Person
Hart, Nathan H.
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Biography and Research Interest
Developmental biology, fertilization, cytoskeleton, zebrafish egg
Fertilization of the vertebrate egg triggers a complex cascade of responses at the cell surface, including secretion of vesicles by exocytosis, the retrieval of membrane by endocytosis, movement of the sperm into the egg cytoplasm, and formation of the second polar body with re-entry into the cell cycle. These events of early development are tightly regulated both temporally and spatially. The research in my laboratory is focused on egg structure, the role(s) of the cortical actin-based cytoskeleton in modulating these early changes in egg organization, and the intracellular signals involved in regulating actin organization. Our model system for analysis is the zebrafish egg.
Fertilization of the vertebrate egg triggers a complex cascade of responses at the cell surface, including secretion of vesicles by exocytosis, the retrieval of membrane by endocytosis, movement of the sperm into the egg cytoplasm, and formation of the second polar body with re-entry into the cell cycle. These events of early development are tightly regulated both temporally and spatially. The research in my laboratory is focused on egg structure, the role(s) of the cortical actin-based cytoskeleton in modulating these early changes in egg organization, and the intracellular signals involved in regulating actin organization. Our model system for analysis is the zebrafish egg.
Non-Zebrafish Publications