ZFIN Person: Mruk, Karen

ZFIN ID: ZDB-PERS-190306-1

ZFIN ID: ZDB-PERS-190306-1

Mruk, Karen

Email:	mrukk23@ecu.edu
URL:	https://www.mruklab.org/
Affiliation:	Mruk Lab
Address:	Assistant Professor East Carolina University Department of Pharmacology and Toxicology 600 Moye Boulevard Greenville, NC 27834
Country:	United States
Phone:	(252) 744-1171
Fax:
ORCID ID:	0000-0003-4560-4951

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Mruk, K., Ciepla, P., Piza, P.A., Alnaqib, M.A., Chen, J.K. (2020) Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development (Cambridge, England). 147(12):

Hwang, S., Mruk, K., Rahighi, S., Raub, A.G., Chen, C.H., Dorn, L.E., Horikoshi, N., Wakatsuki, S., Chen, J.K., Mochly-Rosen, D. (2018) Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nature communications. 9:4045

NON-ZEBRAFISH PUBLICATIONS
Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH Jr. Mutant SOD1
protein increases Nav1.3 channel excitability. J Biol Phys. 2016
Jun;42(3):351-70. doi: 10.1007/s10867-016-9411-x. Epub 2016 Apr 12. Erratum in: J
Biol Phys. 2016 Jun;42(3):371. PubMed PMID: 27072680; PubMed Central PMCID:
PMC4942418.

Mruk K, Kobertz WR. Bioreactive Tethers. Adv Exp Med Biol. 2015;869:77-100.
doi: 10.1007/978-1-4939-2845-3_5. Review. PubMed PMID: 26381941.

Mruk K, Chen JK. Thinking big with small molecules. J Cell Biol. 2015 Apr
13;209(1):7-9. doi: 10.1083/jcb.201501084. PubMed PMID: 25869661; PubMed Central
PMCID: PMC4395478.

Mruk K, Farley BM, Ritacco AW, Kobertz WR. Calmodulation meta-analysis:
predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 2014
Jul;144(1):105-14. doi: 10.1085/jgp.201311140. Epub 2014 Jun 16. PubMed PMID:
24935744; PubMed Central PMCID: PMC4076516.

Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. Structural
insights into neuronal K+ channel-calmodulin complexes. Proc Natl Acad Sci U S A.
2012 Aug 21;109(34):13579-83. doi: 10.1073/pnas.1207606109. Epub 2012 Aug 6.
PubMed PMID: 22869708; PubMed Central PMCID: PMC3427091.

Mruk K, Kobertz WR. Discovery of a novel activator of KCNQ1-KCNE1 K channel
complexes. PLoS One. 2009;4(1):e4236. doi: 10.1371/journal.pone.0004236. Epub
2009 Jan 21. PubMed PMID: 19156197; PubMed Central PMCID: PMC2617778.

O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. Xenopus laevis oocytes infected
with multi-drug-resistant bacteria: implications for electrical recordings. J Gen
Physiol. 2011 Aug;138(2):271-7. doi: 10.1085/jgp.201110661. PubMed PMID:
21788613; PubMed Central PMCID: PMC3149439.

Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo
MJ, Chan FK. Preligand assembly domain-mediated ligand-independent association
between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc
Natl Acad Sci U S A. 2005 Dec 13;102(50):18099-104. Epub 2005 Nov 30. PubMed
PMID: 16319225; PubMed Central PMCID: PMC1312398.