10(9):1276-86
Vong, L.B., Kobayashi, M., Nagasaki, Y. (2016) Evaluation of the Toxicity and Antioxidant Activity of Redox Nanoparticles in Zebrafish (Danio rerio) Embryos. Molecular pharmaceutics. 13(9):3091-7
Fuse, Y., Nguyen, V.T., Kobayashi, M. (2016) Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. Toxicol. Appl. Pharmacol.. 305:136-42
Nguyen, V.T., Fuse, Y., Tamaoki, J., Akiyama, S.I., Muratani, M., Tamaru, Y., Kobayashi, M. (2016) Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish. Oxidative medicine and cellular longevity. 2016:5720574
Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., Fukamizu, A. (2015) PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Science advances. 1:e1500615
Takeuchi, M., Fuse, Y., Watanabe, M., Andrea, C.S., Takeuchi, M., Nakajima, H., Ohashi, K., Kaneko, H., Kobayashi-Osaki, M., Yamamoto, M., Kobayashi, M. (2015) LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proceedings of the National Academy of Sciences of the United States of America. 112(45):13922-7
Fuse, Y., Nakajima, H., Nakajima-Takagi, Y., Nakajima, O., Kobayashi, M. (2015) Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes to cells : devoted to molecular & cellular mechanisms. 20(7):590-600
Mukaigasa, K., Nguyen, L.T., Li, L., Nakajima, H., Yamamoto, M., and Kobayashi, M. (2012) Genetic Evidence of an Evolutionarily Conserved Role for Nrf2 in the Protection against Oxidative Stress. Molecular and cellular biology. 32(21):4455-4461
Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
Tsujita, T., Li, L., Nakajima, H., Iwamoto, N., Nakajima-Takagi, Y., Ohashi, K., Kawakami, K., Kumagai, Y., Freeman, B.A., Yamamoto, M., and Kobayashi, M. (2011) Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. Genes to cells : devoted to molecular & cellular mechanisms. 16(1):46-57
Iida, A., Sakaguchi, K., Sato, K., Sakurai, H., Nishimura, D., Iwaki, A., Takeuchi, M., Kobayashi, M., Misaki, K., Yonemura, S., Kawahara, A., and Sehara-Fujisawa, A. (2010) Metalloprotease-dependent onset of blood circulation in zebrafish. Current biology : CB. 20(12):1110-1116
Takeuchi, M., Kaneko, H., Nishikawa, K., Kawakami, K., Yamamoto, M., and Kobayashi, M. (2010) Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis. Development, Growth & Differentiation. 52(2):245-250
Kobayashi, M., Li, L., Iwamoto, N., Nakajima-Takagi, Y., Kaneko, H., Nakayama, Y., Eguchi, M., Wada, Y., Kumagai, Y., and Yamamoto, M. (2009) The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds. Molecular and cellular biology. 29(2):493-502
Li, L., Kobayashi, M., Kaneko, H., Nakajima-Takagi, Y., Nakayama, Y., and Yamamoto, M. (2008) Molecular evolution of Keap1: Two Keap1 molecules with distinctive IVR structures are conserved among fish. The Journal of biological chemistry. 283(6):3248-3255
Ando, H., Kobayashi, M., Tsubokawa, T., Uyemura, K., Furuta, T., and Okamoto, H. (2005) Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. Developmental Biology. 287(2):456-468
Suzuki, T., Takagi, Y., Osanai, H., Li, L., Takeuchi, M., Katoh, Y., Kobayashi, M., and Yamamoto, M. (2005) Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish. The Biochemical journal. 388(Pt 1):65-73
Takagi, Y., Kobayashi, M., Li, L., Suzuki, T., Nishikawa, K, and Yamamoto, M. (2004) MafT, a new member of the small Maf protein family in zebrafish. Biochemical and Biophysical Research Communications. 320(1):62-69
Kawakami, K., Takeda, H., Kawakami, N., Kobayashi, M., Matsuda, N., and Mishina, M. (2004) A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Developmental Cell. 7(1):133-144
Kimura-Yoshida, C., Kitajima, K., Oda-Ishii, I., Tian, E., Suzuki, M.,Yamamoto, M., Suzuki, T., Kobayashi, M., Aizawa, S., and Matsuo, I. (2004) Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development (Cambridge, England). 131(1):57-71
Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305
Kobayashi, M., Itoh, K., Suzuki, T., Osanai, H., Nishikawa, K., Katoh, Y., Takagi, Y., and Yamamoto, M. (2002) Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes to cells : devoted to molecular & cellular mechanisms. 7(8):807-820
Kobayashi, M., Nishikawa, K., and Yamamoto, M. (2001) Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish embryos. Development (Cambridge, England). 128(12):2341-2350
Kobayashi, M., Nishikawa, K., Suzuki, T., and Yamamoto, M. (2001) The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. Developmental Biology. 232(2):315-326
Kajihara, M., Kawauchi, S., Kobayashi, M., Ogino, H., Takahashi, S., and Yasuda, K. (2001) Isolation, characterization, and expression analysis of zebrafish large Mafs. J. Biochem. (Tokyo). 129(1):139-146
Kobayashi, M., Osanai, H., Kawakami, K., and Yamamoto, M. (2000) Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. Mechanisms of Development. 98(1-2):151-155
Kobayashi, M. (2000) Study for the molecular mechanism of transcription using the zebrafish system. Seikagaku. The Journal of Japanese Biochemical Society. 72(9):1168-1172
Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982
Toyama, R., Kobayashi, M., Tomita, T., and Dawid, I.B. (1998) Expression of LIM-domain binding protein (ldb) genes during zebrafish embryogenesis. Mechanisms of Development. 71:197-200