ZFIN Person: Saunders, Timothy Edward

ZFIN ID: ZDB-PERS-190912-1

ZFIN ID: ZDB-PERS-190912-1

Saunders, Timothy Edward

Email:	dbsste@nus.edu.sg
URL:	http://mbi.nus.edu.sg/timothy-saunders/saunders-lab/
Affiliation:	Mechanics of Development lab
Address:	Mechanobiology Institute, National University of Singapore
Country:
Phone:	+6566011552
Fax:
ORCID ID:	0000-0001-5755-0060

BIOGRAPHY AND RESEARCH INTERESTS

Physicist turned developmental biologists interested in morphogenesis, signalling, and temporal regulation of development.

PUBLICATIONS

Mendieta-Serrano, M.A., Dhar, S., Ng, B.H., Narayanan, R., Lee, J.J.Y., Ong, H.T., Toh, P.J.Y., Röllin, A., Roy, S., Saunders, T.E. (2022) Slow muscles guide fast myocyte fusion to ensure robust myotome formation despite the high spatiotemporal stochasticity of fusion events. Developmental Cell. 57(17):2095-2110.e5

Toh, P.J.Y., Lai, J.K.H., Hermann, A., Destaing, O., Sheetz, M.P., Sudol, M., Saunders, T.E. (2022) Optogenetic control of YAP cellular localisation and function. EMBO reports. 23(9):e54401

Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464

Lai, J.K.H., Toh, P.J.Y., Cognart, H.A., Chouhan, G., Saunders, T.E. (2022) DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. eLIFE. 11:

Bosze, B., Ono, Y., Mattes, B., Sinner, C., Gourain, V., Thumberger, T., Tlili, S., Wittbrodt, J., Saunders, T.E., Strähle, U., Schug, A., Scholpp, S. (2020) Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish. Histochemistry and cell biology. 154(5):463-480

Tlili, S., Yin, J., Rupprecht, J.F., Mendieta-Serrano, M.A., Weissbart, G., Verma, N., Teng, X., Toyama, Y., Prost, J., Saunders, T.E. (2019) Shaping the zebrafish myotome by intertissue friction and active stress. Proceedings of the National Academy of Sciences of the United States of America. 116(51):25430-25439

Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4

Krieger, J.W., Singh, A.P., Bag, N., Garbe, C.S., Saunders, T.E., Langowski, J., Wohland, T. (2015) Imaging fluorescence (cross-) correlation spectroscopy in live cells and organisms. Nature Protocols. 10:1948-74

NON-ZEBRAFISH PUBLICATIONS
H. Connahs, S. Tlili, J. van Creij, T. Y. J. Loo, T. Banerjee, T. E. Saunders* and A. Monteiro*. Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process. Development 146, 169367 (2019)

L. Durrieu, D. Kirrmaier, T. Schneidt, I. Kats, L. Hufnagel*, T. E. Saunders* and M. Knop*. Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis. Molecular Systems Biology 14, e8355 (2018)

S. Zhang, C. Amourda, D. Garfield and T. E. Saunders*. Selective Filopodia Adhesion Ensures Robust Cell Matching in the Drosophila Heart. Developmental Cell 46, 189 (2018).

J. Chong, C. Amourda and T. E. Saunders*. Temporal development of Drosophila embryos is highly robust across a wide temperature range. Journal of the Royal Society: Interface 15, 20180304 (2018)

J.-F. Rupprecht, K. H. Ong, J. Yin, A. Huang, H. H. Q Dinh, S. Zhang, A. P. Singh, W. Yu*, and T. E. Saunders*. Geometric constraints induce cellular skew and apical-to-basal neighbor exchange in curved epithelial tissues. Molecular Biology of the Cell 28, 3582 (2017)

A. Huang, C. Amourda, S. Zhang, N. S. Tolwinski and T. E Saunders*. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo, ELife 6, e26258 (2017)

A. Singh, R. Galland, G. Grenci, J.-B. Subarita, V. Studer, V. Viasnoff* and T. E. Saunders*. Rapid multiplexed and multiplane fluorescence correlation spectroscopy using single-objective light-sheet microscopy, Biophysical Journal 112, 133-142 (2017)