ZFIN Person: Duan, Xiaohong

ZFIN ID: ZDB-PERS-170209-18

ZFIN ID: ZDB-PERS-170209-18

Duan, Xiaohong

Email:	xhduan@fmmu.edu.cn
URL:
Affiliation:	Xiaohong Duan Lab
Address:	Department of Oral Biology Clinic of Oral Rare and Genetic Diseases School of Stomatology The Fourth Military Medical University 145 West Changle Road Xi'an, Shaanxi 710032 CHINA
Country:
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ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My lab is interested in the genetic disorders of craniofacial and oral regions and their molecular mechanisms involving tooth and bone development. We focus on the ion channels or transporters and related channelopathies. We use zebrafish to help us to understand the genetic diseases and common diseases of craniofacial and oral regions. We have very good zebrafish larva models of dental fluorosis.
Besides zebrafish model, we also use mouse and other in vitro methods to help us understand the molecular mechanism of craniofacial and oral disorders.

PUBLICATIONS

Zhang, Y., Ji, D., Li, L., Yang, S., Zhang, H., Duan, X. (2019) ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth. Theranostics. 9:1387-1400

Li, L., Yang, S., Zhang, Y., Ji, D., Jin, Z., Duan, X. (2018) ATP6V1H regulates the growth and differentiation of bone marrow stromal cells. Biochemical and Biophysical Research Communications. 502(1):84-90

Zhao, W., Zhang, Y., Yang, S., Hao, Y., Wang, Z., Duan, X. (2018) Analysis of two transcript isoforms of vacuolar ATPase subunit H in mouse and zebrafish. Gene. 638:66-75

Zhang, Y., Huang, H., Zhao, G., Yokoyama, T., Vega, H., Huang, Y., Sood, R., Bishop, K., Maduro, V., Accardi, J., Toro, C., Boerkoel, C.F., Lyons, K., Gahl, W.A., Duan, X., Malicdan, M.C., Lin, S. (2017) ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genetics. 13:e1006481

Zhang, Y., Ke, Y., Zheng, X., Liu, Q., Duan, X. (2017) Correlation between genotype and phenotype in three families with Peutz-Jeghers Syndrome. Experimental and Therapeutic Medicine. 13(2):507-514

Zhang, Y., Zhang, Y., Zheng, X., Xu, R., He, H., Duan, X. (2016) Grading and quantification of dental fluorosis in zebrafish larva. Archives of oral biology. 70:16-23

Wang, H., Pan, M., Ni, J., Zhang, Y., Zhang, Y., Gao, S., Liu, J., Wang, Z., Zhang, R., He, H., Wu, B., Duan, X. (2016) ClC-7 Deficiency Impairs Tooth Development and Eruption. Scientific Reports. 6:19971

Jiao, Y., Zhu, B., Chen, J., Duan, X. (2015) Fluorescent Sensing of Fluoride in Cellular System. Theranostics. 5(2):173-187

Zhang, Y., Zhang, C., Peng, G., Duan, X. (2014) Characteristics of craniofacial bone development of zebrafish. Kou qiang yi xue yan jiu = Journal of oral science research. 30(2):97-99

NON-ZEBRAFISH PUBLICATIONS
1. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, Sood R, Bishop K, Maduro V, Accardi J, Toro C, Boerkoel CF, Lyons K,Gahl WA, Duan X*, Malicdan MC*, Lin S*. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 2017 Feb 3;13(2):e1006481
2. Yanli Zhang, Yao Ke, Xueni Zheng, qing Liu*, Xiaohong Duan*. Correlation between genotype and phenotype in three families with Peutz-Jeghers Syndrome. Experimental and Therapeutic Medicine.2017, 13(2):507-514.
3. Yan Li Zhang, Chang Ning Wang, Zhi Peng Fan , Yang Jiao, Xiao Hong Duan*. Education Status of Oral Genetics at the Fourth Military Medical University and other Chinese Dental Schools. China Chin J Dent Res. 2016, 19(4):225-229.
4. Yang S, Duan X*. Epigenetics, Bone Remodeling and Osteoporosis, Curr Stem Cell Res Ther. 2016 Dec 21. [Epub ahead of print]
5. Xiaohong Duan#*, Jin Liu#, Xueni Zheng#, Zhe Wang, Yanli Zhang, Ying Hao, Tielin Yang, Hongwen Deng. Deficiency of ATP6V1H Causes Bone Loss by Inhibiting Bone Resorption and Bone Formation through the TGF-β1 Pathway. Theranostics. 2016; 6(12): 2183-2195.
6. Zhang Y, Zhang Y, Zheng X, Xu R, He H*, Duan X*. Grading and quantification of dental fluorosis in zebrafish larva. Arch Oral Biol. 2016 May 31;70:16-23. doi: 10.1016/j.archoralbio.2016.05.021. [Epub ahead of print]
7. Wang H, Pan M, Ni J, Zhang Y, Zhang Y, Gao S, Liu J, Wang Z, Zhang R, He H*, Wu B*, Duan X*. ClC-7 Deficiency Impairs Tooth Development and Eruption. Sci Rep. 2016 Feb 1;6:19971. doi: 10.1038/srep19971.
8. Duan X*, Liu Z, Gan Y, Xia D, Li Q, Li Y, Yang J, Gao S, Dong M. Mutations in COL1A1 Gene Change Dentin Nanostructure. Anat Rec (Hoboken). 2016 Apr;299(4):511-9. doi: 10.1002/ar.23308. Epub 2016 Jan 22.
9. Wang H, Wang R, Wang Z, Liu Q, Mao Y, Duan X*. ClC-3 chloride channel functions as a mechanically sensitive channel in osteoblasts. Biochem Cell Biol. 2015 Dec;93(6):558-65. doi: 10.1139/bcb-2015-0018. Epub 2015 Jul 13.
10. Xue Y, Ni J, Zhou M, Wang W, Liu Y, Yang Y*, Duan X*. Genetic variation analysis in a Chinese Maffucci syndrome patient. J Craniomaxillofac Surg. 2015 Sep;43(7):1248-55. doi: 10.1016/j.jcms.2015.05.017. Epub 2015 Jun 3.
11. Jiao Y, Zhou M, Yang Y, Zhou J, Duan X*. Cherubism misdiagnosed as giant cell tumor: a case report and review of literature. Int J Clin Exp Med 2015;8(3):4656-4663. www.ijcem.com /ISSN: 1940-5901/ IJCEM0005310
12. Xue Y, Wang L, Xia D, Li Q, Gao S, Dong M, Cai T, Shi S, He L, Hu K, Mao T, Duan X*. Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations. J Dent Res. 2015 May;94(5):674-81. doi: 10.1177/0022034515573964. Epub 2015 Mar 2. （IF4.139）
13. Jiao Y, Zhu B, Chen J, Duan X*. Fluorescent Sensing of Fluoride in Cellular System. Theranostics 2015; 5(2): 173-187. doi:10.7150/thno.9860 (IF 7.827)
14. Pan M, Ni J, He H, Gao S, Duan X*. New Paradigms on siRNA Local Application. BMB Rep. 2015 Mar;48(3):147-52.
15. Yang T, Zhang Y, Zheng D, Hao Y, Snead ML, Duan X*. High-fluoride promoted phagocytosis-induced apoptosis in a matured ameloblast-like cell line. Arch Oral Biol. 2015 Jan;60(1):84-90. doi: 10.1016/j.archoralbio.2014.09.001. Epub 2014 Sep 17.
16. Liu Q, Wang W, Zhang L, Zhao L, Song W, Duan X, Zhang Y*. Involvement of N-cadherin/β-catenin interaction in the micro/nanotopography induced indirect mechanotransduction.Biomaterials. 2014 Aug;35(24):6206-18. doi: 10.1016/j.biomaterials.2014.04.068. Epub 2014 May 10.
17. Duan X*. Ion Channels, Channelopathies, and Tooth Formation. J Dent Res. 2014 Feb;93(2):117-25. doi: 10.1177/0022034513507066. Epub 2013 Sep 27. (Invited Critical Reviews of Oral Biology and Oral Medicine)
18. Shi S, Duan X*, Shao J*, Duan Q, Peng S. Dens invaginatus in ancient Chinese teeth of 2,000 years ago. Anat Rec (Hoboken). 2013 Oct; 296 (10):1628-33. doi: 10.1002/ar.22738. Epub 2013 Jul 16.
19. Duan X*, Markello T, Adams D, Toro C, Tifft C, Gahl WA, Boerkoel CF. Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases program in China. Front Med. 2013 Sep; 7 (3):389-94. doi: 10.1007/s11684-013-0281-3. Epub 2013 Jul 15.
20. Li L, Wang P, Liu D, Shao J*, Duan X*. Hereditary Constitution Analysis of Ancient Chinese in Shaolingyuan, Xi’an, China. Nat Sci. 2013, 5, 947-954. doi: 10.4236/ns.2013.58115.
21. Yang T, Zhang Y, Li Y, Hao Y, Zhou M, Dong N, Duan X*. High amounts of fluoride induce apoptosis/cell death in matured ameloblast-like LS8 cells by downregulating Bcl-2. Arch Oral Biol. 2013 Sep;58(9):1165-73. doi: 10.1016/j.archoralbio.2013.03.016. Epub 2013 Apr 15.
22. Zheng D, Duan X*. A novel mutation in NF1 gene in a Chinese patient with Legius syndrome like café au lait spots. Case Reports in Clinical Medicine, 2013, 2, 141-142
23. Duan X*, Yang T, Zhang Y; Wen X; Xue Y, Zhou M. Odontoblast-like MDPC-23 Cells Function as Odontoclasts with the RANKL/M-CSF Induction. Archs Oral Biol, 2012, 58(3): 272-8, Epub 2012, Jul 4
24. Wen X, Wang X, Duan X*. High immunoglobulin E in a Chinese Papillon-Lefèvre syndrome patient with novel compound mutations of cathepsin C. J Dermatol, 2012, 39(7):664-5, Epub 2012 Jan 6
25. Zhao Y, Wang L, Liu Y, Akiyama K, Chen C, Atsuta I, Zhou T, Duan X, Jin Y, Shi S*. Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw. Calcif Tissue Int, 2012 Dec;91(6):400-8. Epub 2012 Oct 12.
26. Xue Y, Wang W, Mao T*, Duan X*. Report of two Chinese patients suffering from CLCN7-related osteopetrosis and root dysplasia. J Craniomaxillofac Surg, 2012 40: 416-20, Epub 2011 Sep 28
27. Xue Y, Cai T, Shi S, Wang W, Zhang Y, Mao T*, Duan X*. Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011. Orphanet J Rare Dis, 2011, 6:20，Epub, May 10
28. Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, Cha B, Hubbard A, Donowitz M*, Guggino S. Chloride channel (CLC)-5 is necessary for exocytic trafficking of NHE3. J Biol Chem, 2011 Epub May 11
29. Duan X*, Mao Y, Wen X, Yang T, Xue Y. Excess fluoride interferes with chloride channels dependent endocytosis in ameloblasts. J Dent Res, 2011, 90(2): 175-180
30. Wang H, Mao Y, Zhang B, Wang T, Li F, Fu S, Xue Y, Yang T, Wen X, Ding Y*, Duan X*. Chloride channel ClC-3 promotion of osteogenic differentiation through Runx2. J Cell Biochem, 2010, 111(1): 49-58
31. Wang H, Huo N, Li F, Fu S, Xue Y, Yang T, Wen X, Ding Y*, Duan X*. Osteogenic role of endosomal chloride channels in MC3T3-E1 cells. Mol Cell Biochem, 2010, 342 (1-2): 191-199.
32. Tian M, Duan Y*, Duan X*. Chloride channels regulate chondrogenesis in chicken mandibular mesenchymal cells. Archs Oral Biol, 2010, 55, 938-945
33. Duan X*, Mao Y, Yang T, Wen X, Wang H, Xue Y, Zhang Y. ClC-5 regulates dentin development through TGF-b1 pathway. Archs Oral Biol, 2009, 54: 1118-1124
34. Hou J, Situ Z, Duan X*. ClC chloride channels in tooth germ and odontoblast-like MDPC-23 cells. Archs Oral Biol, 2008, 53: 874-878
35. Duan X*, Mao Y. Dong S, Wang W. Spatial-temporal distribution of CLC-5 in rat tooth germ development. Journal of Dental Research, 2004, 83: Special Issue A: 2741 Abstract
36. Mao Y*, Duan X. Attitude of Chinese orthodontists towards the relationship between orthodontic treatment and temporomandibular disorders. Int Dent J. 2001 Aug;51(4):277-81
37. Duan X*, Wu J, Mao Y, Wang H, Wang M. A Retrospective Study on the Relationship between Aging and Tomographic Findings in 174 Patients with TMD. Oral Radiol, 1999 15(1): 9-17