ZFIN ID: ZDB-PERS-190107-1
Samarut, Eric
Email: eric.samarut@umontreal.ca
URL: http://ca.linkedin.com/in/eric-samarut-6a56b598
Affiliation: Samarut Lab
Address: Dept. Neuroscience University of Montréal CRCHUM Tour Viger R09.706 900 Saint-Denis Montréal, Québec H3G 1A4 Canada
Country: Canada
Phone: 514-756-9429
Fax:
ORCID ID: 0000-0001-7818-2009


BIOGRAPHY AND RESEARCH INTERESTS
I am currently a senior post-doctoral fellow in the laboratory of Pierre Drapeau at the Research Center of the University of Montréal Hospital Center. Drapeau’s laboratory has been investigating the fundamental molecular mechanisms involved in the development of the vertebrate central nervous system. The group focuses on neuromuscular diseases such as ALS that represent a model of choice to investigate such developmental processes in a disorderly versus healthy context. In this thriving research environment, I started a new independent field of research in my host laboratory that aims at performing functional genomics of idiopathic epilepsies using zebrafish. I am now actively seeking for an academic position to conduct my epilepsy neuroscience research project using zebrafish as a model. Eventually, my work could pave the way for new therapeutic strategies for these diseases. More particularly, I foresee the use of patient-specific zebrafish models to develop precision medicine. Driven by a desire to fast-track scientific innovation, I also pursued an MBA specialized in Science and Engineering, thus broadening my view of the research industry. I co-founded two biotechs using zebrafish for preclinical studies.


PUBLICATIONS
Burrows, D.R.W., Samarut, É., Liu, J., Baraban, S.C., Richardson, M.P., Meyer, M.P., Rosch, R.E. (2020) Imaging epilepsy in larval zebrafish. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 24:70-80
Rosch, R., Burrows, D.R.W., Jones, L.B., Peters, C.H., Ruben, P., Samarut, É. (2019) Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks. Frontiers in Cellular Neuroscience. 13:556
Liao, M., Kundap, U., Rosch, R.E., Burrows, D.R.W., Meyer, M.P., Bencheikh, B.O.A., Cossette, P., Samarut, É. (2019) Targeted knockout of GABA receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae. Disease models & mechanisms. 12(11):
Gibert, Y., Samarut, E., Ellis, M.K., Jackman, W.R., Laudet, V. (2019) The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish. Proceedings. Biological sciences. 286:20190401
Samarut, E., Chalopin, D., Riché, R., Allard, M., Liao, M., Drapeau, P. (2019) Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. PLoS One. 14:e0216159
Samarut, É., Nixon, J., Kundap, U.P., Drapeau, P., Ellis, L.D. (2019) Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity. Frontiers in pharmacology. 10:226
Riché, R., Liao, M., Pena, I.A., Leung, K.Y., Lepage, N., Greene, N., Sarafoglou, K., Schimmenti, L.A., Drapeau, P., Samarut, É. (2018) Glycine decarboxylase deficiency-induced motor dysfunction in zebrafish is rescued by counterbalancing glycine synaptic level. JCI insight. 3(21):
Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi-Yanicostas, N., Drapeau, P. (2018) γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 59(11):2061-2074
Swaminathan, A., Hassan-Abdi, R., Renault, S., Siekierska, A., Riché, R., Liao, M., de Witte, P.A.M., Yanicostas, C., Soussi-Yanicostas, N., Drapeau, P., Samarut, É. (2018) Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development. Current biology : CB. 28(12):1924-1937.e5
Samarut, É., Dona, M., Yoganantharjah, P. (2017) Zebrafish Ride the Danube's Wave for the 10th European Zebrafish Meeting. Zebrafish. 15(1):79-83
Dzieciolowska, S., Larroque, A.L., Kranjec, E.A., Drapeau, P., Samarut, E. (2017) The larvicide pyriproxyfen blamed during the Zika virus outbreak does not cause microcephaly in zebrafish embryos. Scientific Reports. 7:40067
Samarut, É. (2016) Zebrafish embryos as in vivo test tubes to unravel cell-specific mechanisms of neurogenesis during neurodevelopment and in diseases.. Neurogenesis (Austin, Tex.). 3:e1232678
Samarut, É., Lissouba, A., Drapeau, P. (2016) A simplified method for identifying early CRISPR-induced indels in zebrafish embryos using High Resolution Melting analysis. BMC Genomics. 17:547
Samarut, E., Bekri, A., Drapeau, P. (2016) Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Frontiers in molecular neuroscience. 9:22
Samarut, E., Fraher, D., Laudet, V., Gibert, Y. (2015) ZebRA: An overview of retinoic acid signaling during zebrafish development. Biochimica et biophysica acta. Gene regulatory mechanisms. 1849(2):73-83
Samarut, E., Gaudin, C., Hughes, S., Gillet, B., de Bernard, S., Jouve, P.E., Buffat, L., Allot, A., Lecompte, O., Berekelya, L., Rochette-Egly, C., and Laudet, V. (2014) Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Molecular endocrinology (Baltimore, Md.). 28(2):260-272
Seritrakul, P., Samarut, E., Lama, T.T., Gibert, Y., Laudet, V., and Jackman, W.R. (2012) Retinoic acid expands the evolutionarily reduced dentition of zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(12):5014-5024
Samarut, E., Amal, I., Markov, G.V., Stote, R., Dejaegere, A., Laudet, V., and Rochette-Egly, C. (2011) Evolution of Nuclear Retinoic Acid Receptor Alpha (RARα) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation. Mol. Biol. Evol.. 28(7):2125-37

NON-ZEBRAFISH PUBLICATIONS