Person
Mariappan, Indumathi
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Biography and Research Interest
Our lab is interested in understanding eye development and disease using iPSC-derived retinal organoids as in vitro models and zebrafish as in vivo model systems.
Our group is currently focused on:
(1) The genetics of retinal and anterior segment development.
(2) Molecular basis of inherited retinal diseases and anterior segment dysgenesis.
Our group is currently focused on:
(1) The genetics of retinal and anterior segment development.
(2) Molecular basis of inherited retinal diseases and anterior segment dysgenesis.
Non-Zebrafish Publications
Divya Pidishetty, Santhosh Kumar Damera, Murali Murugavel et al. Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish, 27 August 2025, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-7346082/v1].
Pidishetty D, Maddileti S, Mahato S, Agrawal T, Naik M, Kannabiran C, Jalali S, Mariappan I. Generation, and characterization of a Stargardt disease-specific induced pluripotent stem cell line (LVPEIi008-A) with a homozygous nonsense mutation in exon 44 of ABCA4. Stem Cell Res. 2024 Aug;78:103458.
Pidishetty D, Maddileti S, Mahato S, Agrawal T, Pulimamidi VK, Naik M, Kannabiran C, Jalali S, Mariappan I. Generation of two induced pluripotent stem cell lines (LVPEIi007-B, LVPEIi008-B) from patients harboring homozygous mutation in ABCA4 (c.6088C>T) using non-integrative Sendai virus-based approach. Stem Cell Res. 2024 Jun;77:103418.