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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-668
Byrnes, Lucy
Email: lucy.byrnes@nuigalway.ie
URL: http://www.nuigalway.ie/faculties_departments/biochemistry/staff/byrnes/
Affiliation: Byrnes Lab
Address: Biochemistry School of Natural Sciences National University of Ireland, Galway University Road Galway, Ireland
Country: Ireland
Phone: 353-91-492416
Fax: 353-91-525700
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Our current research interests lie in the following areas:

1. Molecular and cellular events at the midblastula transition in zebrafish.

2. The role of IGF signalling during embryonic development, using zebrafish as a model species.


PUBLICATIONS
Cunningham, S., Brennan-Fournet, M.E., Ledwith, D., Byrnes, L., and Joshi, L. (2013) Effect of nanoparticle stabilisation and physicochemical properties on exposure outcome: Acute toxicity of silver nanoparticle preparations in zebrafish (Danio rerio). Environmental science & technology. 47(8):3883-92
Moriarty, M.A., Ryan, R., Lalor, P., Dockery, P., Byrnes, L., and Grealy, M. (2012) Loss of plakophilin 2 disrupts heart development in zebrafish. The International journal of developmental biology. 56(9):711-718
Hartnett, L., Glynn, C., Nolan, C.M., Grealy, M., and Byrnes, L. (2010) Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos. The International journal of developmental biology. 54(4):573-583
Tsalavouta, M., Astudillo, O., Byrnes, L., and Nolan, C.M. (2009) Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus. Evolution & development. 11(5):546-558
Martin, E.D., Moriarty, M.A., Byrnes, L., and Grealy, M. (2009) Plakoglobin has both structural and signalling roles in zebrafish development. Developmental Biology. 327(1):83-96
Moriarty, M.A., Martin, E.D., Byrnes, L., and Grealy, M. (2008) Molecular cloning and developmental expression of plakophilin 2 in zebrafish. Biochemical and Biophysical Research Communications. 367(1):124-129
O'Boyle, S., Bree, R.T., McLoughlin, S., Grealy, M., and Byrnes, L. (2007) Identification of zygotic genes expressed at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 358(2):462-468
Nolan, C.M., McCarthy, K., Eivers, E., Jirtle, R.L., and Byrnes, L. (2006) Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Development genes and evolution. 216(3):144-151
Bree, R.T., McLoughlin, S., Jin, S.W., McMeel, O.M., Stainier, D.Y., Grealy, M., and Byrnes, L. (2005) nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 333(3):722-728
Eivers, E., McCarthy, K., Glynn, C., Nolan, C.M., and Byrnes, L. (2004) Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo. The International journal of developmental biology. 48(10):1131-1140
Ayaso, E., Nolan, C.M., and Byrnes, L. (2002) Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression. Molecular and Cellular Endocrinology. 191(2):137-148
Brabazon, E.D., Bree, R.T., Carton, M.W., Grealy, M., and Byrnes, L. (2002) Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development. BBA Gene Structure and Expression. 1576(1-2):203-208

NON-ZEBRAFISH PUBLICATIONS
Geoghegan, E. and Byrnes, L. (2008) Mouse induced pluripotent stem cells. Int. J.Dev. Biol. in press

Bree, R.T., Stenson-Cox, C., Grealy, M., Byrnes, L., Gorman, A. and Samali, A. (2002) Cellular longevity: role of apoptosis and replicative senescence. Biogerontology 3 (4) 195-206.

Carton, M.W., Schmitz, M., Cutts, C.J., Kelly, A.K., Hill, J.A., Brabazon, E.D., Adams, C.E. and Byrnes, L. (2002)Expressed sequence tags in larval Arctic charr (Salvelinus alpinus) Fish Physiol. Biochem. 26 231-238

Stenson, C. McNair, A., Byrnes, L., Murphy, M., Smith, T. and Gannon, F. (2000) Atlantic salmon HNF-3/fork head; cDNA sequence, evolution, expression and functional analysis. DNA Cell Biol. 19 59-68.

Fluoriot, G., Ducouret, B., Byrnes, L and Valotaire, Y. (1998) Transcriptional regulation of the rainbow trout albumin gene by estrogen. J. Mol. Endocrinol. 20 355-62.

Stenson C., McNair, A., Byrnes, L. and Gannon, F. (1996) Cloning of an Atlantic salmon transcription factor. Biochem. Soc. Trans. 106S 24.

Deryckere, F., Byrnes, L., Wagner, A., McMorrow, T. and Gannon, F. (1995) Salmon HNF1: cDNA sequence, evolution, tissue specificity and binding to the salmon serum albumin promoter. J. Mol. Biol. 247 1-10.

Stenson, C., McNair, A., Byrnes, L. and Gannon, F. (1996) Cloning of an Atlantic salmon transcription factor. Biochem. Soc. Trans. 24 106S.

Deryckere, F., Byrnes, L., Wagner, A., McMorrow, T. and Gannon, F. (1995) Salmon HNF1: cDNA sequence, evolution, tissue specificity and binding to the salmon serum albumin promoter. J. Mol. Biol. 247 1-10.

Hardiman, G., Byrnes, L. and Gannon, F. (1994) An analysis of highly expressed salmon liver genes during smoltification in the Atlantic salmon (Salmo salar L.) Molecular Marine Biol. Biotech. 3 51-56.

Hardiman, G., Byrnes, L., Peden, J., Wolff, J., and Gannon, F. (1994) Cloning and sequencing of an Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII gene expression during parr-smolt transformation. Molecular Marine Biol. Biotech. 3 210-216.

Byrnes, L. and F. Gannon (1992) Sequence analysis of a second cDNA for salmon serum albumin. Gene 120 319-320.

Powell, R., Higgins, D.G., Wolff, J., Byrnes, L., Stack, M. Sharp, P.M. and F. Gannon (1991) The salmon gene encoding apolipoprotein A-I: cDNA sequence, tissue expression and evolution. Gene 104 155-161.

Powell, R., Byrnes, L. and F. Gannon (1991) Sequence of a cDNA clone encoding an Atlantic salmon ribosomal protein. Gene 101 303-304.

Powell, R., Byrnes, L., Barry, T. and F. Gannon (1990) A rapid procedure to isolate major abundance mRNA transcripts and study the transcription profile of a tissue. Technique 2 213-215.

Byrnes, L. and Gannon, F. (1990) Atlantic salmon (Salmo salar) serum albumin: cDNA sequence, evolution and expression. DNA and Cell Biology 9 647-655.

Byrnes, L., Luo, C.-C., Li, W.-H., Yang, C.-Y. and L. Chan (1987) Chicken apolipoprotein A-I; cDNA sequence, Tissue expression and evolution. Biochemical Biophysical Research Communications 148 485-492.