|ZFIN ID: ZDB-PERS-170512-1|
BIOGRAPHY AND RESEARCH INTERESTS
Ralph Nelson’s interest in retina began with an undergraduate thesis project at Amherst College studying the mechanisms of rhodopsin bleaching and opsin interactions with vitamin A analogues. Long interested in electronics, he learned microelectrode recording and synaptic mechanisms in retina in a PhD thesis with John Dowling, then at Johns Hopkins. Dr. Nelson studied rod and cone circuits in cat retina, learning monochromatic stimulation techniques as a Post-Doctoral Student with Peter Gouras, then at the National Eye Institute, where Dr. Nelson became a tenured NIH investigator. Much of this circuitry tracing work combining microelectrode stains with electron microscopic reconstructions, the latter, done in collaboration with Helga Kolb, then also at NIH. Michael Freed and Andrew Mariani studied mammalian retinal circuits as Post-Doctoral Students with Dr. Nelson. Victoria Connaughton convinced Nelson to switch to studies of zebrafish retinal circuitry during her Post-Doctoral tenure in the Nelson lab in the late 1990’s. Dr. Nelson currently manages a zebrafish retinal electrophysiology lab, and is an Editor of Webvision.
Guo, C., Deveau, C., Zhang, C., Nelson, R., Wei, X. (2020) Zebrafish Crb1, localizing uniquely to the cell membranes around cone photoreceptor axonemes, alleviates light damage to photoreceptors and modulates cones' light responsiveness. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(37):7065-7079
Deveau, C., Jiao, X., Suzuki, S.C., Krishnakumar, A., Yoshimatsu, T., Hejtmancik, J.F., Nelson, R.F. (2020) Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish). PLoS Genetics. 16:e1008869
Nelson, R.F., Balraj, A., Suresh, T., Torvund, M., Patterson, S.S. (2019) Strain variations in cone wavelength peaks in situ during zebrafish development. Visual neuroscience. 36:E010
Li, L., Jiao, X., D'Atri, I., Ono, F., Nelson, R., Chan, C.C., Nakaya, N., Ma, Z., Ma, Y., Cai, X., Zhang, L., Lin, S., Hameed, A., Chioza, B.A., Hardy, H., Arno, G., Hull, S., Khan, M.I., Fasham, J., Harlalka, G.V., Michaelides, M., Moore, A.T., Coban Akdemir, Z.H., Jhangiani, S., Lupski, J.R., Cremers, F.P.M., Qamar, R., Salman, A., Chilton, J., Self, J., Ayyagari, R., Kabir, F., Naeem, M.A., Ali, M., Akram, J., Sieving, P.A., Riazuddin, S., Baple, E.L., Riazuddin, S.A., Crosby, A.H., Hejtmancik, J.F. (2018) Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genetics. 14:e1007504
Tanvir, Z., Nelson, R.F., DeCicco-Skinner, K., Connaughton, V.P. (2018) One month of hyperglycemia alters spectral responses of the zebrafish photopic ERG. Disease models & mechanisms. 11(10):