ZFIN ID: ZDB-PERS-210304-2
Pradhan, Ajay
Email: ajay.pradhan@oru.se
URL:
Affiliation: Pradhan Lab
Address: Örebro University
Country:
Phone: +46736564268
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ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476
Shu, T., Zhai, G., Pradhan, A., Olsson, P.E., Yin, Z. (2020) Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. General and comparative endocrinology. 295:113490
Pradhan, A., Bereketoglu, C., Martin, L., Duhagon, J., Olsson, P.E. (2019) The food preservative ethoxyquin impairs zebrafish development, behavior and alters gene expression profile. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 135:110926
Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
Saju, J.M., Hossain, M.S., Liew, W.C., Pradhan, A., Thevasagayam, N.M., Tan, L.S.E., Anand, A., Olsson, P.E., Orbán, L. (2018) Heat Shock Factor 5 Is Essential for Spermatogenesis in Zebrafish. Cell Reports. 25:3252-3261.e4
Pradhan, A., Olsson, P.E. (2018) Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. General and comparative endocrinology. 265:15-21
Pradhan, A., Ivarsson, P., Ragnvaldsson, D., Berg, H., Jass, J., Olsson, P.E. (2017) Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. The Science of the total environment. 584-585:1138-1146
Pradhan, A., Olsson, P. (2016) Regulation of Zebrafish Gonadal Sex Differentiation. AIMS Molecular Science. 3:567-584
Pradhan, A., Olsson, P.E. (2015) Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins. Behavioral and brain functions : BBF. 11:23
Pradhan, A., Olsson, P.E. (2015) Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. General and comparative endocrinology. 217-218:81-91
Pradhan, A., Asnake, S., Kharlyngdoh, J.B., Modig, C., Olsson, P.E. (2015) In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chemico-biological interactions. 233:35-45
Pradhan, A., Olsson, P.E. (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of reproduction. 91(2):33
Pradhan, A., Kharlyngdoh, J.B., Asnake, S., and Olsson, P.E. (2013) The brominated flame retardant TBECH activates the zebrafish (Danio rerio) androgen receptor, alters gene transcription and causes developmental disturbances. Aquatic toxicology (Amsterdam, Netherlands). 142-143C:63-72
Pradhan, A., Khalaf, H., Ochsner, S.A., Sreenivasan, R., Koskinen, J., Karlsson, M., Karlsson, J., McKenna, N.J., Orban, L., and Olsson, P.E. (2012) Activation of NF-kappaB prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. The Journal of biological chemistry. 287(45):37926-37938

NON-ZEBRAFISH PUBLICATIONS
1.Bereketoglu C, Nacar G, Sari T,Mertoglu B, Pradhan A.
Transcriptomics Analysis of Nonylphenol Effect on Saccharomuces cerevisiae.
PeerJ. 2021

2.Seyoum A, Pradhan A, Jass J, Olsson PE. Perfluorinated alkyl substances impede
growth, reproduction, lipid metabolism and lifespan in Daphnia magna. Sci Total
Environ. 2020

3.Pradhan A, Hammerquist AM, Khanna A, Curran SP. The C-Box Region of MAF1
Regulates Transcriptional Activity and Protein Stability. J Mol Biol. 2017.
429(2):192-207.

4.Pradhan A, Kharlyngdoh JB, Asnake S, Olsson PE. The brominated flame retardant
TBECH activates the zebrafish (Danio rerio) androgen receptor, alters gene
transcription and causes developmental disturbances. Aquat Toxicol. 2013. 142-
143:63-72.

5.Seyoum A, Pradhan A. Effect of phthalates on development, reproduction, fat
metabolism and lifespan in Daphnia magna Sci Total Environ. 2019. 654:969-977.

6.Kharlyngdoh JB, Pradhan A, Olsson PE. Androgen receptor modulation following
combination exposure to brominated flame-retardants. Sci Rep. 2018. 8(1):4843.

7.Pradhan A, Olsson PE, Jass J. Di(2-ethylhexyl) phthalate and diethyl phthalate
disrupt lipid metabolism, reduce fecundity and shortens lifespan of
Caenorhabditis elegans. Chemosphere. 2017. 190:375-382.

8.Pradhan A, Hammerquist AM, Khanna A, Curran SP. The C-Box Region of MAF1
Regulates Transcriptional Activity and Protein Stability. J Mol Biol. 2017.
429(2):192-207.

9.Kharlyngdoh JB, Asnake S, Pradhan A, Olsson PE. TBECH, 1,2-dibromo-4- (1,2
dibromoethyl) cyclohexane, alters androgen receptor regulation in response to
mutations associated with prostate cancer. Toxicol Appl Pharmacol. 2016. 307:91-
101.

10.Asnake S, Pradhan A, Kharlyngdoh JB, Modig C, Olsson PE. The brominated flame
retardants TBP-AE and TBP-DBPE antagonize the chicken androgen receptor and act
as potential endocrine disrupters in chicken LMH cells. Toxicol In Vitro. 2015.
29(8):1993-2000.

11.Kharlyngdoh JB, Pradhan A, Asnake S, Walstad A, Ivarsson P, Olsson PE.
Identification of a group of brominated flame-retardants as novel androgen
receptor antagonists and potential neuronal and endocrine disrupters. Environ
Int. 2015. 74:60-70.

12.El Marghani A, Pradhan A, Seyoum A, Khalaf H, Ros T, Forsberg LH, Nermark T,
Osterman L, Wiklund U, Ivarsson P, Jass J, Olsson PE. Contribution of
pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to
inland waters. Sci Total Environ. 2014. 488- 489:228-35.

13.Asnake S, Pradhan A, Banjop-Kharlyngdoh J, Modig C, Olsson PE. 1,2- Dibromo-4-
(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor
activation and gene regulation in chicken LMH cells. Environ Toxicol Chem. 2014.
33(4):891-9.