Person

Mariappan, Indumathi

Person ID: ZDB-PERS-250929-1
URL: http://lvpei.org/about-us/our-team/research/indumathi-mariappan
Affiliation: Indumathi Mariappan Lab
Address: Center for Ocular Regeneration (CORE) Prof. Brien Holden Eye Research Center (BHERC) Hyderabad Eye Research Foundation (HERF) Kallam Anji Reddy (KAR) Campus, L V Prasad Eye Institute (LVPEI) Road No. 2, Banjara Hills, LV Prasad Marg, Hyderabad 500034, Telangana.
Country: India
Phone: 91-40-6810 2288, 6810 2511
Fax: +91-40-6810 2535
ORCID ID: 0000-0001-7059-3030

Biography and Research Interest

Our lab is interested in understanding eye development and disease using iPSC-derived retinal organoids as in vitro models and zebrafish as in vivo model systems.
Our group is currently focused on:
(1) The genetics of retinal and anterior segment development.
(2) Molecular basis of inherited retinal diseases and anterior segment dysgenesis.

Publications

Non-Zebrafish Publications

Divya Pidishetty, Santhosh Kumar Damera, Murali Murugavel et al. Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish, 27 August 2025, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-7346082/v1].

Pidishetty D, Maddileti S, Mahato S, Agrawal T, Naik M, Kannabiran C, Jalali S, Mariappan I. Generation, and characterization of a Stargardt disease-specific induced pluripotent stem cell line (LVPEIi008-A) with a homozygous nonsense mutation in exon 44 of ABCA4. Stem Cell Res. 2024 Aug;78:103458.

Pidishetty D, Maddileti S, Mahato S, Agrawal T, Pulimamidi VK, Naik M, Kannabiran C, Jalali S, Mariappan I. Generation of two induced pluripotent stem cell lines (LVPEIi007-B, LVPEIi008-B) from patients harboring homozygous mutation in ABCA4 (c.6088C>T) using non-integrative Sendai virus-based approach. Stem Cell Res. 2024 Jun;77:103418.