Eckhert, Curt

(1) the environmental and genetic regulation of nuclear selenoproteins and (2) the accumulation of photosensitive molecules from the environment into tissues where they can act as photo acceptors and generate cytotoxic molecular species. Dr. Eckhert's research has shown that the degeneration of the microvascular circulation (capillaries) associated with aging is prevented by the incorporation of selenium (Se) into two nuclear polypeptides within microvascular cells. Isolation of the gene involved in challenges to the redox state of the cell is an area of current interest. Molecules that become excited upon exposure to light can be taken into the body through food, water, air and by contact with the skin. Excitation of these molecules in tissues can result in the formation of a wide variety of potentially cytotoxic molecules. Dr. Eckhert has studied the biological regulation of flavins as model photosensitive compounds and the impact of excessive exposure to flavins on cells in the retina of the eye.