ZFIN Person: Swaminathan, Amrutha

ZFIN ID: ZDB-PERS-180515-1

ZFIN ID: ZDB-PERS-180515-1

Swaminathan, Amrutha

Email:	amrutha.swaminathan@iisertvm.ac.in
URL:	https://amruthaswaminathan.wixsite.com/molneurodev
Affiliation:	Swaminathan Lab
Address:	Molecular Neurodevelopment Lab, School of Biology, IISER Thiruvananthapuram, Maruthamala PO, Vithura, Thiruvananthapuram 695551.
Country:	India
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Ph.D work in JNCASR and ENS-Lyon on the role of chromatin associated proteins and histone modifications in neuronal development and differentiation. Worked in Montreal for a post-doc on zebrafish models of epilepsy and ALS. Now interested in hypothalamus development in zebrafish.

PUBLICATIONS

Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973

Peles, G., Swaminathan, A., Levkowitz, G. (2022) Glucocorticoid-sensitive period of corticotroph development-Implications for mechanisms of early life stress. Journal of neuroendocrinology. 35(11):e13229

Biran, J., Gliksberg, M., Shirat, I., Swaminathan, A., Levitas-Djerbi, T., Appelbaum, L., Levkowitz, G. (2020) Publisher Correction: Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. Scientific Reports. 10:12734

Biran, J., Gliksberg, M., Shirat, I., Swaminathan, A., Levitas-Djerbi, T., Appelbaum, L., Levkowitz, G. (2020) Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. Scientific Reports. 10:9559

Swaminathan, A., Basu, M., Bekri, A., Drapeau, P., Kundu, T.K. (2019) The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation. Frontiers in molecular neuroscience. 12:41

Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi-Yanicostas, N., Drapeau, P. (2018) γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 59(11):2061-2074

Swaminathan, A., Hassan-Abdi, R., Renault, S., Siekierska, A., Riché, R., Liao, M., de Witte, P.A.M., Yanicostas, C., Soussi-Yanicostas, N., Drapeau, P., Samarut, É. (2018) Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development. Current biology : CB. 28(12):1924-1937.e5

Swaminathan, A., Bouffard, M., Liao, M., Ryan, S., Bennion Callister, J., Pickering-Brown, S.M., Armstrong, G.A.B., Drapeau, P. (2018) Expression of C9orf72-related dipeptides impairs motor function in a vertebrate model. Human molecular genetics. 27(10):1754-1762

NON-ZEBRAFISH PUBLICATIONS
1. Samarut E, Swaminathan A, Riché R, Liao M, Hassan-Abdi R, Renault S, Allard M, Dufour L, Cossette P, Soussi-Yanicostas N and Drapeau P-Loss-of-function of GABA receptor alpha 1 subunit causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 2018;59(11):2061-2074.

2. Swaminathan A, Hassan-Abdi R, Renault S, Siekierska A, Riché R, Liao M, de Witte PAM, Yanicostas C, Soussi-Yanicostas N, Drapeau P* and Samarut E*-Non-canonical mTOR-independent role of DEPDC5 in regulating GABAergic network development. Curr Biol. 2018; 28 (12):1924-1937.

3. Swaminathan A, Bouffard M, Liao M, Ryan S, Bennion-Callister J, Pickering-Brown SM, Armstrong GA, Drapeau P-Expression of C9orf72-related dipeptides impairs motor function in a vertebrate model. Hum Mol Genet. 2018; 27(10):1754-1762.

1. Dhanasekaran K, Bose A, Rao V, Boopathi R, Shankar S, Rao V, Swaminathan A, Vasudevan M, Taneja R and Kundu TK-Unravelling the role of Aurora A beyond centrosomes and spindle assembly: Implications in muscle differentiation. FASEB J. 2018 (ahead of print-doi: 10.1096/fj.201800997).

2. Swaminathan A, Delage H, Chatterjee S, Belgarbi-Dutron L, Cassel R, Martinez N, Cosquer B, Kumari S, Mongelard F, Lannes B, Cassel JC, Boutillier AL, Bouvet P, Kundu TK-Transcriptional coactivator and chromatin protein PC4 is involved in hippocampal neurogenesis and spatial memory extinction. J Biol Chem. 2016;291 (39):20303-14.

3. Dhanasekaran K, Kumari S, Boopathi R, Shima H, Swaminathan A, Bachu M, Ranga U, Igarashi K, Kundu TK-Multifunctional Human Transcriptional Co-activator Protein PC4 is a Substrate of Aurora Kinases and Activates the Aurora Enzymes. FEBS J. 2016. 283 (6):968-985.

4. Selvi RB, Swaminathan A, Chatterjee S, Shanmugam MK, Li F, Ramakrishnan GB, Siveen KS, Chinnathambi A, Emam ZM, Alharbi SA, Basha J, Bhat A, Vasudevan M, Dharmarajan A, Sethi G, Kundu TK- Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model. Oncotarget. 2015; 6 (41):43806-18.

5. Selvi BR*, Swaminathan A*, Maheshwari U, Nagabhushana A, Mishra RK, Kundu TK-CARM1 regulates astroglial lineage through transcriptional regulation of Nanog and posttranscriptional regulation by miR92a. Mol Biol Cell. 2015; 26(2):316-26. (*equal contributors/first authors).

6. Swaminathan A, Kumar M, Halder Sinha S, Schneider-Anthony A, Boutillier AL, Kundu TK-Modulation of neurogenesis by targeting epigenetic enzymes using small molecules: an overview. ACS Chem Neurosci. 2014; 5(12):1164-77.

7. Schneider A, Chatterjee S, Bousiges O, Selvi BR, Swaminathan A, Cassel R, Blanc F, Kundu TK, Boutillier AL-Acetyltransferases (HATs) as targets for neurological therapeutics. Neurotherapeutics. 2013; 10 (4):568-88.

8. Kumari S, Swaminathan A, Chatterjee S, Senapati P, Boopathi R and Kundu TK-Chromatin organization, Epigenetics and Differentiation: An evolutionary perspective. Subcell Biochem. 2012; 61:3-35. (Epigenetics:development and disease).