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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-419
Orban, Laszlo
Email: laszlo@tll.org.sg
URL:
Affiliation: Orban Lab
Address: Reproductive Genomics Group Temasek Life Sciences Laboratory The National University of Singapore 1 Research Link Singapore, 117 604 Singapore
Country: Singapore
Phone: 65-6872-7413
Fax: 65-6872-7007
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Sex determination and gonad differentiation of teleosts, with special attention to cyprinids;

Evolution of sex chromosomes in vertebrates;

Reproductive behavior of bonytongues.


PUBLICATIONS
Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
Pradhan, A., Khalaf, H., Ochsner, S.A., Sreenivasan, R., Koskinen, J., Karlsson, M., Karlsson, J., McKenna, N.J., Orban, L., and Olsson, P.E. (2012) Activation of NF-kappaB prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. The Journal of biological chemistry. 287(45):37926-37938
Liew, W.C., Bartfai, R., Lim, Z., Sreenivasan, R., Siegfried, K.R., and Orban, L. (2012) Polygenic sex determination system in zebrafish. PLoS One. 7(4):e34397
Orban, L., Sreenivasan, R., and Olsson, P.E. (2009) Long and winding roads: Testis differentiation in zebrafish. Molecular and Cellular Endocrinology. 312(1-2):35-41
Sreenivasan, R., Cai, M., Bartfai, R., Wang, X., Christoffels, A., and Orban, L. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One. 3(3):e1791
Hossain, M.S., Larsson, A., Scherbak, N., Olsson, P.E., and Orban, L. (2008) Zebrafish Androgen Receptor: Isolation, Molecular, and Biochemical Characterization. Biology of reproduction. 78(2):361-369
Wang, X.G., and Orban, L. (2007) Anti-Mullerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males. Developmental dynamics : an official publication of the American Association of Anatomists. 236(5):1329-1338
Wang, X.G., Bartfai, R., Sleptsova-Freidrich, I., and Orban, L. (2007) The timing and extent of 'juvenile ovary' phase are highly variable during zebrafish testis differentiation. Journal of Fish Biology. 70(sa):33
Christoffels, A., Bartfai, R., Srinivasan, H., Komen, H., and Orban, L. (2006) Comparative genomics in cyprinids: common carp ESTs help the annotation of the zebrafish genome. BMC Bioinformatics. 7 (Suppl 5):S2
Yue, G.H., and Orban, L. (2005) A simple and affordable method for high-throughput DNA extraction from animal tissues for polymerase chain reaction. Electrophoresis. 26(16):3081-3083
Bartfai, R., Balduf, C., Hilton, T., Rathmann, Y., Hadzhiev, Y., Tora, L., Orbán, L., and Muller, F. (2004) TBP2, a Vertebrate-Specific Member of the TBP Family, Is Required in Embryonic Development of Zebrafish. Current biology : CB. 14(7):593-598
Li, Y., Chia, J.M., Bartfai, R., Christoffels, A., Ding, K., Yue, G.H., Ho,M.Y., Hill, J.A., Stupka, E. and Orban, L (2004) Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Comparative and functional genomics. 5(5):403-418
Bartfai, R. and Orbán, L. (2003) The vasa locus in zebrafish: multiple RGG boxes from intragenic duplications. DNA and cell biology. 22(1):47-54
Adam, A., Bartfai, R., Lele, Z., Krone, P.H., and Orbán, L. (2000) Heat-inducible expression of a reporter gene detected by transient assay in zebrafish. Experimental cell research. 256(1):282-290
Müller, F., Williams, D.W., Kobolak, J., Gauvry, L., Goldspink, G., Orbán, L., and Maclean, N. (1997) Activator effect of coinjected enhancers on the muscle-specific expression of promoters in zebrafish embryos. Molecular reproduction and development. 47(4):404-412
Williams, D. Müller, F., Lavender, F.L., Orbán, L., and Maclean, N. (1996) High transgene activity in the yolk syncytial layer affects quantitative transient expression assays in zebrafish (Danio rerio) embryos. Transgenic Research. 5:433-442
Müller, F., Gauvry, L., Williams, D., Kobolak, J., Maclean, N., Orbán, L., and Goldspink, G. (1996) The use of transient lacZ expression in fish embryos for comparative analysis of activity of cloned regulatory elements. In Gene expression and manipulation in aquatic organisms. S.J. Ennion and G. Goldspink, eds., Soc. Exp. Biol. Sem. Ser. 58, Cambridge, UK: Cambridge University Press. :175-199
Horvath, L. and Orbán, L. (1995) Genome and gene manipulation in the common carp. Aquaculture (Amsterdam, Netherlands). 129:157-181
Szelei, J., Varadi, L., Müller, F., Erdelyi, F., Orbán, L., Horvath, L, and Duda, E. (1994) Liposome-mediated gene transfer in fish embryos. Transgenic Research. 3:116-119
Müller, F., Lele, Z., Varadi, L., Menczel, L., and Orbán, L. (1993) Efficient transient expression system based on square pulse electroporation and in vivo luciferase assay of fertilized fish eggs. FEBS letters. 324:27-32
Müller, F., Ivics, Z., Erdelyi, F. Papp, T., Varadi, L., Horvath, L., Maclean, N., and Orbán, L. (1992) Introducing foreign genes into fish eggs with electroporated sperm as a carrier. Molecular marine biology and biotechnology. 1:276-281

NON-ZEBRAFISH PUBLICATIONS
Yue, G.H. and L. Orban: Novel microsatellites from the green swordtail (Xiphophorus helleri) also display polymorphism in guppy (Poecilia reticulata), Molecular Ecology Notes 4: 474-476 (2004)

Yue, G.H. and L. Orban: Characterization of microsatellites within genes of goldfish (Carassius auratus), Molecular Ecology Notes 4: 404-405 (2004)

Yue, G.H., Y. Li, F. Chen, L.C. Lim and L. Orban: Monitoring the genetic diversity of three Asian arowana (Scleropages formosus) captive stocks using AFLP and microsatellites. Aquaculture 237: 89-102 (2004)

Yue, G.H., M.Y. Ho, L. Orban and H. Komen: Microsatellites within genes and ESTs of common carp and cross-amplification in silver crucian carp, Aquaculture 234: 85-98 (2004)

Bartfai, R., S. Egedi, G.H. Yue, B. Kovacs, B. Urbanyi, G. Tamas, L. Horvath and L. Orban: Genetic analysis of two common carp broodstocks by RAPD and microsatellite markers, Aquaculture 219(1-4): 157-167 (2003)

Yue, G.H., D. Ong, C.C. Wong, L.C. Lim and L. Orban: A strain-specific and a sex-associated STS marker for Asian arowana (Scleropages formosus), Aquaculture Research 34: 951-957 (2003)

Yue, G.H., B. Kovacs and L. Orban: Microsatellites from Clarias batrachus and their polymorphism in seven additional catfish species, Mol. Ecol.Notes 3: 465-468 (2003)

Li, Y., J.A. Hill, G. Yue, F. Chen and L. Orban: Extensive search does not identify genomic sex marker in Tetraodon nigroviridis, J. Fish Biol., 61(5): 1314-1317 (2002)

Yue, G.H., Y. Li, T.M. Chao, R. Chou and L. Orban: Novel microsatellites from Asian seabass (Lates calcarifer) and their application to broodstock analysis, Marine Biotech. 4: 503-511 (2002)

Yue, G.H. and L. Orban: Polymorphic microsatellites from the silver crucian carp (Carassius auratus gibelio Bloch) and cross-amplification in common carp (Cyprinus carpio L), Mol. Ecol. Notes, 2(4): 534-536 (2002)

Yue, G.H., Y. Li, S. Cho, L.C. Lim and L. Orban: Comparison of three DNA marker systems for assessing genetic diversity in Asian arowana (Scleropages formosus), Electrophoresis 23: 1025-1032 (2002)

Yue, G.H. and L. Orban: Microsatellites from genes show polymorphism in two related tilapia species, Molecular Ecology Notes 2002, 11 (<), Available from http://dx.doi.org/10.1046/j.1471-8278 . 2001.00159.x

Kovacs, B., S. Egedi, R. Bartfai and L. Orban: Male-specific DNA markers from African catfish (Clarias gariepinus), Genetica 11: 267-276 (2001)

Yue, G.H. and L. Orban: Rapid isolation of PCR-ready DNA from fresh and preserved fish scales, Marine Biotech. 3: 199-204 (2001)

Yue, G.H., Y. Li and L. Orban: Characterization of microsatellites in the IGF-2 and GH genes of Asian seabass (Lates calcarifer), Marine Biotech. 3: 1-3 (2001)

Yue, G.H., Y. Li, J.A. Hill and L. Orban: Microsatellites from the compact genome of the green spotted pufferfish (Tetraodon nigroviridis), Mol. Ecol. 9: 2205-2206 (2000)

Yue, G.H., F. Chen and L. Orban: Rapid isolation and characterization of microsatellites from the genome of Asian arowana (Scleropages formosus), Mol. Ecol. 9: 1007-1009 (2000)

Bercsényi, M., I Magyary, B. Urbányi, L. Orbán and L. Horváth: Hatching out goldfish from common carp eggs: Interspecific androgenesis between two cyprinid species. Genome 41(4): 573-579 (1998)