Biography and Research Interest

Genomic instability, cellular differentiation, cancer, zebrafish functional genomics, anatomic atlas, and virtual microscopy.

Publications

Non-Zebrafish Publications

Cheng, K.C. and Smith, G.R. (1984) Recombinational hotspot activity of Chi-like sequences. J. Mol. Biol. 180:371-377.

Smith, G.R., Amundsen, S.K., Chaudhury, A.M., Cheng, K.C., Ponticelli, A.S., Roberts, C.M., Schultz, D.W. and Taylor, A.F. (1984) Roles of RecBC enzyme and Chi sites in homologous recombination. Cold Spring Harbor Symp. Quant. Biol. 49:485-495.

Smith, G.R., Amundsen, S.K., Cheng, K.C., McKittrick, N.H., Ponticelli, A.S., Roberts, C.M., Schultz, D.W. , Taylor, A.F. and Thibodeaux, S. (1987) Mechanism and control of homologous recombination. In Mechanisms of DNA replication and recombination. UCLA Symposium on Molecular and Cellular Biology New Series, Volume 47. Alan R. Liss, Inc. New York, New York, pages 567-583.

Cheng, K.C. and Smith G.R. (1987) Cutting of Chi-like sequences by RecBCD enzyme. J. Mol. Biol. 194:747-750.

Cheng, K.C. and Smith, G.R. (1989) Distribution of Chi-stimulated recombinational exchanges and heteroduplex endpoints in phage lambda. Genetics 123:5-17.

Loeb, L.A. and Cheng, K.C. (1990) Errors in DNA synthesis: A source of spontaneous mutations. Mutat. Res. 238:297-304.

Cheng, K.C. and Dias, M. (1991) Genomic Instability and Cancer: Cause and Effect (invited Keystone Meeting review) Cancer Cells 3:188-192.

Loeb, L.A., McBride, T.J ., Reid, T.M. and Cheng, K.C. (1991) Mutagenic spectra of oxygen free radicals. In New Horizons in Molecular Toxicology, pp. 35-39, eds., G.S. Probst, J.J. Vodicnik and M.A. Dorato, published for Lilly Research Laboratories by FASEB, 1991.

Cheng, K.C., Cahill, D.S., Preston, B.D., Singer, B. and Loeb, L.A. (1991) The vinyl chloride DNA derivative, N2,3-ethenoguanine, causes G to A transitions in E. coli. Proc. Natl. Acad. Sci., U.S.A. 88:9974-9978.

Cheng, K.C., Cahill, D.S., Kasai, Nishimura, S. and Loeb, L.A. (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J. Biol. Chem. 267:166-172.

Cheng, K.C. and Loeb, L.A. (1993) Genomic Instability and tumor progression: mechanistic considerations. Advances in Cancer Research 60:121-156.

Cheng, K.C. and Loeb, L.A. (1996) Genomic stability and instability: A working paradigm. Chapter 2, Current Topics in Microbiology and Immunology, (ed. M.B. Kastan) Springer-Verlag, Berlin, pp. 5-18.

Hite, J.M., Eckert, K.E., Kauffman, E.J., and Cheng, K.C. (1996) Factors affecting fidelity of DNA synthesis during PCR amplification of d(CA)n@d(G-T)n microsatellite repeats. Nucleic Acids Res. 24:2429-2434.

Cheng, K.C. (1998) "A Day Well Spent for Science: a First Experience with Scientific Congressional Advocacy", The ASCB Newsletter, Vol. 21, No. 3 (April 1998).

Cheng, K. (1998) You can't win the Indy 500 in a Yugo: Help NSF funding: An oped. In HMS Beagle: The BioMedNet Magazine (http://biomednet.com/hmsbeagle/1998/28/people/op_ed.htm) Issue 28 (Apr. 17)